Usp5 - ubiquitin specific peptidase 5 (isopeptidase T) Gene

Also Known as ISOT; Ucht; ISOT-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22225

Summary

Predicted to enable cysteine-type endopeptidase activity; thiol-dependent deubiquitinase; and ubiquitin binding activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein K48-linked deubiquitination. Predicted to act upstream of or within proteolysis. Predicted to be active in cytosol and nucleus. Orthologous to human USP5 (ubiquitin specific peptidase 5). [provided by Alliance of Genome Resources, Apr 2022]

Usp5 Products (9)

mRNA Protein Name
NM_001326594.2 NP_001313523.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 2
NM_001410487.1 NP_001397416.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 3
NM_001410488.1 NP_001397417.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 4
NM_001410489.1 NP_001397418.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 5
NM_001410490.1 NP_001397419.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 5
NM_001410491.1 NP_001397420.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 6
NM_001410492.1 NP_001397421.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 6
NM_001410493.1 NP_001397422.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 6
NM_013700.3 NP_038728.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19156909 MGI
Biological Process GO Annotation Evidence References Source
involved in regulation protein catabolic process at presynapse EXP
EXP: Inferred from Experiment
25189210 MGI
involved in regulation protein catabolic process at presynapse IDA
IDA: Inferred from direct assay
25189210 MGI
involved in regulation protein catabolic process at presynapse IEP
IEP: Inferred from expression pattern
25189210 MGI
involved in regulation protein catabolic process at presynapse IMP
IMP: Inferred from mutant phenotype
25189210 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 5

  • deubiquitinating enzyme 5

  • isopeptidase T

  • ubiquitin carboxy terminal hydrolase T

  • ubiquitin specific protease 5

  • ubiquitin thioesterase 5

  • ubiquitin thiolesterase 5

  • ubiquitin-specific-processing protease 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13814 PR-619 99.38% Unkown
HY-13264 Degrasyn 99.70% Unkown
HY-139979 USP5-IN-1 Inhibitor 99.73% Unkown
HY-122243 IU1-47 Inhibitor 99.68% Unkown
HY-111408 EOAI3402143 Inhibitor 98.11% Unkown
HY-134817 USP7-IN-8 Inhibitor 99.04% Unkown
HY-103435 Vialinin A 99.90% Unkown
HY-178500A WCY-8-67 TFA 99.40% Unkown
HY-178500 WCY-8-67 / Unkown
HY-172193 UBD1031 Antagonist / Unkown
HY-RS15561 USP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W027296 UBTR008295a Ligand / Unkown
HY-RS16553 Usp5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22986 Usp5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Usp5 NCBI NCBI:8078