TRIB3 - tribbles pseudokinase 3 Gene

Also Known as NIPK; SINK; TRB3; SKIP3; C20orf97

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57761

About TRIB3

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:380,760-397,559 (from NCBI)

This gene has 4 transcripts (splice variants), 192 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 19.9), liver (RPKM 5.0) and 16 other tissues.

Summary

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced Apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase Akt1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]

TRIB3 Products (6)

mRNA Protein Name
NM_001301188.1 NP_001288117.1 tribbles homolog 3 isoform 1
NM_001301190.1 NP_001288119.1 tribbles homolog 3 isoform 1
NM_001301193.1 NP_001288122.1 tribbles homolog 3 isoform 1
NM_001301196.1 NP_001288125.1 tribbles homolog 3 isoform 1
NM_001301201.1 NP_001288130.1 tribbles homolog 3 isoform 2
NM_021158.5 NP_066981.2 tribbles homolog 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
NOT enables kinase activity IDA
IDA: Inferred from direct assay
12743605 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12743605 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
12791994 GOA
Biological Process GO Annotation Evidence References Source
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
15775988 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
15775988 GOA
involved in negative regulation of protein kinase activity IDA
IDA: Inferred from direct assay
12791994 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15775988 GOA
involved in regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
15299019 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
15775988 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIB3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (111 - 315)

  • 0
  • 100
  • 200
  • 300
  • 358 a.a.
Protein Preferred Names Protein Names

tribbles homolog 3

  • TRB-3

TRIB3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRIB3 Q96RU7 PADI4 Homo sapiens Q9UM07
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 APOBEC3C Homo sapiens Q9NRW3
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 RPGRIP1 Homo sapiens Q96KN7
Validated Y2H
25416956
Intra
TRIB3 Q96RU7 RPGRIP1 Homo sapiens Q96KN7-4
Validated Y2H
25910212
Intra
TRIB3 Q96RU7 RPGRIP1 Homo sapiens Q96KN7-4
Y2H Bait-Prey Pool
25910212
Intra
TRIB3 Q96RU7 RPGRIP1 Homo sapiens Q96KN7-4
Y2H Array
25910212
Intra
TRIB3 Q96RU7 SHFL Homo sapiens Q9NUL5-4
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 SPAG8 Homo sapiens Q99932-2
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 GPATCH2L Homo sapiens Q9NWQ4-1
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 PITX2 Homo sapiens Q99697-2
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 PKNOX2 Homo sapiens Q96KN3
Y2H Prey Pooling
32296183
Intra
TRIB3 Q96RU7 PKNOX2 Homo sapiens Q96KN3
Y2H Array
32296183
Intra
TRIB3 Q96RU7 PARD6B Homo sapiens Q9BYG5
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 PRMT5 Homo sapiens O14744
Y2H
23455924
Intra
TRIB3 Q96RU7 PRMT5 Homo sapiens O14744
Anti Tag CoIP
23455924
Intra
TRIB3 Q96RU7 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra
TRIB3 Q96RU7 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra
TRIB3 Q96RU7 EXOSC5 Homo sapiens Q9NQT4
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 ATF4 Homo sapiens P18848
Y2H Array
25416956
Intra
TRIB3 Q96RU7 ATF4 Homo sapiens P18848
Y2H Array
32296183
Intra
TRIB3 Q96RU7 ATF4 Homo sapiens P18848
Y2H Prey Pooling
25416956
Intra
TRIB3 Q96RU7 ATF4 Homo sapiens P18848
Y2H Prey Pooling
32296183
Intra
TRIB3 Q96RU7 ATF4 Homo sapiens P18848
Validated Y2H
25910212
Intra
TRIB3 Q96RU7 ATF4 Homo sapiens P18848
Y2H
12743605
Intra
TRIB3 Q96RU7 ATF4 Homo sapiens P18848
Y2H Bait-Prey Pool
25910212
Intra
TRIB3 Q96RU7 ATF4 Homo sapiens P18848
Y2H Array
25910212
Intra
TRIB3 Q96RU7 ATF4 Homo sapiens P18848
Validated Y2H
25416956
Intra
TRIB3 Q96RU7 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
TRIB3 Q96RU7 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
TRIB3 Q96RU7 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
TRIB3 Q96RU7 UTP23 Homo sapiens Q9BRU9
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 INO80B Homo sapiens Q9C086
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 MDFI Homo sapiens Q99750
Y2H Bait-Prey Pool
25910212
Intra
TRIB3 Q96RU7 MDFI Homo sapiens Q99750
Validated Y2H
25910212
Intra
TRIB3 Q96RU7 MDFI Homo sapiens Q99750
Y2H Array
25910212
Intra
TRIB3 Q96RU7 TCF19 Homo sapiens Q9Y242
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 ARMC7 Homo sapiens Q9H6L4
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra
TRIB3 Q96RU7 TEKT3 Homo sapiens Q9BXF9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TRIB3 Proteins

Cat. No. Product Name Accession Purity
HY-P74491 TRIB3 Protein, Human (sf9, GST) Q96RU7 (M1-G358) ≥ 90%, as determined by reducing SDS-PAGE.

TRIB3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82429 TRIB3 Antibody (YA2174) WB Human

Related Diseases

Diseases Alias
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Geotrichosis
Diabetes Mellitus

  • Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16261 Trib3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15017 TRIB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23486 Trib3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TRIB3 VGNC VGNC:81253
Rattus norvegicus TRIB3 RGD RGD:708432
Canis familiaris TRIB3 VGNC VGNC:47802
Bos taurus TRIB3 VGNC VGNC:36310
Mus musculus TRIB3 MGD MGI:1345675
Macaca mulatta TRIB3 VGNC VGNC:79015
Others TRIB3 NCBI