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EDNRA - endothelin receptor type A Gene

Also Known as Eta; ET-A; ET-AR; Endor; RGD1559432

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24326

About EDNRA

Primary_assembly 19: 30,233,571-30,297,049 forward strand.mRatBN7.2:CM026992.1

This gene has 5 transcripts (splice variants), 268 orthologues, 14 paralogues and is associated with 41 phenotypes. Biased expression in Lung (RPKM 125.), Heart (RPKM 74.4) and 7 other tissues.

Summary

Enables Endothelin Receptor activity. Involved in several processes, including cellular response to mechanical stimulus; glomerular filtration; and positive regulation of cytosolic calcium ion concentration. Located in T-tubule and nuclear membrane. Colocalizes with membrane raft. Used to study hypertension; myocardial infarction; portal hypertension; pulmonary emphysema; and pulmonary hypertension. Biomarker of several diseases, including hyperhomocysteinemia; impotence; obstructive sleep apnea; renal fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (Endothelin Receptor type A). [provided by Alliance of Genome Resources, Apr 2022]

EDNRA Products (1)

mRNA	Protein	Name
NM_012550.2	NP_036682.1	endothelin-1 receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables endothelin receptor activity	IDA IDA: Inferred from direct assay	1849646	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	16543720	RGD
involved in cellular response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	18320471	RGD
involved in fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	19878520	RGD
involved in glomerular filtration	IMP IMP: Inferred from mutant phenotype	20823379	RGD
involved in histamine secretion	IMP IMP: Inferred from mutant phenotype	18787779	RGD
involved in maternal process involved in parturition	IEP IEP: Inferred from expression pattern	18948426	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19270827	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12628492	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	16543720	RGD
involved in positive regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	12628492	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19270827	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	1849646	RGD
involved in positive regulation of kidney development	IMP IMP: Inferred from mutant phenotype	19270827	RGD
involved in positive regulation of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	18787779	RGD
involved in positive regulation of odontogenesis	IMP IMP: Inferred from mutant phenotype	16843458	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	12907462	RGD
involved in positive regulation of release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	12628492	RGD
involved in regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	12538737	RGD
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	20397012	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19851775	RGD
involved in smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	16543720	RGD
involved in vasoconstriction	IMP IMP: Inferred from mutant phenotype	14678950	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in T-tubule	IDA IDA: Inferred from direct assay	12972433	RGD
located in nuclear membrane	IDA IDA: Inferred from direct assay	12756260	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EDNRA Protein Structure

7tmA_ET-AR

0
100
200
300
400
426 a.a.

Protein Preferred Names	Protein Names
endothelin-1 receptor	endothelin A receptor endothelin-1 receptor-like

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990089	Patecibart	Antagonist	97.77%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04166	EDNRA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04167	Ednra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04168	EDNRA Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04171	Ednrb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	EDNRA	NCBI	NCBI:1909