Ada - adenosine deaminase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24165

About Ada

Primary_assembly 3: 152,398,747-152,447,088 reverse strand.mRatBN7.2:CM026976.1

This gene has 4 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 51 phenotypes. Biased expression in Lung (RPKM 737.7), Thymus (RPKM 689.8) and 7 other tissues.

Summary

Enables Adenosine Deaminase activity and purine nucleoside binding activity. Involved in several processes, including adenosine metabolic process; negative regulation of circadian sleep/wake cycle, non-REM sleep; and response to vitamin E. Located in dendrite cytoplasm; extracellular space; and neuronal cell body. Used to study hypertension; peritonitis; and pulmonary edema. Biomarker of hyperglycemia; leptospirosis; lung disease; and trypanosomiasis. Human ortholog(s) of this gene implicated in Adenosine Deaminase deficiency; asthma; and severe combined immunodeficiency. Orthologous to human ADA (Adenosine Deaminase). [provided by Alliance of Genome Resources, Apr 2022]

Ada Products (1)

mRNA Protein Name
NM_130399.2 NP_569083.1 adenosine deaminase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables adenosine deaminase activity IDA
IDA: Inferred from direct assay
3746429 RGD
enables purine nucleoside binding IDA
IDA: Inferred from direct assay
3746429 RGD
Biological Process GO Annotation Evidence References Source
involved in adenosine catabolic process IMP
IMP: Inferred from mutant phenotype
30269308 RGD
involved in adenosine metabolic process IDA
IDA: Inferred from direct assay
3746429 RGD
involved in histamine secretion IMP
IMP: Inferred from mutant phenotype
19066225 RGD
involved in negative regulation of circadian sleep/wake cycle, non-REM sleep IMP
IMP: Inferred from mutant phenotype
19066225 RGD
involved in regulation of T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
3876160 RGD
involved in regulation of circadian sleep/wake cycle, sleep IEP
IEP: Inferred from expression pattern
11038259 RGD
involved in response to L-arginine IEP
IEP: Inferred from expression pattern
22623885 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
27491636 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
15966013 RGD
involved in response to hypoxia IMP
IMP: Inferred from mutant phenotype
20735412 RGD
involved in response to vitamin E IDA
IDA: Inferred from direct assay
16716042 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16716042 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite cytoplasm IDA
IDA: Inferred from direct assay
2253038 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
16563876 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
2253038 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ada Protein Structure

A_deaminase

A_deaminase: pfam00962 (9 - 348)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
Protein Preferred Names Protein Names

adenosine deaminase

  • adenosine aminohydrolase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-17377 Vicriviroc maleate 99.91% Phase 3
HY-137294 BTPTT-4F 98.0% Phase 3
HY-105017 Evodenoson Agonist 99.94% Phase 2
HY-19130 BW-534U87 Agonist / Phase 2

Pre-clinical Phase

Bioactive Molecules (25)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103160A EHNA hydrochloride Inhibitor 99.67% Unkown
HY-158009 SGF29-IN-1 Inhibitor 98.0% Unkown
HY-W011552 2'-O-Methyladenosine 99.76% Unkown
HY-N7368 Hibifolin Inhibitor 99.70% Unkown
HY-103237 L-Adenosine Inhibitor 99.82% Unkown
HY-D0855A ADA disodium 98.0% Unkown
HY-103159 1-Deazaadenosine Inhibitor 98.9% Unkown
HY-114175A Adenosine deaminase, Calf Spleen / Unkown
HY-D0855 ADA 98.53% Unkown
HY-W753672 2'-O-Methyladenosine-d3 97.54% Unkown
HY-181065 LS-170 Inhibitor / Unkown
HY-117260 Coformycin Inhibitor / Unkown
HY-103160B EHNA Inhibitor / Unkown
HY-P11846 ADA2 Ligand / Unkown
HY-P5201S VTSEGAGLQLQK-13C6,15N2 / Unkown
HY-RS00258 ADA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00259 Ada Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00260 Ada Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00261 ADA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W011552S 2'-O-Methyladenosine-d / Unkown
HY-W011552S1 2'-O-Methyladenosine-d2 / Unkown
HY-W011552S2 2'-O-Methyladenosine-d-1 / Unkown
HY-W129499 ADA sodium / Unkown
HY-133216 Bupirimate Inhibitor 99.77% Unkown
HY-180366 5-Amino-2'-deoxyuridine / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991440 AMG-966 Inhibitor 98.38% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ada NCBI NCBI:100