Duox2 - dual oxidase 2 Gene

Also Known as LNOX2; THOX2; NOXEF2; P138-TOX; A430065P05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 214593

Summary

Predicted to enable NAD(P)H oxidase H2O2-forming activity; calcium ion binding activity; and superoxide-generating NAD(P)H oxidase activity. Acts upstream of or within animal organ development; fertilization; and thyroid hormone metabolic process. Predicted to be located in several cellular components, including cell leading edge; cell surface; and endoplasmic reticulum. Predicted to be part of NADPH Oxidase complex. Predicted to be active in plasma membrane. Is expressed in placenta and thyroid gland. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 6. Orthologous to human DUOX2 (dual oxidase 2). [provided by Alliance of Genome Resources, Apr 2022]

Duox2 Products (1)

mRNA Protein Name
NM_001362755.1 NP_001349684.1 dual oxidase 2 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenohypophysis morphogenesis IMP
IMP: Inferred from mutant phenotype
17440044 MGI
acts upstream of or within bone mineralization IMP
IMP: Inferred from mutant phenotype
17440044 MGI
acts upstream of or within fertilization IMP
IMP: Inferred from mutant phenotype
17440044 MGI
acts upstream of or within hormone metabolic process IMP
IMP: Inferred from mutant phenotype
17440044 MGI
acts upstream of or within inner ear development IMP
IMP: Inferred from mutant phenotype
17440044 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
17440044 MGI
acts upstream of or within thyroid gland development IMP
IMP: Inferred from mutant phenotype
17440044 MGI
acts upstream of or within thyroid hormone metabolic process IMP
IMP: Inferred from mutant phenotype
17440044 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual oxidase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04045 DUOX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20913 Duox2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22474 Duox1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27430 Duox2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Duox2 NCBI NCBI:50506