Gck - glucokinase Gene

Also Known as GLK; GLUKA; RNGK2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24385

About Gck

Primary_assembly 14: 80,785,060-80,826,995 reverse strand.mRatBN7.2:CM026987.1

This gene has 4 transcripts (splice variants), 214 orthologues, 4 paralogues and is associated with 29 phenotypes. Biased expression in Liver (RPKM 79.4) and Heart (RPKM 6.).

Summary

Enables several functions, including adenyl ribonucleotide binding activity; glucose binding activity; and Hexokinase activity. Involved in several processes, including cellular chemical homeostasis; cellular response to hormone stimulus; and hexose metabolic process. Located in several cellular components, including basal cortex; nucleoplasm; and secretory granule. Colocalizes with actin filament. Used to study fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (Glucokinase). [provided by Alliance of Genome Resources, Apr 2022]

Gck Products (3)

mRNA Protein Name
NM_001270849.1 NP_001257778.1 hexokinase-4 isoform 1
NM_001270850.1 NP_001257779.1 hexokinase-4 isoform 3
NM_012565.2 NP_036697.1 hexokinase-4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ADP binding IDA
IDA: Inferred from direct assay
12513690 RGD
enables ATP binding IDA
IDA: Inferred from direct assay
12513690 RGD
enables D-glucose binding IDA
IDA: Inferred from direct assay
4273555 RGD
enables D-glucose binding IPI
IPI: Inferred from physical interaction
12513690 RGD
enables fructokinase activity IDA
IDA: Inferred from direct assay
6477520 RGD
enables glucokinase activity IDA
IDA: Inferred from direct assay
4273555 RGD
enables glucose sensor activity IDA
IDA: Inferred from direct assay
17470517 RGD
enables magnesium ion binding IDA
IDA: Inferred from direct assay
12513690 RGD
enables mannokinase activity IDA
IDA: Inferred from direct assay
7742312 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10601273 RGD
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
10913113 RGD
Biological Process GO Annotation Evidence References Source
involved in carbohydrate phosphorylation IDA
IDA: Inferred from direct assay
9109397 RGD
involved in cellular response to glucose starvation IMP
IMP: Inferred from mutant phenotype
18292346 RGD
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
17470517 RGD
involved in cellular response to leptin stimulus IDA
IDA: Inferred from direct assay
17470517 RGD
involved in fructose 2,6-bisphosphate metabolic process IDA
IDA: Inferred from direct assay
17553851 RGD
involved in fructose 6-phosphate metabolic process IDA
IDA: Inferred from direct assay
6477520 RGD
involved in glucose 6-phosphate metabolic process IDA
IDA: Inferred from direct assay
4273555 RGD
involved in glucose metabolic process IDA
IDA: Inferred from direct assay
17553851 RGD
involved in glycogen biosynthetic process IDA
IDA: Inferred from direct assay
17028192 RGD
involved in glycolytic process IDA
IDA: Inferred from direct assay
4273555 RGD
involved in intracellular glucose homeostasis IMP
IMP: Inferred from mutant phenotype
16443775 RGD
involved in lipid homeostasis IDA
IDA: Inferred from direct assay
22925001 RGD
involved in mannose metabolic process IDA
IDA: Inferred from direct assay
7742312 RGD
involved in negative regulation of epinephrine secretion IMP
IMP: Inferred from mutant phenotype
18292346 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
17360975 RGD
involved in positive regulation of glycolytic process IDA
IDA: Inferred from direct assay
17553851 RGD
involved in positive regulation of insulin secretion IDA
IDA: Inferred from direct assay
17028192 RGD
involved in positive regulation of phosphorylation IDA
IDA: Inferred from direct assay
17553851 RGD
involved in regulation of glucose mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
16443775 RGD
involved in response to glucose IDA
IDA: Inferred from direct assay
17470517 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
12086933 RGD
Cellular Component GO Annotation Evidence References Source
located in actin filament IDA
IDA: Inferred from direct assay
9109397 RGD
located in basal cortex IDA
IDA: Inferred from direct assay
10071239 RGD
located in cell cortex IDA
IDA: Inferred from direct assay
12369705 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
10601273 RGD
located in nucleoplasm IDA
IDA: Inferred from direct assay
12369705 RGD
located in nucleus IDA
IDA: Inferred from direct assay
10601273 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
9357983 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gck Protein Structure

Hexokinase_1

Hexokinase_1: pfam00349 (99 - 247)

Hexokinase_2

Hexokinase_2: pfam03727 (253 - 487)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 498 a.a.
Protein Preferred Names Protein Names

hexokinase-4

  • HK IV

  • HK4

  • hexokinase type IV

  • hexokinase-D

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147141 HS-276 Inhibitor 98.93% Unkown
HY-15489 Scriptaid 98.59% Unkown
HY-10943 GNF-7 Inhibitor 99.70% Unkown
HY-123714 TL4-12 99.82% Unkown
HY-137342 SB1-G-187 Degrader 98.70% Unkown
HY-137343 DB-0646 Degrader 98.0% Unkown
HY-RS04706 FAM20C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-147141A HS-276 hydrochloride Inhibitor / Unkown
HY-147141B HS-276 formic Inhibitor / Unkown
HY-170365 HPK1-IN-55 Inhibitor / Unkown
HY-183809 ZSW Inhibitor / Unkown
HY-RS05329 GCK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05330 Gck Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05331 Gck Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08074 MAP4K2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08075 Map4k2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gck NCBI NCBI:2645