MLYCD - malonyl-CoA decarboxylase Gene

Also Known as MCD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23417

About MLYCD

Cytogenetic location: 16q23.3 Genomic coordinates (GRCh38): 16:83,899,115-83,927,031 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues and is associated with 3 phenotypes. Ubiquitous expression in heart (RPKM 24.2), liver (RPKM 11.1) and 24 other tissues.

Summary

The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008]

MLYCD Products (1)

mRNA Protein Name
NM_012213.3 NP_036345.2 malonyl-CoA decarboxylase, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
23791943 GOA
enables malonyl-CoA decarboxylase activity IDA
IDA: Inferred from direct assay
9869665 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in acetyl-CoA biosynthetic process IDA
IDA: Inferred from direct assay
9869665 GOA
involved in fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
15003260 GOA
involved in malonyl-CoA catabolic process IDA
IDA: Inferred from direct assay
10417274 GOA
involved in positive regulation of fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
18314420 GOA
involved in regulation of glucose metabolic process IMP
IMP: Inferred from mutant phenotype
18314420 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10455107 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
10417274 GOA
located in peroxisome IDA
IDA: Inferred from direct assay
10417274 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLYCD Protein Structure

MCD

MCD: Malonyl-CoA decarboxylase C-terminal domain (128 - 456)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
Protein Preferred Names Protein Names

malonyl-CoA decarboxylase, mitochondrial

  • malonyl coenzyme A decarboxylase

MLYCD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MLYCD O95822 MLYCD Homo sapiens O95822
Solution Sedimentation
23791943
Intra
MLYCD O95822 MLYCD Homo sapiens O95822
TEM
23791943
Intra
MLYCD O95822 MLYCD Homo sapiens O95822
X-Ray Diffraction
23791943
Intra
MLYCD O95822 MLYCD Homo sapiens O95822
GMS
23791943
Intra
MLYCD O95822 NUMA1 Homo sapiens Q14980
Crosslink
30021884
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Malonyl-Coa Decarboxylase Deficiency

  • Malonic Aciduria

  • Deficiency Of Malonyl-Coa Decarboxylase

  • Mcd Deficiency

  • Malonic Acidemia

  • Malonicaciduria

  • Malonyl-Coenzyme A Decarboxylase Deficiency

  • MLYCD DEFICIENCY
Combined Malonic And Methylmalonic Aciduria

  • CMAMMA

  • Combined Malonic And Methylmalonic Acidemia

  • Aciduria, Combined Malonic And Methylmalonic
Metabolic Acidosis
Alpha-Methylacyl-Coa Racemase Deficiency

  • Amacr Deficiency

  • AMACRD
Glutamate Formiminotransferase Deficiency

  • Formiminoglutamic Aciduria

  • Formiminotransferase Deficiency

  • FIGLU-URIA

  • Arakawa Syndrome 1

  • Formiminoglutamic Acidemia

  • Formiminotransferase Cyclodeaminase Deficiency

  • Formiminotransferase Deficiency Syndrome

  • Ftcd Deficiency

  • Formiminoglutamicaciduria

  • Figluria
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of

  • Vlcad Deficiency

  • Very Long Chain Acyl-Coa Dehydrogenase Deficiency

  • Very Long-Chain Acyl-Coenzyme A Dehydrogenase Deficiency

  • Lcad Deficiency

  • Very Long-Chain Acyl-Coa Dehydrogenase Deficiency

  • Long Chain Acyl-Coa Dehydrogenase Deficiency

  • ACADVLD

  • Acadl Deficiency

  • Vlcadd

  • Long-Chain Acyl-Coa Dehydrogenase Deficiency

  • Acadvl

  • Acyl-Coa Dehydrogenase Very Long Chain Deficiency

  • Very Long-Chain Acyl Coenzyme A Dehydrogenase Deficiency

  • Vlcad-C

  • Vlcad-H

  • Acyl-Coa Dehydrogenase, Very Long Chain, Deficiency Of

  • Acyl-Coa Dehydrogenase Very Long-Chain Deficiency

  • Acyl-Coa Dehydrogenase Long-Chain Deficiency

  • Deficiency, Very Long Chain Acyl-Coa Dehydrogenase

  • Long Chain/Very Long Chain Acyl Coa Dehydrogenase Deficiency
Multiple Acyl-Coa Dehydrogenase Deficiency

  • MADD

  • Ethylmalonic-Adipicaciduria

  • Ema

  • Glutaric Acidemia Iia

  • Glutaric Acidemia Iib

  • Ga Ii

  • Glutaric Acidemia Iic

  • Glutaric Acidemia Type 2

  • Glutaric Acidemia Ii

  • Glutaric Aciduria Ii

  • Electron Transfer Flavoprotein Deficiency

  • Glutaric Aciduria Type 2

  • Mad Deficiency

  • Glutaric Acidemia Type Ii

  • Glutaric Aciduria 2

  • Etfa Deficiency

  • Etfb Deficiency

  • Etfdh Deficiency

  • Multiple Acyl Coenzyme A Dehydrogenase Deficiency

  • Ga2

  • Electron Transfer Flavoprotein Ubiquinone Oxidoreductase Deficiency

  • Electron Transfer Flavoprotein Dehydrogenase Deficiency

  • Ga 2

  • Glutaric Acidemia 2

  • Glutaric Acidemia, Type 2

  • Glutaric Aciduria, Type 2

  • Mad

  • Multiple Fad Dehydrogenase Deficiency

  • Ethylmalonic Adipic Aciduria

  • Glutaricaciduria Ii

  • Glutaric Aciduria 2a

  • GA2A

  • Gaiia

  • Glutaricaciduria Iia

  • Glutaric Aciduria 2b

  • GA2B

  • Gaiib

  • Glutaricaciduria Iib

  • Glutaric Aciduria 2c

  • GA2C

  • Gaiic

  • Glutaricaciduria Iic

  • Glutaricaciduria, Type Iia

  • Glutaric Acidemia Type 2a

  • Glutaric Acidemia Type 2c

  • Glutaric Aciduria Iia

  • Glutaric Aciduria Iib

  • Glutaric Aciduria Iic
Constipation
Peroxisome Biogenesis Disorder 1b

  • Peroxisome Biogenesis Disorder

  • Infantile Refsum Disease

  • Infantile Phytanic Acid Storage Disease

  • PBD1B

  • Refsum Disease, Infantile

  • Adrenoleukodystrophy, Autosomal Neonatal

  • Ird

  • Mild Pbd-Zsd

  • Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

  • Pbd-Zsd

  • Peroxisome Biogenesis Disorder Spectrum

  • Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

  • Autosomal Neonatal Adrenoleukodystrophy

  • Refsum Disease Infantile

  • Peroxisome Biogenesis Disorders

  • Peroxisome Biogenesis Disorder, Type 1b
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08506 MLYCD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21650 Mlycd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28168 Mlycd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MLYCD RGD RGD:620234
Mus musculus MLYCD MGD MGI:1928485
Felis catus MLYCD VGNC VGNC:97511
Bos taurus MLYCD VGNC VGNC:97287
Canis familiaris MLYCD VGNC VGNC:57369
Others MLYCD NCBI