SMUG1 - single-strand-selective monofunctional uracil-DNA glycosylase 1 Gene

Also Known as FDG; UNG3; HMUDG

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23583

About SMUG1

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,158,235-54,188,985 (from NCBI)

This gene has 26 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in skin (RPKM 3.7), placenta (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011]

SMUG1 Products (32)

mRNA Protein Name
NM_001243787.2 NP_001230716.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001243788.2 NP_001230717.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001243789.2 NP_001230718.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001243790.2 NP_001230719.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001243791.2 NP_001230720.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351237.2 NP_001338166.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351238.2 NP_001338167.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351239.2 NP_001338168.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351240.2 NP_001338169.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351241.2 NP_001338170.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351242.2 NP_001338171.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351243.2 NP_001338172.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351244.2 NP_001338173.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351245.2 NP_001338174.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351246.2 NP_001338175.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351247.2 NP_001338176.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351248.2 NP_001338177.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351249.2 NP_001338178.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351250.2 NP_001338179.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351251.2 NP_001338180.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351252.2 NP_001338181.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351253.2 NP_001338182.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351254.2 NP_001338183.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351255.2 NP_001338184.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351256.2 NP_001338185.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351257.2 NP_001338186.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351258.2 NP_001338187.1 single-strand selective monofunctional uracil DNA glycosylase isoform 3
NM_001351259.2 NP_001338188.1 single-strand selective monofunctional uracil DNA glycosylase isoform 4
NM_001351260.2 NP_001338189.1 single-strand selective monofunctional uracil DNA glycosylase isoform 4
NM_001351261.2 NP_001338190.1 single-strand selective monofunctional uracil DNA glycosylase isoform 5
NM_001351262.2 NP_001338191.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_014311.3 NP_055126.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA N-glycosylase activity IDA
IDA: Inferred from direct assay
11526119 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables single-strand selective uracil DNA N-glycosylase activity IDA
IDA: Inferred from direct assay
12161446 GOA
enables uracil DNA N-glycosylase activity IDA
IDA: Inferred from direct assay
12718543 GOA
Biological Process GO Annotation Evidence References Source
involved in base-excision repair IDA
IDA: Inferred from direct assay
12161446 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
12161446 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMUG1 Protein Structure

UDG

UDG: Uracil DNA glycosylase superfamily (71 - 262)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

single-strand selective monofunctional uracil DNA glycosylase

SMUG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SMUG1 Q53HV7 VAC14 Homo sapiens Q08AM6
Y2H Array
29892012
Intra
SMUG1 Q53HV7 SKIL Homo sapiens P12757
Y2H Prey Pooling
26871637
Intra
SMUG1 Q53HV7 SKIL Homo sapiens P12757
Validated Y2H
26871637
Intra
SMUG1 Q53HV7 SKIL Homo sapiens P12757
Y2H Array
26871637
Intra
SMUG1 Q53HV7 CDC23 Homo sapiens Q9UJX2
Y2H Array
26871637
Intra
SMUG1 Q53HV7 CDC23 Homo sapiens Q9UJX2
Y2H Prey Pooling
26871637
Intra
SMUG1 Q53HV7 CDC23 Homo sapiens Q9UJX2
Validated Y2H
26871637
Intra
SMUG1 Q53HV7 RBPMS Homo sapiens Q93062
Pull Down
16189514
Intra
SMUG1 Q53HV7 CRX Homo sapiens O43186
Y2H Prey Pooling
26871637
Intra
SMUG1 Q53HV7 CRX Homo sapiens O43186
Validated Y2H
26871637
Intra
SMUG1 Q53HV7 CRX Homo sapiens O43186
Y2H Array
26871637
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SMUG1 Proteins

Cat. No. Product Name Accession Purity
HY-P71560 SMUG1 Protein, Human (His-SUMO) Q53HV7-2 (M1-L177) ≥ 90%, as determined by reducing SDS-PAGE.

SMUG1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810979 SMUG1 Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Rectosigmoid Junction Neoplasm

  • Neoplasm Of Rectosigmoid Junction

  • Rectosigmoid Neoplasm

  • Rectosigmoid Tumor

  • Rectosigmoid Carcinoma

  • Carcinoma Of The Rectosigmoid Junction

  • Malignant Tumor Of Rectosigmoid Junction

  • Rectosigmoid Junction Cancer

  • Primary Malignant Neoplasm Of Rectosigmoid Junction

  • Rectosigmoid Colon Cancer

  • Carcinoma Of Rectum With Sigmoid

  • Colorectal Cancer Nos

  • Colorectal Carcinoma Nos

  • Rectosigmoid Cancer
Immunodeficiency With Hyper-Igm, Type 5

  • HIGM5

  • Hyper-Igm Syndrome 5

  • Immunodeficiency With Hyper Igm Type 5

  • Hyper-Igm Syndrome Type 5

  • Hyper-Igm Syndrome Due To Ung Deficiency

  • Hyper-Igm Syndrome Due To Uracil N-Glycosylase

  • Immunodeficiency With Hyper Igm, Type 5

  • Hyper Igm Syndrome 5

  • Immunodeficiency With Hyper-Igm 5

  • Hyper-Igm Immunodeficiency Type 5

  • Immunodeficiency, With Hyper Igm, Type 5

  • Hyper-Igm Immunodeficiency Syndrome, Type 5
Sigmoid Neoplasm

  • Sigmoid Neoplasms

  • Neoplasm Of Sigmoid Colon

  • Tumor Of Sigmoid Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-184013 SU0617 Inhibitor / Unkown
HY-RS13458 SMUG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20492 Smug1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27000 Smug1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SMUG1 VGNC VGNC:65509
Rattus norvegicus SMUG1 RGD RGD:631403
Mus musculus SMUG1 MGD MGI:1918976
Bos taurus SMUG1 VGNC VGNC:35039
Macaca mulatta SMUG1 VGNC VGNC:77730
Canis familiaris SMUG1 VGNC VGNC:46579
Others SMUG1 NCBI