Ets1 - E26 avian leukemia oncogene 1, 5' domain Gene

Also Known as vs; p54; Tpl1; Ets-1; D230050P06

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23871

Summary

Enables DNA-binding transcription factor activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of inflammatory response. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ETS1 (ETS proto-oncogene 1, transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Ets1 Products (6)

mRNA Protein Name
NM_001038642.2 NP_001033731.1 protein C-ets-1 isoform 2
NM_001372534.1 NP_001359463.1 protein C-ets-1 isoform 3
NM_001372535.1 NP_001359464.1 protein C-ets-1 isoform 4
NM_001372536.1 NP_001359465.1 protein C-ets-1 isoform 5
NM_001372537.1 NP_001359466.1 protein C-ets-1 isoform 6
NM_011808.3 NP_035938.2 protein C-ets-1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
7774816 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12119294 MGI
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
9199349 MGI
enables nucleic acid binding EXP
EXP: Inferred from Experiment
15994560 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7774816 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
1409581 MGI
enables sequence-specific double-stranded DNA binding IMP
IMP: Inferred from mutant phenotype
15994560 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
22294049 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12464608 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12119294 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
12464608 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15541767 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12119294 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
12464608 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein C-ets-1

  • avian erythroblastosis virus E26 oncogene 1

  • tumor progression locus 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W002199 6:2 Fluorotelomer alcohol 99.96% Unkown
HY-RS04562 ETS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16879 Ets1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23321 Ets1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28129 Kcnh8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ets1 NCBI NCBI:2113