Npc1l1 - NPC1 like intracellular cholesterol transporter 1 Gene

Also Known as Gm243; 9130221N23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 237636

Summary

Predicted to enable heterocyclic compound binding activity; Myosin V binding activity; and small GTPase binding activity. Acts upstream of or within Cholesterol homeostasis. Predicted to be located in brush border membrane. Predicted to be spanning component of plasma membrane. Orthologous to human NPC1L1 (NPC1 like intracellular Cholesterol transporter 1). [provided by Alliance of Genome Resources, Apr 2022]

Npc1l1 Products (1)

mRNA Protein Name
NM_207242.2 NP_997125.2 NPC1-like intracellular cholesterol transporter 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
29880681 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
14976318 MGI
involved in cholesterol transport IMP
IMP: Inferred from mutant phenotype
14976318 MGI
involved in intestinal cholesterol absorption IMP
IMP: Inferred from mutant phenotype
14976318 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NPC1-like intracellular cholesterol transporter 1

  • NPC1-like 1

  • Niemann-Pick disease, type C1

  • Niemann-Pick disease, type C1-like 1

  • niemann-Pick C1-like protein 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17376 Ezetimibe 99.95% Yes

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99362 Ensituximab Inhibitor 99.93% Phase 2

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-113315 3b-Hydroxy-5-cholenoic acid 99.93% Unkown
HY-17376S Ezetimibe-d4 98.84% Unkown
HY-136059 Desfluoro-ezetimibe Activator 99.54% Unkown
HY-17376R Ezetimibe (Standard) 99.90% Unkown
HY-17640 Nicodicosapent Inhibitor 99.79% Unkown
HY-17376S1 Ezetimibe-d4-1 99.26% Unkown
HY-135388 ent-Ezetimibe / Unkown
HY-160882 EBOV-IN-7 / Unkown
HY-17376S3 Ezetimibe-13C6 / Unkown
HY-N18304 Brutieridin Inhibitor / Unkown
HY-RS09475 NPC1L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121315 BRD4097 Inhibitor / Unkown
HY-RS17515 Npc1l1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23972 Npc1l1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Npc1l1 NCBI NCBI:29881