Dok7 - docking protein 7 Gene

Also Known as Oit5; Dok-7; EF-12; A930013K19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 231134

Summary

Enables phosphatidylinositol binding activity and protein kinase binding activity. Involved in positive regulation of protein tyrosine kinase activity. Acts upstream of or within neuromuscular junction development; positive regulation of protein phosphorylation; and receptor clustering. Located in neuromuscular junction. Is expressed in several structures, including central nervous system; heart; skeletal muscle; and testis. Used to study congenital myasthenic syndrome 10. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 10 and fetal akinesia deformation sequence syndrome 3. Orthologous to human DOK7 (docking protein 7). [provided by Alliance of Genome Resources, Apr 2022]

Dok7 Products (5)

mRNA Protein Name
NM_001348274.1 NP_001335203.1 protein Dok-7 isoform 2
NM_001348275.1 NP_001335204.1 protein Dok-7 isoform 3
NM_001348276.1 NP_001335205.1 protein Dok-7 isoform 4
NM_001348478.1 NP_001335407.1 protein Dok-7 isoform 1
NM_172708.4 NP_766296.1 protein Dok-7 isoform 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol binding IDA
IDA: Inferred from direct assay
20603078 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16794080 MGI
enables protein kinase binding IDA
IDA: Inferred from direct assay
20603078 MGI
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
16794080 MGI
Biological Process GO Annotation Evidence References Source
involved in enzyme-linked receptor protein signaling pathway IDA
IDA: Inferred from direct assay
18848351 MGI
involved in enzyme-linked receptor protein signaling pathway IGI
IGI: Inferred from genetic interaction
8653787 MGI
involved in enzyme-linked receptor protein signaling pathway IMP
IMP: Inferred from mutant phenotype
14622576 MGI
acts upstream of or within neuromuscular junction development IDA
IDA: Inferred from direct assay
16794080 MGI
acts upstream of or within neuromuscular junction development IGI
IGI: Inferred from genetic interaction
16794080 MGI
involved in positive regulation of Rac protein signal transduction IDA
IDA: Inferred from direct assay
16794080 MGI
involved in positive regulation of Rac protein signal transduction IMP
IMP: Inferred from mutant phenotype
16794080 MGI
acts upstream of or within positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16794080 MGI
involved in positive regulation of protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
20603078 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IDA
IDA: Inferred from direct assay
18848351 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IGI
IGI: Inferred from genetic interaction
8653787 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
IMP: Inferred from mutant phenotype
14622576 MGI
acts upstream of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16794080 MGI
acts upstream of or within receptor clustering IDA
IDA: Inferred from direct assay
16794080 MGI
acts upstream of or within receptor clustering IGI
IGI: Inferred from genetic interaction
16794080 MGI
Cellular Component GO Annotation Evidence References Source
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
14622576 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
16794080 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
16794080 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Dok-7

  • downstream of tyrosine kinase 7

  • oncoprotein induced transcript 5

Dok7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Dok7 Q18PE0 Musk Mus musculus Q61006
Pull Down
20371544
Intra
Dok7 Q18PE0 Musk Mus musculus Q61006
ITC
20603078
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03939 DOK7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21324 Dok7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27843 Dok7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dok7 NCBI NCBI:285489