Tifa - TRAF-interacting protein with forkhead-associated domain Gene

Also Known as T2bp

Species: Mus musculus

Gene Type: protein coding
Gene ID: 211550

Summary

Acts upstream of or within I-kappaB kinase/NF-kappaB signaling. Predicted to be active in cytoplasm. Is expressed in several structures, including brain ventricular layer; cerebral cortex subventricular zone; gut; liver; and trigeminal ganglion. Orthologous to human TIFA (TRAF interacting protein with forkhead associated domain). [provided by Alliance of Genome Resources, Apr 2022]

Tifa Products (2)

mRNA Protein Name
NM_001356430.1 NP_001343359.1 TRAF-interacting protein with FHA domain-containing protein A
NM_145133.4 NP_660115.1 TRAF-interacting protein with FHA domain-containing protein A

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11798190 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
11798190 MGI
involved in tumor necrosis factor-mediated signaling pathway IPI
IPI: Inferred from physical interaction
11798190 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TRAF-interacting protein with FHA domain-containing protein A

  • Traf2 binding protein

Tifa Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Tifa Q793I8 Traf6 Mus musculus P70196
Y2H
12566447
Intra
Tifa Q793I8 Traf6 Mus musculus P70196
Anti Bait CoIP
12566447
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06736 IL22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14521 TIFA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18262 Tifa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24741 Tifa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tifa NCBI NCBI:92610