Fgl1 - fibrinogen-like protein 1 Gene

Also Known as Mfire1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 234199

Summary

Predicted to enable signaling receptor binding activity. Involved in negative regulation of T cell activation and regulation of immune response. Acts upstream of or within several processes, including adipose tissue development; Cholesterol metabolic process; and response to stilbenoid. Located in extracellular region. Orthologous to human FGL1 (fibrinogen like 1). [provided by Alliance of Genome Resources, Apr 2022]

Fgl1 Products (1)

mRNA Protein Name
NM_145594.2 NP_663569.2 fibrinogen-like protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
30580966 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
30580966 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adipose tissue development IMP
IMP: Inferred from mutant phenotype
23483972 MGI
acts upstream of or within cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
23483972 MGI
involved in negative regulation of T cell activation IDA
IDA: Inferred from direct assay
30580966 MGI
acts upstream of or within regulation of glucose metabolic process IMP
IMP: Inferred from mutant phenotype
23483972 MGI
involved in regulation of immune response IDA
IDA: Inferred from direct assay
30580966 MGI
involved in response to stilbenoid IEP
IEP: Inferred from expression pattern
17086191 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
30580966 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibrinogen-like protein 1

  • MFIRE-1

  • fibrinogen-related protein 1

  • liver fibrinogen-related protein-1

  • mfrep-1

Recombinant Fgl1 Proteins

Cat. No. Product Name Accession Purity
HY-P75188 FGL1 Protein, Mouse (sf9, His) Q71KU9 (L23-I314) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75189 FGL1 Protein, Mouse (HEK293, hFc) NP_663569.2 (L23-I314) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99156 Relatlimab 98.00% Phase 4

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-164308 SA-15-P Inhibitor 99.9% Unkown
HY-P11932 FGLP21 / Unkown
HY-RS04927 FGL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17106 Fgl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23550 Fgl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990243 Anti-Mouse FGL-1 Antibody (177R4) Ligand 96.31% Unkown
HY-P992352 ES005 / Unkown
HY-P992461 SHR-1802 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgl1 NCBI NCBI:2267