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Ceapin-A7 

Cat. No.: HY-108434
Handling Instructions

Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC50 of 0.59 μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings.

For research use only. We do not sell to patients.

Ceapin-A7 Chemical Structure

Ceapin-A7 Chemical Structure

CAS No. : 2323027-38-7

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Description

Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC50 of 0.59 μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings[1].

IC50 & Target

0.59 μM (ATF6α)[1]

In Vitro

Ceapin-A7 sensitizes cells to ER stress[1].
Ceapin (0.6-18.9 μM; 4.5 hours) selectively inhibits ATF6α but not ATF6β[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

470.32

Formula

C₂₀H₁₂F₆N₄O₃

CAS No.

2323027-38-7

SMILES

O=C(NC1=CN(CC2=CC=C(C(F)(F)F)C=C2C(F)(F)F)N=C1)C3=NOC(C4=CC=CO4)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Ceapin-A7OthersATF6-alphaERtoGolgitraffickingendoplasmicreticulumunfolded protein responseUPRstressInhibitorinhibitorinhibit

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Ceapin-A7
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HY-108434
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