CLEC5A - C-type lectin domain containing 5A Gene

Also Known as MDL1; MDL-1; CLECSF5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23601

About CLEC5A

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:141,927,357-141,946,974 (from NCBI)

This gene has 7 transcripts (splice variants), 224 orthologues and 23 paralogues. Biased expression in bone marrow (RPKM 12.6), appendix (RPKM 4.1) and 6 other tissues.

Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008]

CLEC5A Products (2)

mRNA Protein Name
NM_001301167.2 NP_001288096.1 C-type lectin domain family 5 member A isoform 2
NM_013252.3 NP_037384.1 C-type lectin domain family 5 member A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables virus receptor activity IDA
IDA: Inferred from direct assay
18496526 GOA
Biological Process GO Annotation Evidence References Source
involved in innate immune response IDA
IDA: Inferred from direct assay
18496526 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC5A Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (90 - 185)

  • 0
  • 100
  • 188 a.a.
Protein Preferred Names Protein Names

C-type lectin domain family 5 member A

  • C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5

Recombinant CLEC5A Proteins

Cat. No. Product Name Accession Purity
HY-P77632 CLEC5A/MDL-1 Protein, Human (HEK293, Fc) Q9NY25 (Y26-K188) ≥ 95%, as determined by Bis-Tris PAGE.

CLEC5A Antibodies

Cat. No. Product Name Application Reactivity
HY-P84835 CLEC5A Antibody (YA4532) WB, FC, ELISA Human
HY-P84835A CLEC5A Antibody (YA4532)(PBS only) WB, FC, ELISA Human

Related Diseases

Diseases Alias
Dengue Virus

  • Dengue Virus, Susceptibility To

  • Dengue Fever, Protection Against

  • Dengue Fever
Dengue Hemorrhagic Fever

  • Severe Dengue

  • Dengue Haemorrhagic Fever

  • Dhf

  • Severe Dengue Haemorrhagic Fever

  • Severe Dengue Fever

  • Dengue Shock Syndrome
Dengue Shock Syndrome

  • Dss
Dengue Disease

  • Dengue Fever

  • Dengue

  • Df

  • Dengue Shock Syndrome

  • Dengue Virus Infection

  • Breakbone Fever

  • Classic Dengue

  • Classical Dengue

  • Dengue Hemorrhagic Fever

  • Hemorrhagic Dengue

  • Philippine Hemorrhagic Fever

  • Singapore Hemorrhagic Fever

  • Thai Hemorrhagic Fever

  • Severe Dengue

  • Dengue Fever Without Warning Signs

  • Dengue Haemorrhagic Fever Grade 1

  • Dengue Haemorrhagic Fever Without Warning Signs

  • Bangkok Haemorrhagic Fever

  • Singapore Haemorrhagic Fever

  • Thailand Haemorrhagic Fever

  • Southeast Asia Haemorrhagic Fever

  • Dhf -[Dengue Haemorrhagic Fever]

  • Dengue Fever With Warning Signs

  • Dengue Haemorrhagic Fever With Warning Signs

  • Dengue Haemorrhagic Fever Grade 2

  • Philippine Haemorrhagic Fever
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

  • Nasu-Hakola Disease

  • Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

  • Plosl

  • Nhd

  • Presenile Dementia With Bone Cysts

  • Plo-Sl

  • PLOSL1

  • Dementia, Prefrontal, With Bone Cysts

  • Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

  • Brain-Bone-Fat Disease

  • Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

  • Brain-Bone-Fat Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2110 Phellopterin 99.94% Unkown
HY-184358 CLEC5A-IN-1 / Unkown
HY-RS02798 CLEC5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18419 Clec5a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24900 Clec5a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CLEC5A VGNC VGNC:39334
Felis catus CLEC5A VGNC VGNC:60954
Mus musculus CLEC5A MGD MGI:1345151
Rattus norvegicus CLEC5A RGD RGD:1584755
Bos taurus CLEC5A VGNC VGNC:27435
Macaca mulatta CLEC5A VGNC VGNC:71252
Others CLEC5A NCBI