Atf6 - activating transcription factor 6 Gene

Also Known as ESTM49; Atf6alpha; 9630036G24; 9130025P16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 226641

About Atf6

Chromosome 1: 170,532,243-170,695,340 reverse strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 218 orthologues, 9 paralogues and is associated with 7 phenotypes. Ubiquitous expression in heart adult (RPKM 1.2), genital fat pad adult (RPKM 8.5) and 28 other tissues.

Summary

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; protein heterodimerization activity; and ubiquitin protein Ligase binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; eye; liver; long bone; and tooth. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Atf6 Products (1)

mRNA Protein Name
NM_001081304.1 NP_001074773.1 cyclic AMP-dependent transcription factor ATF-6 alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19543265 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19615339 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22682248 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Atf6 Protein Structure

bZIP_ATF6

bZIP_ATF6: cd14700 (295 - 346)

  • 0
  • 200
  • 400
  • 600
  • 656 a.a.
Protein Preferred Names Protein Names

cyclic AMP-dependent transcription factor ATF-6 alpha

  • ATF6-alpha

  • activating transcription factor 6 alpha

  • cAMP-dependent transcription factor ATF-6 alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108434 Ceapin-A7 99.95% Unkown
HY-124293 AA147 Activator 99.81% Unkown
HY-W050044 L-Azetidine-2-carboxylic acid 99.97% Unkown
HY-101484A NE-100 hydrochloride Activator 99.1% Unkown
HY-132182 HPA-12 Activator 99.40% Unkown
HY-123581 Quinocetone Activator 98.25% Unkown
HY-158104 LPPM-8 Inhibitor / Unkown
HY-123581R Quinocetone (Standard) Activator 97.94% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atf6 NCBI NCBI:22926