Nags - N-acetylglutamate synthase Gene

Also Known as argA; 1700120E20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 217214

Summary

Enables acetyl-CoA:L-glutamate N-acetyltransferase activity. Acts upstream of or within glutamate metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in N-acetylglutamate synthase deficiency and amino acid metabolic disorder. Orthologous to human NAGS (N-acetylglutamate synthase). [provided by Alliance of Genome Resources, Apr 2022]

Nags Products (1)

mRNA Protein Name
NM_145829.2 NP_665828.1 N-acetylglutamate synthase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables L-glutamate N-acetyltransferase activity IDA
IDA: Inferred from direct assay
12049647 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within glutamate metabolic process IDA
IDA: Inferred from direct assay
12049647 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

N-acetylglutamate synthase, mitochondrial

  • amino-acid N-acetyltransferase

  • amino-acid acetyltransferase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0711 Carglumic Acid Activator 99.90% Yes
HY-B0711R Carglumic Acid (Standard) Activator 99.91% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-132604 Fazirsiran / Phase 3

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103332 N-Arachidonylglycine Inhibitor 99.45% Unkown
HY-139431 NAG-thiazoline Inhibitor ≥95.0% Unkown
HY-132604A Fazirsiran sodium 93.25% Unkown
HY-173247 GalNAc-NAG37 phosphoramidite Ligand 98.0% Unkown
HY-103332S N-Arachidonylglycine-d8 Inhibitor 98.1% Unkown
HY-173248 GalNAc-NAG15 phosphoramidite / Unkown
HY-165504 Nagstatin Inhibitor / Unkown
HY-147112 MNP-GAL / Unkown
HY-173246 GalNAc-NAG25 phosphoramidite / Unkown
HY-178978 α,δ-NAG Activator / Unkown
HY-180637 N-Acetyl-L-glutamate 5-phosphate / Unkown
HY-E70184 α-N-Acetylglucosaminidase / Unkown
HY-RS09013 NAGS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19356 Nags Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25847 Nags Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nags NCBI NCBI:162417