Grem2 - gremlin 2, DAN family BMP antagonist Gene

Also Known as Prdc; Gremlin2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23893

Summary

Enables BMP binding activity; heparin binding activity; and identical protein binding activity. Involved in several processes, including determination of dorsal identity; embryonic body morphogenesis; and regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including chondrocranium; integument; intestine smooth muscle circular layer; lung; and neural tube. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human GREM2 (gremlin 2, Dan family BMP antagonist). [provided by Alliance of Genome Resources, Apr 2022]

Grem2 Products (1)

mRNA Protein Name
NM_011825.1 NP_035955.1 gremlin-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables BMP binding IMP
IMP: Inferred from mutant phenotype
23063586 MGI
enables heparin binding IDA
IDA: Inferred from direct assay
23850456 MGI
enables identical protein binding IMP
IMP: Inferred from mutant phenotype
23063586 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
23850456 MGI
Biological Process GO Annotation Evidence References Source
involved in cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
23850456 MGI
involved in determination of dorsal identity IMP
IMP: Inferred from mutant phenotype
23063586 MGI
involved in embryonic body morphogenesis IMP
IMP: Inferred from mutant phenotype
23850456 MGI
involved in negative regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
23063586 MGI
involved in regulation of cytokine activity IMP
IMP: Inferred from mutant phenotype
23850456 MGI
involved in sequestering of BMP from receptor via BMP binding IMP
IMP: Inferred from mutant phenotype
23063586 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IMP
IMP: Inferred from mutant phenotype
23063586 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gremlin-2

  • Gremlin1

  • cysteine knot superfamily 1, BMP antagonist 2

  • gremlin 2 homolog, cysteine knot superfamily

  • protein related to DAN and cerberus

Recombinant Grem2 Proteins

Cat. No. Product Name Accession Purity
HY-P79104 PRDC/GREM2 Protein, Mouse O88273/NP_035955 (R22-Q168) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05785 GREM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20945 Grem2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27462 Grem2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grem2 NCBI NCBI:64388