2. Gene
  3. Gck - glucokinase Gene

Gck - glucokinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as GLK; GLUKA; RNGK2

Gene ID: 24385 | Gene type: protein coding

About Gck

Primary_assembly 14: 80,785,060-80,826,995 reverse strand.mRatBN7.2:CM026987.1

This gene has 4 transcripts (splice variants), 214 orthologues, 4 paralogues and is associated with 29 phenotypes. Biased expression in Liver (RPKM 79.4) and Heart (RPKM 6.).

Summary

Enables several functions, including adenyl ribonucleotide binding activity; glucose binding activity; and Hexokinase activity. Involved in several processes, including cellular chemical homeostasis; cellular response to hormone stimulus; and hexose metabolic process. Located in several cellular components, including basal cortex; nucleoplasm; and secretory granule. Colocalizes with actin filament. Used to study fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (Glucokinase). [provided by Alliance of Genome Resources, Apr 2022]

Gck Products(3)

mRNA Protein Name
NM_001270849.1 NP_001257778.1 hexokinase-4 isoform 1
NM_001270850.1 NP_001257779.1 hexokinase-4 isoform 3
NM_012565.2 NP_036697.1 hexokinase-4 isoform 2

Gck Protein Structure

Hexokinase_1

Hexokinase_1: pfam00349 (99 - 247)

Hexokinase_2

Hexokinase_2: pfam03727 (253 - 487)

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  • 498 a.a.
Protein Preferred Names Protein Names

hexokinase-4

HK IV

HK4

hexokinase type IV

hexokinase-D

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147141 HS-276 Inhibitor 98.59% Unkown
HY-15489 Scriptaid 98.59% Unkown
HY-10943 GNF-7 Inhibitor 98.08% Unkown
HY-123714 TL4-12 99.82% Unkown
HY-RS05329 GCK Human Pre-designed siRNA Set A / Unkown
HY-RS05330 Gck Mouse Pre-designed siRNA Set A / Unkown
HY-RS05331 Gck Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gck NCBI NCBI:2645