TRIB3 - tribbles pseudokinase 3 Gene

Homo sapiens

Also known as NIPK; SINK; TRB3; SKIP3; C20orf97

Gene ID: 57761 | Gene type: protein coding

About TRIB3

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:380,760-397,559 (from NCBI)

This gene has 4 transcripts (splice variants), 192 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 19.9), liver (RPKM 5.0) and 16 other tissues.

Summary

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced Apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase Akt1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]

TRIB3 Products(6)

mRNA	Protein	Name
NM_001301188.1	NP_001288117.1	tribbles homolog 3 isoform 1
NM_001301190.1	NP_001288119.1	tribbles homolog 3 isoform 1
NM_001301193.1	NP_001288122.1	tribbles homolog 3 isoform 1
NM_001301196.1	NP_001288125.1	tribbles homolog 3 isoform 1
NM_001301201.1	NP_001288130.1	tribbles homolog 3 isoform 2
NM_021158.5	NP_066981.2	tribbles homolog 3 isoform 1

TRIB3 Protein Structure

Pkinase

0
100
200
300
358 a.a.

Protein Preferred Names

Protein Names

tribbles homolog 3

TRB-3

Recombinant TRIB3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74491	TRIB3 Protein, Human (sf9, GST)	Q96RU7 (M1-G358)	≥95%

Related Diseases

Diseases

Alias

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Geotrichosis

Diabetes Mellitus

Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15017	TRIB3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRIB3	VGNC	VGNC:81253
Rattus norvegicus	TRIB3	RGD	RGD:708432
Canis familiaris	TRIB3	VGNC	VGNC:47802
Bos taurus	TRIB3	VGNC	VGNC:36310
Mus musculus	TRIB3	MGD	MGI:1345675
Macaca mulatta	TRIB3	VGNC	VGNC:79015
Others	TRIB3	NCBI

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