Cebpb - CCAAT/enhancer binding protein beta Gene

Also Known as TCF5; Il6dbp; NF-IL6

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24253

Summary

This intronless gene encodes a member of the transcription factor family whose members contain a basic leucine-zipper domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. The encoded protein plays important roles in several cellular processes and in various diseases, including regulating cell proliferation, differentiation, Apoptosis and neuroinflammation, and being involved in brain injury and inflammatory progression. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with different cellular localizations and distinct biological functions. [provided by RefSeq, Sep 2014]

Cebpb Products (3)

mRNA	Protein	Name
NM_001301715.1	NP_001288644.1	CCAAT/enhancer-binding protein beta isoform LAP2
NM_001301720.1	NP_001288649.1	CCAAT/enhancer-binding protein beta isoform LIP
NM_024125.5	NP_077039.3	CCAAT/enhancer-binding protein beta isoform LAP1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	1377818	RGD
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8572170	RGD
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15661831	RGD
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15308669	RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8572170	RGD
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	1547942	RGD
enables nuclear glucocorticoid receptor binding	IPI IPI: Inferred from physical interaction	20155810	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	1377818	RGD
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	1547942	RGD
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	2171780	RGD
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	8367486	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14661739	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to interleukin-1	IDA IDA: Inferred from direct assay	18405661	RGD
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	18405661	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	21877759	RGD
involved in hepatocyte proliferation	IDA IDA: Inferred from direct assay	10635333	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	1377818	RGD
involved in memory	IEP IEP: Inferred from expression pattern	17512093	RGD
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15308669	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16445384	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8572170	RGD
involved in regulation of odontoblast differentiation	IDA IDA: Inferred from direct assay	15308669	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of CHOP-C/EBP complex	IPI IPI: Inferred from physical interaction	1547942	RGD
located in nuclear matrix	IDA IDA: Inferred from direct assay	12095231	RGD
located in nucleus	IDA IDA: Inferred from direct assay	8657121	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
CCAAT/enhancer-binding protein beta	C/EBP beta CCAAT/enhancer binding protein (C/EBP), beta IL-6DBP SF-B interleukin-6-dependent-binding protein nuclear factor-IL6 silencer factor B

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02446	CEBPB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23873	Cebpb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17419	Cebpb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cebpb	NCBI	NCBI:1051