Adrb2 - adrenoceptor beta 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24176

Summary

Enables several functions, including G-protein alpha-subunit binding activity; beta2-adrenergic receptor activity; and signaling receptor binding activity. Involved in several processes, including chemical synaptic transmission; positive regulation of ion transport; and response to steroid hormone. Located in several cellular components, including caveola; neuronal cell body membrane; and sarcolemma. Is active in glutamatergic synapse. Used to study cardiomyopathy (multiple); congestive heart failure; kidney disease (multiple); and lung disease (multiple). Biomarker of several diseases, including acute kidney failure; artery disease (multiple); congestive heart failure; polycystic ovary syndrome; and ulcerative colitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); disease of metabolism (multiple); kidney failure (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Orthologous to human ADRB2 (adrenoceptor beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Adrb2 Products (1)

mRNA Protein Name
NM_012492.2 NP_036624.2 beta-2 adrenergic receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables B2 bradykinin receptor binding IPI
IPI: Inferred from physical interaction
20150590 RGD
enables G-protein alpha-subunit binding IPI
IPI: Inferred from physical interaction
19942860 RGD
enables beta2-adrenergic receptor activity IDA
IDA: Inferred from direct assay
6247002 RGD
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
19942860 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11441182 RGD
enables protein phosphatase 2A binding IPI
IPI: Inferred from physical interaction
20395454 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15141163 RGD
enables receptor-receptor interaction IPI
IPI: Inferred from physical interaction
20395454 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12514203 RGD
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
2153813 RGD
involved in associative learning IDA
IDA: Inferred from direct assay
2573754 RGD
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
19098126 RGD
involved in diaphragm contraction IDA
IDA: Inferred from direct assay
17362795 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
7977723 RGD
involved in excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
17175110 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
7977723 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
8408243 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
8855951 RGD
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
22495178 RGD
involved in negative regulation of ossification IMP
IMP: Inferred from mutant phenotype
16177600 RGD
involved in negative regulation of urine volume IMP
IMP: Inferred from mutant phenotype
7912752 RGD
involved in positive regulation of ATP-dependent activity IMP
IMP: Inferred from mutant phenotype
8760245 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15591297 RGD
involved in positive regulation of calcium ion import across plasma membrane IDA
IDA: Inferred from direct assay
11408541 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
16005083 RGD
involved in positive regulation of potassium ion transport IDA
IDA: Inferred from direct assay
6247002 RGD
involved in positive regulation of skeletal muscle tissue growth IMP
IMP: Inferred from mutant phenotype
16177600 RGD
involved in positive regulation of sodium ion transport IDA
IDA: Inferred from direct assay
6247002 RGD
involved in positive regulation of the force of heart contraction by epinephrine IDA
IDA: Inferred from direct assay
19133992 RGD
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
17175110 RGD
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
17175110 RGD
involved in regulation of calcium ion transport IDA
IDA: Inferred from direct assay
12514203 RGD
involved in response to catecholamine IDA
IDA: Inferred from direct assay
6381693 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
7588441 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
11431147 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
21562317 RGD
involved in response to monoamine IEP
IEP: Inferred from expression pattern
1664493 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
1314813 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
2845194 RGD
involved in synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
17175110 RGD
involved in vasodilation IDA
IDA: Inferred from direct assay
15351777 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
11441182 RGD
located in axon IDA
IDA: Inferred from direct assay
15682824 RGD
located in caveola IDA
IDA: Inferred from direct assay
15961389 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15682824 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
11441182 RGD
located in endosome IDA
IDA: Inferred from direct assay
12932836 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
17175110 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17175110 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
11441182 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
11441182 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
15961389 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-2 adrenergic receptor

  • Adrenergic beta 2- receptor surface

  • adrenergic receptor, beta 2

  • adrenergic, beta-2-, receptor, surface

  • adrenoceptor beta 2, surface

  • beta-2 adrenoceptor

  • beta-2 adrenoreceptor

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14299 Indacaterol Agonist 99.98% Unkown
HY-14299A Indacaterol maleate Agonist 99.82% Unkown
HY-14299D Indacaterol acetate Agonist / Unkown

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13338 Mabuterol Agonist 99.96% Unkown
HY-RS00415 ADRB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16956 Adrb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-14299B (S)-Indacaterol / Unkown
HY-152051S Mabuterol-d9 hydrochloride Agonist / Unkown
HY-RS23399 Adrb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W755295 Mabuterol hydrochloride Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adrb2 NCBI NCBI:154