Afp - alpha-fetoprotein Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24177

Summary

Predicted to enable fatty acid binding activity and zinc ion binding activity. Involved in several processes, including cellular response to retinoic acid; liver regeneration; and response to dexamethasone. Located in cytosol and extracellular space. Biomarker of hepatitis. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human AFP (alpha fetoprotein). [provided by Alliance of Genome Resources, Apr 2022]

Afp Products (1)

mRNA Protein Name
NM_012493.2 NP_036625.2 alpha-fetoprotein precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
17828713 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
7539613 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
16822301 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
2460696 RGD
involved in pancreas development IEP
IEP: Inferred from expression pattern
17880577 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
2409527 RGD
involved in response to tetrachloromethane IEP
IEP: Inferred from expression pattern
1711115 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
1711115 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-fetoprotein

  • alpha-1-fetoprotein

  • alpha-fetoglobulin

  • chloride intracellular channel 6

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0600 Tafluprost Control 99.69% Yes
HY-B0601 Tafluprost acid 99.88% Unkown
HY-116733 Tafluprost ethyl ester Agonist / Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-16031B AFP464 dihydrochloride 99.45% Phase 2
HY-16031 AFP464 free base / Phase 2
HY-16031A AFP464 / Phase 2

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103469 Peroxy Orange 1 99.20% Unkown
HY-175606 EVT0185 Inhibitor 99.39% Unkown
HY-160042 AFP aptamer sodium 94.04% Unkown
HY-105315 AFP-07 Agonist / Unkown
HY-129293 AFP-07 free acid Agonist / Unkown
HY-NP228 Alpha fetoprotein, human / Unkown
HY-RS00435 AFP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15031 TRIM26 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-160042A AFP aptamer sodium scrambled negative control / Unkown
HY-160042B FAM labled AFP aptamer sodium / Unkown
HY-160042C Cy3 labled AFP aptamer sodium / Unkown
HY-RS16874 Afp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23316 Afp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991858 Anti-AFP Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Afp NCBI NCBI:174