Il1b - interleukin 1 beta Gene

Also Known as IL-1F2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24494

About Il1b

Primary_assembly 3: 116,577,010-116,583,415 reverse strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 233 orthologues, 6 paralogues and is associated with 280 phenotypes. Biased expression in Spleen (RPKM 194.1), Lung (RPKM 63.3) and 6 other tissues.

Summary

Enables cytokine activity. Involved in several processes, including positive regulation of intracellular signal transduction; regulation of gene expression; and regulation of neurogenesis. Located in extracellular space. Used to study several diseases, including artery disease (multiple); brain disease (multiple); glomerulonephritis (multiple); interstitial lung disease (multiple); and kidney failure (multiple). Biomarker of several diseases, including artery disease (multiple); auditory system disease (multiple); brain disease (multiple); kidney failure (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); eye disease (multiple); gastrointestinal system Cancer (multiple); and lung disease (multiple). Orthologous to human IL1B (interleukin 1 beta). [provided by Alliance of Genome Resources, Apr 2022]

Il1b Products (1)

mRNA Protein Name
NM_031512.2 NP_113700.2 interleukin-1 beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
22279542 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to antibiotic IEP
IEP: Inferred from expression pattern
23200736 RGD
involved in cellular response to fatty acid IEP
IEP: Inferred from expression pattern
23086551 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
23053967 RGD
involved in cellular response to lipid IEP
IEP: Inferred from expression pattern
22964727 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
23200736 RGD
involved in chronic inflammatory response to antigenic stimulus IEP
IEP: Inferred from expression pattern
15050649 RGD
involved in fever generation IEP
IEP: Inferred from expression pattern
16455768 RGD
involved in learning or memory IEP
IEP: Inferred from expression pattern
17650650 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
15050649 RGD
involved in negative regulation of branching morphogenesis of a nerve IDA
IDA: Inferred from direct assay
22270046 RGD
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
23168994 RGD
involved in negative regulation of glutamate secretion IMP
IMP: Inferred from mutant phenotype
12667655 RGD
involved in negative regulation of neural precursor cell proliferation IDA
IDA: Inferred from direct assay
22270046 RGD
involved in negative regulation of neurogenesis IDA
IDA: Inferred from direct assay
22270046 RGD
involved in negative regulation of neuron differentiation IDA
IDA: Inferred from direct assay
22270046 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
23219998 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
15671867 RGD
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
15671867 RGD
involved in positive regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
12667655 RGD
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
22270046 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16038625 RGD
involved in positive regulation of astrocyte differentiation IDA
IDA: Inferred from direct assay
22270046 RGD
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
15671867 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
12213318 RGD
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
22279542 RGD
involved in positive regulation of glial cell differentiation IDA
IDA: Inferred from direct assay
23168994 RGD
involved in positive regulation of immature T cell proliferation in thymus IDA
IDA: Inferred from direct assay
8590311 RGD
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
15671867 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
23262920 RGD
involved in positive regulation of neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
1519663 RGD
involved in positive regulation of stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
15671867 RGD
involved in positive regulation of stress-activated MAPK cascade IMP
IMP: Inferred from mutant phenotype
12629164 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19717791 RGD
involved in regulation of neurogenesis IGI
IGI: Inferred from genetic interaction
20018408 RGD
involved in response to L-ascorbic acid IEP
IEP: Inferred from expression pattern
18983910 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
21898269 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
17678971 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
23206318 RGD
involved in response to gamma radiation IEP
IEP: Inferred from expression pattern
16524844 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
17621647 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
19342292 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
25641164 RGD
involved in response to isolation stress IEP
IEP: Inferred from expression pattern
33411841 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17201737 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
17437639 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17071120 RGD
involved in response to ozone IEP
IEP: Inferred from expression pattern
17901407 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
22956308 RGD
involved in response to stilbenoid IEP
IEP: Inferred from expression pattern
23211629 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
17621647 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17071120 RGD
involved in social behavior IMP
IMP: Inferred from mutant phenotype
9831177 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
17201737 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il1b Protein Structure

IL1_propep

IL1_propep: pfam02394 (0 - 101)

IL1

IL1: smart00125 (118 - 263)

  • 0
  • 100
  • 200
  • 268 a.a.
Protein Preferred Names Protein Names

interleukin-1 beta

  • IL-1 beta

Recombinant Il1b Proteins

Cat. No. Product Name Accession Purity
HY-P7097 IL-1 beta Protein, Rat Q63264 (V117-S268) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7097A IL-1 beta Protein, Rat (His) Q5BKB0 (V117-S268) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73900 IL-1 beta Protein, Rat (268a.a, His) Q63264 (M1-S268) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1117 MMK1 99.71% Unkown
HY-141852 STAMBP-IN-1 Inhibitor 98.73% Unkown
HY-111662 Fc 11a-2 Inhibitor 99.75% Unkown
HY-147105A (+)-LRH-1 agonist-2 Modulator 99.38% Unkown
HY-RS06716 IL1B Human Pre-designed siRNA Set A / Unkown
HY-162168 Anti-inflammatory agent 71 Inhibitor / Unkown
HY-179407 LT-104A Inhibitor / Unkown
HY-P1117A MMK1 TFA / Unkown
HY-RS06717 Il1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06718 Il1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174627 Human IL1B mRNA / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99139 Anti-Mouse IL-1b Antibody (B122) 99% Unkown
HY-P990563 CDP-484 99.34% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il1b NCBI NCBI:3553