Tyms - thymidylate synthase Gene

Also Known as Ts

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22171

About Tyms

Chromosome 5: 30,263,200-30,278,615 reverse strand.GRCm39:CM000998.3

This gene has 9 transcripts (splice variants), 225 orthologues and 1 paralogue. Broad expression in liver E14 (RPKM 1.5), liver E14.5 (RPKM 8.8) and 23 other tissues.

Summary

This gene encodes an enzyme that catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate as a cofactor. This function maintains the thymidine-5-prime monophosphate concentration critical for DNA replication and repair. The encoded enzyme is a target for Cancer chemotherapeutic agents. The majority of transcripts for this gene lack a 3' UTR (PMID: 3022294, 3444407). The stop codon in these transcripts is UAA, compared to the UAG found in the genome and longer transcripts, as the polyA site is located within the stop codon (PMID: 3444407, 2157203). A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Mar 2010]

Tyms Products (1)

mRNA Protein Name
NM_021288.4 NP_067263.1 thymidylate synthase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables thymidylate synthase activity IDA
IDA: Inferred from direct assay
22057276 MGI
Biological Process GO Annotation Evidence References Source
involved in dTMP biosynthetic process IDA
IDA: Inferred from direct assay
22057276 MGI
involved in tetrahydrofolate interconversion IDA
IDA: Inferred from direct assay
22057276 MGI
Cellular Component GO Annotation Evidence References Source
is active in nucleus IDA
IDA: Inferred from direct assay
19513116 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tyms Protein Structure

PTZ00164

PTZ00164: cl36520 (21 - 306)

  • 0
  • 100
  • 200
  • 307 a.a.
Protein Preferred Names Protein Names

thymidylate synthase

  • Tsase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163538 TYM-3-98 99.56% Unkown
HY-RS15304 TYMS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15305 Tyms Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15306 Tyms Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N3764 Diosbulbin C Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tyms NCBI NCBI:7298