Trib3 - tribbles pseudokinase 3 Gene

Also Known as Nipk; SINK; Trb3; Ifld2; SKIP3; TRB-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 228775

Summary

Enables enzyme binding activity; transcription corepressor activity; and ubiquitin-protein transferase regulator activity. Involved in several processes, including negative regulation of fat cell differentiation; negative regulation of fatty acid biosynthetic process; and regulation of protein modification process. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart; and retina. Orthologous to human TRIB3 (tribbles pseudokinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Trib3 Products (1)

mRNA Protein Name
NM_175093.2 NP_780302.2 tribbles homolog 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
16794074 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12749859 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
12791994 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
12749859 MGI
enables ubiquitin protein ligase binding IDA
IDA: Inferred from direct assay
20410507 MGI
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
16794074 MGI
enables ubiquitin-protein transferase regulator activity IDA
IDA: Inferred from direct assay
20410507 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
12791994 MGI
involved in negative regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
17576771 MGI
involved in negative regulation of fatty acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
16794074 MGI
involved in negative regulation of protein kinase activity IDA
IDA: Inferred from direct assay
12791994 MGI
involved in positive regulation of protein binding IDA
IDA: Inferred from direct assay
16794074 MGI
involved in positive regulation of ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
16794074 MGI
involved in regulation of D-glucose transmembrane transport IDA
IDA: Inferred from direct assay
12791994 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12749859 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tribbles homolog 3

  • induced in fatty liver dystrophy 2

  • neuronal cell death-inducible putative kinase

Trib3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Trib3 Q8K4K2 Akt1 Mus musculus P31750
Y2H
12791994
Intra
Trib3 Q8K4K2 Akt1 Mus musculus P31750
Anti Tag CoIP
12791994
Intra
Trib3 Q8K4K2 Akt1 Mus musculus P31750
Pull Down
12791994
Intra
Trib3 Q8K4K2 Atf4 Mus musculus Q06507
Anti Tag CoIP
12749859
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16261 Trib3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15017 TRIB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23486 Trib3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trib3 NCBI NCBI:57761