MRAS - muscle RAS oncogene homolog Gene

Also Known as NS11; M-RAs; RRAS3; R-RAS3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22808

About MRAS

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:138,347,648-138,405,535 (from NCBI)

This gene has 11 transcripts (splice variants), 241 orthologues, 35 paralogues and is associated with 3 phenotypes. Broad expression in fat (RPKM 37.4), heart (RPKM 23.2) and 16 other tissues.

Summary

This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of Cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

MRAS Products (6)

mRNA Protein Name
NM_001085049.3 NP_001078518.1 ras-related protein M-Ras isoform 1 precursor
NM_001252090.2 NP_001239019.1 ras-related protein M-Ras isoform 1 precursor
NM_001252091.1 NP_001239020.1 ras-related protein M-Ras isoform 2 precursor
NM_001252092.2 NP_001239021.1 ras-related protein M-Ras isoform 2 precursor
NM_001252093.2 NP_001239022.1 ras-related protein M-Ras isoform 2 precursor
NM_012219.4 NP_036351.3 ras-related protein M-Ras isoform 1 precursor
Molecular Function GO Annotation Evidence References Source
enables GTP-dependent protein binding IPI
IPI: Inferred from physical interaction
10934204 GOA
enables GTPase activity IMP
IMP: Inferred from mutant phenotype
28289718 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25137548 GOA
Biological Process GO Annotation Evidence References Source
involved in Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
28289718 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRAS Protein Structure

Ras

Ras: Ras family (15 - 176)

  • 0
  • 100
  • 208 a.a.
Protein Preferred Names Protein Names

ras-related protein M-Ras

  • muscle and microspikes RAS

MRAS Antibodies

Cat. No. Product Name Application Reactivity
HY-P83335 MRAS Antibody (YA3080) WB, IP Human, Mouse, Rat
HY-P83335A MRAS Antibody (YA3080)(PBS only) WB, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Noonan Syndrome 11
  • NS11

Noonan Syndrome 1
  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male

Rasopathy
  • Ras/Mitogen-Activated Protein Kinase Syndrome

Hypertrophic Cardiomyopathy
  • Hypertrophic Obstructive Cardiomyopathy

  • Cardiomyopathy, Hypertrophic

  • Cardiomyopathy Hypertrophic Obstructive

  • Cardiomyopathy, Hypertrophic, Familial

  • Idiopathic Myocardial Hypertrophy

  • Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Cardiomyopathy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Muscular Subaortic Stenosis

  • Hypertrophic Obstructive Subaortic Stenosis

Juvenile Myelomonocytic Leukemia
  • Leukemia, Juvenile Myelomonocytic

  • JMML

  • Leukemia, Juvenile Myelomonocytic, Somatic

  • Juvenile Chronic Myelomonocytic Leukemia

  • Juvenile Chronic Myelogenous Leukemia

  • Leukemia, Myelomonocytic, Juvenile

  • Juvenile Myelomonocytic Leukaemia Without Mention Of Remission

Noonan Syndrome With Multiple Lentigines
  • Leopard Syndrome

  • Multiple Lentigines Syndrome

  • Moynahan Syndrome

  • Cardiomyopathic Lentiginosis

  • Progressive Cardiomyopathic Lentiginosis

  • Cardio-Cutaneous Syndrome

  • Lentiginosis Profusa

  • Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome

  • Generalized Lentiginosis

  • Gorlin Syndrome Ii

  • Lentiginosis Profusa Syndrome

  • Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes

  • Diffuse Lentiginosis

  • Nsml

  • Familial Multiple Lentigines Syndrome

  • Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type

  • Progressive Cardiomyopathic Lentiginosis Syndrome

  • Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan

Neurofibromatosis-Noonan Syndrome
  • NFNS

  • Neurofibromatosis Type 1

  • Neurofibromatosis With Noonan Phenotype

  • Nf1

  • Von Recklinghausen Disease

  • Neurofibromatosis Type 1-Noonan Syndrome

  • Noonan Neurofibromatosis Syndrome

  • Recklinghausen'S Disease

  • Noonan-Neurofibromatosis Syndrome

  • Fibromatosis Multiple Non Ossifying

  • Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots

  • Jaffe Campanacci Syndrome

  • Type 1 Neurofibromatosis

  • Neurofibromatosis 1

  • Peripheral Neurofibromatosis

  • Recklinghausen Disease, Nerve

  • Jaffe-Campanacci Syndrome

Cardiofaciocutaneous Syndrome 1
  • Cardiofaciocutaneous Syndrome

  • Cfc Syndrome

  • Cardio-Facio-Cutaneous Syndrome

  • CFC1

  • Cfcs

  • Cardio-Facial-Cutaneous Syndrome

  • Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure

  • Cardiofaciocutaneous Syndrome, Type 1

Costello Syndrome
  • Faciocutaneoskeletal Syndrome

  • Fcs Syndrome

  • Congenital Myopathy With Excess Of Muscle Spindles

  • CSTLO

  • CMEMS

  • Fcss

  • Myopathy, Congenital, With Excess Of Muscle Spindles

Neurilemmomatosis
  • Schwannomatosis

  • Neurofibromatosis Type 3

  • Nf3

  • Neurilemmomatosis Congenital Cutaneous

  • Neurinomatosis

  • Congenital Cutaneous Neurilemmomatosis

  • Multiple Neurilemmomas

  • Multiple Schwannomas

  • Neurilemmomatosis, Congenital Cutaneous

  • Schwannomatosis 1

  • Neurofibromatosis 3

  • Mixed Central And Peripheral Neurofibromatosis

  • Nf3 - [Neurofibromatosis Type 3]

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MRAS RGD RGD:3111
Macaca mulatta MRAS VGNC VGNC:74924
Bos taurus MRAS VGNC VGNC:31597
Felis catus MRAS VGNC VGNC:68314
Canis familiaris MRAS VGNC VGNC:43358
Mus musculus MRAS MGD MGI:1100856
Others MRAS NCBI