ENPP3 - ectonucleotide pyrophosphatase/phosphodiesterase 3 Gene

Homo sapiens

Also known as B10; NPP3; PDNP3; CD203c; PD-IBETA

Gene ID: 5169 | Gene type: protein coding

About ENPP3

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:131,637,302-131,747,410 (from NCBI)

This gene has 7 transcripts (splice variants), 146 orthologues and 6 paralogues. Biased expression in small intestine (RPKM 19.6), duodenum (RPKM 6.7) and 6 other tissues.

Summary

The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015]

ENPP3 Products(1)

mRNA	Protein	Name
NM_005021.5	NP_005012.2	ectonucleotide pyrophosphatase/phosphodiesterase family member 3

ENPP3 Protein Structure

Somatomedin_B

Phosphodiest

Endonuclease_NS

0
200
400
600
800
875 a.a.

Protein Preferred Names

Protein Names

ectonucleotide pyrophosphatase/phosphodiesterase family member 3

dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3)

Recombinant ENPP3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77924	ENPP-3 Protein, Human (828a.a, HEK293, His-Avi)	O14638 (L48-I875)	≥95%
HY-P77925	ENPP-3 Protein, Human (Biotinylated, 828a.a, HEK293, His-Avi)	O14638 (L48-I875)	≥95%
HY-P77926	ENPP-3 Protein, Human (110a.a, HEK293, His-Avi)	O14638 (L48-D157)	≥95%
HY-P77927	ENPP-3 Protein, Human (Biotinylated, 110a.a, HEK293, His-Avi)	O14638 (L48-D157)	≥95%
HY-P77928	ENPP-3 Protein, Human (318a.a, HEK293, His)	O14638 (K558-I875)	≥95%
HY-P78884	ENPP-3 Protein, Human (Biotinylated, HEK293, His-Avi)	O14638 (L48-I875)	≥95%
HY-P700410	ENPP3 Protein, Human (HEK293, His)	O14638 (L48-I875)	≥95%

Related Diseases

Diseases

Alias

Amoxicillin Allergy

Beta-Lactam Allergy

Chronic Urticaria

Urticaria Chronic	Chronic Spontaneous Urticaria
Chronic Ordinary Urticaria

Apricot Allergy

Prunus Armeniaca Fruit Allergy

Co-Trimoxazole Allergy

Bactrim Allergy	Cotrimoxazol Allergy
Tmp/Smx Allergy	Trimethoprim/Sulfamethoxazole Allergy

Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria

Cephalosporin Allergy

Crab Allergy

Green Mud Crab Allergy

Scylla Paramamosain Allergy

Chlorhexidine Allergy

Acute Basophilic Leukemia

Ceftazidime Allergy

Fortaz Allergy

Tazicef Allergy

Diclofenac Allergy

Voltaren Allergy

Optic Atrophy 10 With Or Without Ataxia, Mental Retardation, And Seizures

OPA10	Optic Atrophy 10 With Or Without Ataxia, Intellectual Disability, And Seizures
Optic Atrophy 10	Atrophy, Optic, Type 10, With/Without Ataxia, Mental Retardation, And Seizures

Drug Allergy

Allergy Drug

Drug Allergies

Oxirane Allergy

Ethylene Oxide Allergy

Eto Allergy

Physical Urticaria

Symptomatic Dermographism

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Mastocytosis

Mast Cell Disease	Mast Cell Hyperplasia
Urticaria Pigmentosa	Malignant Mastocytoma
Malignant Mast Cell Tumours	Malignant Mastocytosis

Peach Allergy

Prunus Persica Fruit Allergy

Nut Allergy

Nut Allergic Reaction	Nut Hypersensitivity
Allergy To Nuts	Allergy Nut

Dermatographia

Dermatographic Urticaria	Dermographism
Symptomatic Dermographism	Urticaria Factitia
Factitious Urticaria	Dermatographism

Carbapenem Allergy

Cholinergic Urticaria

Pollen Allergy

Hay Fever

Fruit Allergy

Allergy To Fruit

Legume Allergy

Fabaceae Allergy

Egg Allergy

Allergy To Eggs	Allergies Egg
Egg Hypersensitivity

Latex Allergy

Aspergillosis

Aspergillosis, Susceptibility To	Infection Due To Aspergillus
Aspergilloma	Aspergillus Nodule
Simple Aspergilloma	Aspergillus
Aspergillus Flavus Infection	Aspergillus Fumigatus Infection
Aspergillus Infection	Infection By Aspergillus Fumigatus
Intracavitary Aspergillus Fungus Ball	Aspergillus Terreus

Peanut Allergy

Allergy To Peanuts	Peanut Allergic Reaction
Allergies Peanut	Peanut Hypersensitivity

Wheat Allergy

Wheat Allergic Reaction	Wheat Hypersensitivity
Allergy To Wheat	Allergy Wheat

Penicillin Allergy

Allergy To Penicillin

Arterial Calcification Of Infancy

Idiopathic Infantile Arterial Calcification	Generalized Arterial Calcification Of Infancy
Iiac	Occlusive Infantile Arteriopathy
Infantile Arteriosclerosis	Gaci
Idiopathic Obliterative Arteriopathy	Generalized Arterial Calcification In Infancy
Arteriopathia Calcificans Infantum	Diffuse Arterial Calcifying Elastopathy Of Infancy
Infantile Calcifying Arteriopathy	Medial Coronary Sclerosis Of Infancy
Coronary Sclerosis, Medial, Of Infancy	Calcification, Arterial, Generalized, Infancy

Solitary Mastocytoma Of The Skin

Cutaneous Solitary Mastocytoma	Skin Mastocytoma
Solitary Mastocytoma	Solitary Mastocytoma Of Skin
Mastocytoma, Skin

Food Allergy

Food Hypersensitivity	Food Allergies
Allergy Food	Food Allergen-Induced Hypersensitivity

Aggressive Systemic Mastocytosis

Asm	Lymphadenopathic Mastocytosis With Eosinophilia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147998	Enpp-1-IN-13	Inhibitor	/	Unkown
HY-RS04389	ENPP3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ENPP3	VGNC	VGNC:28506
Mus musculus	ENPP3	MGD	MGI:2143702
Canis familiaris	ENPP3	VGNC	VGNC:40376
Macaca mulatta	ENPP3	VGNC	VGNC:72224
Felis catus	ENPP3	VGNC	VGNC:61874
Rattus norvegicus	ENPP3	RGD	RGD:708511
Macaca fascicularis	ENPP3	NCBI
Others	ENPP3	NCBI