Pde5a - phosphodiesterase 5A, cGMP-specific Gene

Also Known as Cn5n; Pde5; Cgbpde; PDE5a2; Pde5a1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 242202

About Pde5a

Chromosome 3: 122,522,596-122,653,023 forward strand.GRCm39:CM000996.3

This gene has 4 transcripts (splice variants), 207 orthologues, 20 paralogues and is associated with 11 phenotypes. Biased expression in bladder adult (RPKM 49.4), lung adult (RPKM 12.8) and 6 other tissues.

Summary

Enables 3',5'-cyclic-nucleotide phosphodiesterase activity and cGMP binding activity. Involved in positive regulation of MAP kinase activity; regulation of muscle system process; and relaxation of cardiac muscle. Acts upstream of or within several processes, including cGMP catabolic process; negative regulation of T cell proliferation; and positive regulation of oocyte development. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human PDE5A (phosphodiesterase 5A). [provided by Alliance of Genome Resources, Apr 2022]

Pde5a Products (2)

mRNA	Protein	Name
NM_001409793.1	NP_001396722.1	cGMP-specific 3',5'-cyclic phosphodiesterase isoform 2
NM_153422.3	NP_700471.2	cGMP-specific 3',5'-cyclic phosphodiesterase isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IMP IMP: Inferred from mutant phenotype	19474061	MGI
enables cGMP binding	IDA IDA: Inferred from direct assay	12554648	MGI
enables cyclic-nucleotide phosphodiesterase activity	IDA IDA: Inferred from direct assay	12554648	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of T cell proliferation	IMP IMP: Inferred from mutant phenotype	17101732	MGI
acts upstream of or within cGMP catabolic process	IDA IDA: Inferred from direct assay	12554648	MGI
acts upstream of or within cGMP metabolic process	IMP IMP: Inferred from mutant phenotype	19474061	MGI
acts upstream of or within negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	17101732	MGI
involved in negative regulation of cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	19127022	MGI
acts upstream of oocyte development	IGI IGI: Inferred from genetic interaction	19474061	MGI
acts upstream of oocyte development	IMP IMP: Inferred from mutant phenotype	19474061	MGI
involved in positive regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	19127022	MGI
involved in positive regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	19127022	MGI
acts upstream of or within positive regulation of oocyte development	IGI IGI: Inferred from genetic interaction	19474061	MGI
acts upstream of or within positive regulation of oocyte development	IMP IMP: Inferred from mutant phenotype	19474061	MGI
acts upstream of or within regulation of nitric oxide mediated signal transduction	IGI IGI: Inferred from genetic interaction	16150726	MGI
involved in relaxation of cardiac muscle	IMP IMP: Inferred from mutant phenotype	19127022	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pde5a Protein Structure

GAF

PDEase_I

0
200
400
600
800
865 a.a.

Protein Preferred Names	Protein Names
cGMP-specific 3',5'-cyclic phosphodiesterase	cGMP-binding cGMP-specific phosphodiesterase

Recombinant Pde5a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71591	cGB-PDE Protein, Mouse (Myc, His)	Q8CG03 (D154-N320)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-106230A	Dasantafil	Inhibitor	98.35%	Phase 2
HY-112831	Osoresnontrine	Inhibitor	99.94%	Phase 2
HY-170435	PDE5-IN-13	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N1343	Robustine	Inhibitor	99.70%	Unkown
HY-103084	PDE5-IN-1	Inhibitor	/	Unkown
HY-161851	MDL3	Inhibitor	/	Unkown
HY-N17363	Confusameline		/	Unkown
HY-RS10227	PDE5A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10228	Pde5a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10229	Pde5a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pde5a	NCBI	NCBI:8654