Nr1h2 - nuclear receptor subfamily 1, group H, member 2 Gene

Also Known as UR; LXR; Unr; LXRB; NER1; OR-1; Unr2; RIP15; LXRBSV; LXRbeta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22260

Summary

Enables DNA binding activity; nuclear receptor activity; and retinoid X receptor binding activity. Involved in several processes, including Cholesterol homeostasis; positive regulation of transport; and regulation of transcription by RNA polymerase II. Acts upstream of or within cellular lipid metabolic process and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR1H2 (nuclear receptor subfamily 1 group H member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr1h2 Products (4)

mRNA Protein Name
NM_001285517.1 NP_001272446.1 oxysterols receptor LXR-beta isoform a
NM_001285518.1 NP_001272447.1 oxysterols receptor LXR-beta isoform b
NM_001285519.1 NP_001272448.1 oxysterols receptor LXR-beta isoform b
NM_009473.3 NP_033499.1 oxysterols receptor LXR-beta isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
14739254 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14739254 MGI
enables DNA-binding transcription factor activity IGI
IGI: Inferred from genetic interaction
7760852 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
29431742 MGI
enables nuclear receptor activity IDA
IDA: Inferred from direct assay
14739254 MGI
enables nuclear retinoid X receptor binding IDA
IDA: Inferred from direct assay
7760852 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17936707 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular lipid metabolic process IDA
IDA: Inferred from direct assay
14739254 MGI
involved in cholesterol homeostasis IDA
IDA: Inferred from direct assay
17657314 MGI
involved in cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
18055760 MGI
involved in lipid homeostasis IMP
IMP: Inferred from mutant phenotype
18806227 MGI
involved in negative regulation of cold-induced thermogenesis IGI
IGI: Inferred from genetic interaction
21173252 MGI
involved in negative regulation of proteolysis IMP
IMP: Inferred from mutant phenotype
18806227 MGI
involved in negative regulation of response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
24206663 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20388921 MGI
involved in phosphatidylcholine acyl-chain remodeling IMP
IMP: Inferred from mutant phenotype
24206663 MGI
involved in positive regulation of cholesterol efflux IDA
IDA: Inferred from direct assay
16825483 MGI
acts upstream of or within positive regulation of cholesterol efflux IGI
IGI: Inferred from genetic interaction
23931754 MGI
involved in positive regulation of high-density lipoprotein particle assembly IDA
IDA: Inferred from direct assay
16825483 MGI
involved in positive regulation of lipid storage IMP
IMP: Inferred from mutant phenotype
18806227 MGI
acts upstream of positive regulation of miRNA transcription IDA
IDA: Inferred from direct assay
31501273 MGI
involved in positive regulation of pancreatic juice secretion IMP
IMP: Inferred from mutant phenotype
18806227 MGI
involved in positive regulation of secretion of lysosomal enzymes IMP
IMP: Inferred from mutant phenotype
18806227 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16141411 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14739254 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
7760852 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
18806227 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

oxysterols receptor LXR-beta

  • LXR beta

  • liver X receptor beta

  • retinoid X receptor-interacting protein No.15

  • ubiquitously-expressed nuclear receptor 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09529 NR1H2 Human Pre-designed siRNA Set A / Unkown
HY-RS19726 Nr1h2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26222 Nr1h2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr1h2 NCBI NCBI:7376