2. Gene
  3. Tyms - thymidylate synthase Gene

Tyms - thymidylate synthase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ts

Gene ID: 22171 | Gene type: protein coding

About Tyms

Chromosome 5: 30,263,200-30,278,615 reverse strand.GRCm39:CM000998.3

This gene has 9 transcripts (splice variants), 225 orthologues and 1 paralogue. Broad expression in liver E14 (RPKM 1.5), liver E14.5 (RPKM 8.8) and 23 other tissues.

Summary

This gene encodes an Enzyme that catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate as a cofactor. This function maintains the thymidine-5-prime monophosphate concentration critical for DNA replication and repair. The encoded Enzyme is a target for Cancer chemotherapeutic agents. The majority of transcripts for this gene lack a 3' UTR (PMID: 3022294, 3444407). The stop codon in these transcripts is UAA, compared to the UAG found in the genome and longer transcripts, as the polyA site is located within the stop codon (PMID: 3444407, 2157203). A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Mar 2010]

Tyms Products(1)

mRNA Protein Name
NM_021288.4 NP_067263.1 thymidylate synthase

Tyms Protein Structure

PTZ00164

PTZ00164: cl36520 (21 - 306)

  • 0
  • 100
  • 200
  • 307 a.a.
Protein Preferred Names Protein Names

thymidylate synthase

Tsase

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-163538 TYM-3-98 / Unkown
HY-RS15304 TYMS Human Pre-designed siRNA Set A / Unkown
HY-RS15305 Tyms Mouse Pre-designed siRNA Set A / Unkown
HY-RS15306 Tyms Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tyms NCBI NCBI:7298