Tcap - titin-cap Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21393

Summary

Predicted to enable several functions, including BMP binding activity; cytoskeletal protein binding activity; and titin Z domain binding activity. Predicted to be a structural constituent of muscle. Acts upstream of or within adult heart development; otic vesicle formation; and somitogenesis. Located in Z disc. Is expressed in heart; otocyst; tail somite; and trunk somite. Used to study autosomal recessive limb-girdle muscular dystrophy type 2G. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2G and hypertrophic cardiomyopathy 25. Orthologous to human TCAP (titin-cap). [provided by Alliance of Genome Resources, Apr 2022]

Tcap Products (1)

mRNA Protein Name
NM_011540.2 NP_035670.2 telethonin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11842093 MGI
Biological Process GO Annotation Evidence References Source
involved in adult heart development IEP
IEP: Inferred from expression pattern
9817758 MGI
involved in otic vesicle formation IEP
IEP: Inferred from expression pattern
9817758 MGI
involved in somitogenesis IEP
IEP: Inferred from expression pattern
9817758 MGI
Cellular Component GO Annotation Evidence References Source
located in I band IDA
IDA: Inferred from direct assay
9817758 MGI
located in Z disc IDA
IDA: Inferred from direct assay
9817758 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

telethonin

  • titin cap protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14291 TCAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22341 Tcap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28863 Tcap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tcap NCBI NCBI:8557