Tcf4 - transcription factor 4 Gene

Also Known as ME2; TFE; E2-2; E2.2; ITF2; SEF2; ITF-2; SEF-2; Tcf-4; ASP-I2; ITF-2b; SEF2-1; MITF-2A; MITF-2B; bHLHb19; 5730422P05Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21413

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and TFIIB-class transcription factor binding activity. Involved in positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; and protein-DNA complex assembly. Acts upstream of or within several processes, including negative regulation of angiogenesis; negative regulation of macromolecule metabolic process; and regulation of vascular endothelial growth factor signaling pathway. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study Pitt-Hopkins syndrome and schizophrenia. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and Pitt-Hopkins syndrome. Orthologous to human TCF4 (transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Tcf4 Products (6)

mRNA	Protein	Name
NM_001083967.1	NP_001077436.1	transcription factor 4 isoform b
NM_001361126.1	NP_001348055.1	transcription factor 4 isoform b
NM_001361127.1	NP_001348056.1	transcription factor 4 isoform a
NM_001361128.1	NP_001348057.1	transcription factor 4 isoform c
NM_001361129.1	NP_001348058.1	transcription factor 4 isoform c
NM_013685.2	NP_038713.1	transcription factor 4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14762206	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8978694	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	25620640	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8978694	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	8978694	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8978694	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	25620640	MGI
enables TFIIB-class transcription factor binding	IDA IDA: Inferred from direct assay	8978694	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	24192035	MGI
enables identical protein binding	IMP IMP: Inferred from mutant phenotype	20231428	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8999959	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	18214987	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	8999959	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within endothelial cell activation	IDA IDA: Inferred from direct assay	20231428	MGI
acts upstream of or within negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	20231428	MGI
acts upstream of or within negative regulation of gene expression	IDA IDA: Inferred from direct assay	20231428	MGI
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	18214987	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8978694	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25620640	MGI
involved in protein-DNA complex assembly	IDA IDA: Inferred from direct assay	8978694	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15351717	MGI
acts upstream of or within regulation of vascular endothelial growth factor signaling pathway	IDA IDA: Inferred from direct assay	20231428	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	19796622	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	8978694	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor 4	MITF-2 SL3-3 enhancer factor 2 Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2) class A helix-loop-helix transcription factor ME2 immu

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1360	Chlorquinaldol		98.69%	Unkown

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101486	LF3	Antagonist	99.55%	Unkown
HY-100760	Toxoflavin	Inhibitor	99.88%	Unkown
HY-P10392B	aStAx-35R TFA		99.07%	Unkown
HY-119966	CCT036477	Inhibitor	99.42%	Unkown
HY-122649	UU-T01	Inhibitor	99.88%	Unkown
HY-100760S	Toxoflavin-13C4	Inhibitor	/	Unkown
HY-124826	BC21	Inhibitor	/	Unkown
HY-149858	β-catenin-IN-7	Inhibitor	/	Unkown
HY-157126	Pterostilbene-isothiocyanate	Inhibitor	/	Unkown
HY-172393	TCF4/β-catenin-IN-1		/	Unkown
HY-181560	SLD1121	Agonist	/	Unkown
HY-N3393	Lethedioside A	Inhibitor	/	Unkown
HY-P10392	aStAx-35R		/	Unkown
HY-P11660	β-catenin-IN-10	Inhibitor	/	Unkown
HY-RS14307	TCF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14310	TCF7L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-133093	Murayaquinone	Inhibitor	/	Unkown
HY-RS17416	Tcf4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17858	Tcf7l2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23870	Tcf4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tcf4	NCBI	NCBI:6925