MRAS - muscle RAS oncogene homolog Gene
Also Known as NS11; M-RAs; RRAS3; R-RAS3
Species: Homo sapiens
About MRAS
This gene has 11 transcripts (splice variants), 241 orthologues, 35 paralogues and is associated with 3 phenotypes. Broad expression in fat (RPKM 37.4), heart (RPKM 23.2) and 16 other tissues.
Summary
This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of Cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
MRAS Products (6)
| mRNA | Protein | Name |
|---|---|---|
| NM_001085049.3 | NP_001078518.1 | ras-related protein M-Ras isoform 1 precursor |
| NM_001252090.2 | NP_001239019.1 | ras-related protein M-Ras isoform 1 precursor |
| NM_001252091.1 | NP_001239020.1 | ras-related protein M-Ras isoform 2 precursor |
| NM_001252092.2 | NP_001239021.1 | ras-related protein M-Ras isoform 2 precursor |
| NM_001252093.2 | NP_001239022.1 | ras-related protein M-Ras isoform 2 precursor |
| NM_012219.4 | NP_036351.3 | ras-related protein M-Ras isoform 1 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables GTP-dependent protein binding |
IPI
IPI: Inferred from physical interaction
|
10934204 | GOA |
| enables GTPase activity |
IMP
IMP: Inferred from mutant phenotype
|
28289718 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
25137548 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in Ras protein signal transduction |
IMP
IMP: Inferred from mutant phenotype
|
28289718 | GOA |
MRAS Protein Structure
Ras: Ras family (15 - 176)
- 0
- 100
- 208 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
ras-related protein M-Ras |
|
MRAS Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83335 | MRAS Antibody (YA3080) | WB, IP | Human, Mouse, Rat |
| HY-P83335A | MRAS Antibody (YA3080)(PBS only) | WB, IP | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Noonan Syndrome 11 |
|
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| Noonan Syndrome 1 |
|
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| Rasopathy |
|
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| Hypertrophic Cardiomyopathy |
|
|
| Juvenile Myelomonocytic Leukemia |
|
|
| Noonan Syndrome With Multiple Lentigines |
|
|
| Neurofibromatosis-Noonan Syndrome |
|
|
| Cardiofaciocutaneous Syndrome 1 |
|
|
| Costello Syndrome |
|
|
| Neurilemmomatosis |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MRAS | RGD | RGD:3111 |
| Macaca mulatta | MRAS | VGNC | VGNC:74924 |
| Bos taurus | MRAS | VGNC | VGNC:31597 |
| Felis catus | MRAS | VGNC | VGNC:68314 |
| Canis familiaris | MRAS | VGNC | VGNC:43358 |
| Mus musculus | MRAS | MGD | MGI:1100856 |
| Others | MRAS | NCBI |