Vav2 - vav 2 oncogene Gene

Also Known as Vav-2; 2810040F13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22325

Summary

This gene encodes a member of the Vav family of Rho guanine nucleotide exchange factors. Vav family proteins are involved in the development and activation of lymphocytes, and the encoded protein may also be involved in angiogenesis. Disruption of this gene in mice is associated with heart, artery, and kidney defects, as well as tachycardia and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Vav2 Products (1)

mRNA Protein Name
NM_009500.2 NP_033526.1 guanine nucleotide exchange factor VAV2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables epidermal growth factor receptor binding IPI
IPI: Inferred from physical interaction
15728722 MGI
enables guanyl-nucleotide exchange factor activity IMP
IMP: Inferred from mutant phenotype
15728722 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16782872 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell migration IGI
IGI: Inferred from genetic interaction
15728722 MGI
acts upstream of or within cell projection assembly IGI
IGI: Inferred from genetic interaction
15728722 MGI
acts upstream of or within lamellipodium assembly IGI
IGI: Inferred from genetic interaction
15728722 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
15728722 MGI
acts upstream of or within small GTPase-mediated signal transduction IMP
IMP: Inferred from mutant phenotype
15728722 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15728722 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15728722 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanine nucleotide exchange factor VAV2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12810 EHop-016 Inhibitor 99.38% Unkown
HY-RS15613 VAV2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22354 Vav2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28876 Vav2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vav2 NCBI NCBI:7410