2. Gene
  3. Il1b - interleukin 1 beta Gene

Il1b - interleukin 1 beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as IL-1F2

Gene ID: 24494 | Gene type: protein coding

About Il1b

Primary_assembly 3: 116,577,010-116,583,415 reverse strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 233 orthologues, 6 paralogues and is associated with 280 phenotypes. Biased expression in Spleen (RPKM 194.1), Lung (RPKM 63.3) and 6 other tissues.

Summary

Enables cytokine activity. Involved in several processes, including positive regulation of intracellular signal transduction; regulation of gene expression; and regulation of neurogenesis. Located in extracellular space. Used to study several diseases, including artery disease (multiple); brain disease (multiple); glomerulonephritis (multiple); interstitial lung disease (multiple); and kidney failure (multiple). Biomarker of several diseases, including artery disease (multiple); auditory system disease (multiple); brain disease (multiple); kidney failure (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); eye disease (multiple); gastrointestinal system Cancer (multiple); and lung disease (multiple). Orthologous to human IL1B (interleukin 1 beta). [provided by Alliance of Genome Resources, Apr 2022]

Il1b Products(1)

mRNA Protein Name
NM_031512.2 NP_113700.2 interleukin-1 beta

Il1b Protein Structure

IL1_propep

IL1_propep: pfam02394 (0 - 101)

IL1

IL1: smart00125 (118 - 263)

  • 0
  • 100
  • 200
  • 268 a.a.
Protein Preferred Names Protein Names

interleukin-1 beta

IL-1 beta

Recombinant Il1b Proteins

Cat. No. Product Name Accession Purity
HY-P7097 IL-1 beta Protein, Rat Q63264 (V117-S268) ≥95%
HY-P7097A IL-1 beta Protein, Rat (His) Q5BKB0 (V117-S268) ≥95%
HY-P73900 IL-1 beta Protein, Rat (268a.a, His) Q63264 (M1-S268) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-141852 STAMBP-IN-1 Inhibitor 98.37% Unkown
HY-111662 Fc 11a-2 Inhibitor / Unkown
HY-147105 LRH-1 modulator-1 Modulator / Unkown
HY-162168 Anti-inflammatory agent 71 / Unkown
HY-P1117 MMK1 / Unkown
HY-P1117A MMK1 TFA / Unkown
HY-RS06716 IL1B Human Pre-designed siRNA Set A / Unkown
HY-RS06717 Il1b Mouse Pre-designed siRNA Set A / Unkown
HY-RS06718 Il1b Rat Pre-designed siRNA Set A / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99139 Anti-Mouse IL-1b Antibody (B122) Inhibitor 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il1b NCBI NCBI:3553
Canis familiaris Il1b NCBI NCBI:403974
Felis catus Il1b NCBI NCBI:768274
Macaca fascicularis Il1b NCBI NCBI:102119749
Mus musculus Il1b NCBI NCBI:16176
Susscrofa domestica Il1b NCBI
Leporidae Il1b NCBI
Macaca mulatta Il1b NCBI NCBI:704701