SCAP - SREBF chaperone Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22937

About SCAP

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:47,413,681-47,477,127 (from NCBI)

This gene has 14 transcripts (splice variants), 201 orthologues and 10 paralogues. Ubiquitous expression in adrenal (RPKM 22.6), testis (RPKM 19.9) and 25 other tissues.

Summary

This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of Cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

SCAP Products (2)

mRNA	Protein	Name
NM_001320044.2	NP_001306973.1	sterol regulatory element-binding protein cleavage-activating protein isoform 2
NM_012235.4	NP_036367.2	sterol regulatory element-binding protein cleavage-activating protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17428920	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in SREBP signaling pathway	IDA IDA: Inferred from direct assay	32322062	GOA
involved in SREBP signaling pathway	IMP IMP: Inferred from mutant phenotype	11726962	GOA
involved in positive regulation of cholesterol biosynthetic process	IDA IDA: Inferred from direct assay	32322062	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	32111832	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	32111832	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCAP Protein Structure

Sterol-sensing

WD40

0
200
400
600
800
1000
1200
1279 a.a.

Protein Preferred Names	Protein Names
sterol regulatory element-binding protein cleavage-activating protein	SREBP cleavage-activating protein

Related Diseases

Diseases	Alias
Malt Worker'S Lung	Alveolitis Due To Aspergillus Clavatus Malt Worker Lung Malt Workers' Lung Malt-Workers' Lung Malt Fever Malt House Workers' Cough Malt-Workers' Alveolitis Malt-Workers' Lung Disease Alveolitis Due To Aspergillus Fumigatus Extrinsic Allergic Alveolitis Due To Aspergillus Spp
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Hypercholesterolemia, Familial, 1	Hypercholesterolemia FHCL1 Fhc Fh Hyperlipoproteinemia, Type Ii Hyperlipoproteinemia, Type Iia Hyper-Low-Density-Lipoproteinemia Hypercholesterolemic Xanthomatosis, Familial Ldl Receptor Disorder Hypercholesterolemia, Susceptibility To Hypercholesterolemia, Familial, Modifier Of Hypercholesterolemia, Familial, Due To Ldlr Defect, Modifier Of Ldl Cholesterol Level Qtl2 Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial, Type 1 High Cholesterol Increased Cholesterol Low-Density-Lipoid-Type Hyperlipoproteinemia Pure Hypercholesterolaemia Ldl - [Low Density Lipoprotein} Hyperlipoproteinemia Group A Hyperlipidaemia Pure Hypercholesterinaemia Cholesterolaemia Essential Cholesterolaemia Essential Hypercholesterolaemia Group A Hyperlipemia Increased Low Density Lipoprotein Low-Density-Lipoprotein-Type Low-Density-Lipoprotein-Type Hyperlipoproteinemia
Smith-Lemli-Opitz Syndrome	SLOS Rsh Syndrome 7-Dehydrocholesterol Reductase Deficiency Slo Syndrome Rutledge Lethal Multiple Congenital Anomaly Syndrome Lethal Acrodysgenital Syndrome Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobar Lung Smith-Opitz-Inborn Syndrome Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobular Lung Smith Lemli Opitz Syndrome Smith-Lemli-Opitz Syndrome, Type Ii
Niemann-Pick Disease, Type C1	Niemann-Pick Disease, Type C NPC1 Niemann-Pick Disease, Type D Niemann-Pick Disease Type C1 Niemann-Pick Disease With Cholesterol Esterification Block Niemann-Pick Disease, Subacute Juvenile Form Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia Npc Niemann-Pick Disease, Chronic Neuronopathic Form Niemann-Pick Disease Without Sphingomyelinase Deficiency Niemann-Pick Disease Type C Niemann-Pick Disease Type D Niemann-Pick C1 Disease Niemann-Pick Disease C1 Niemann-Pick Disease Chronic Neuronopathic Form Niemann-Pick Disease Nova Scotian Type Niemann-Pick Disease Subacute Juvenile Form Niemann-Pick Disease Type Ii Niemann-Picks Disease Type C
Niemann-Pick Disease	Sphingomyelin/Cholesterol Lipidosis Niemann-Pick Diseases Lipoid Histiocytosis Sphingomyelin Lipidosis Sphingomyelinase Deficiency Disease Lipid Histiocytosis Neuronal Cholesterol Lipidosis Neuronal Lipidosis Npd Sphingomyelinase Deficiency Niemann-Pick Disease, Type A

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14452	Fatostatin	Inhibitor	99.85%	Unkown
HY-N0288	Lycorine		99.98%	Unkown
HY-14452A	Fatostatin hydrobromide	Inhibitor	99.52%	Unkown
HY-N0288R	Lycorine (Standard)		99.54%	Unkown
HY-16244	GW-300	Ligand	/	Unkown
HY-RS12484	SCAP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12823	SH2D2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-149657	SREBP/SCAP-IN-1	Inhibitor	/	Unkown
HY-149658	SREBP/SCAP-IN-2	Inhibitor	/	Unkown
HY-RS17143	Scap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23590	Scap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W129441	N-Acetyl-4-S-cysteaminylphenol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SCAP	VGNC	VGNC:34320
Canis familiaris	SCAP	VGNC	VGNC:45894
Felis catus	SCAP	VGNC	VGNC:64898
Rattus norvegicus	SCAP	RGD	RGD:1309378
Mus musculus	SCAP	MGD	MGI:2135958
Macaca mulatta	SCAP	VGNC	VGNC:77140
Others	SCAP	NCBI