NPY - Npy neuropeptide Y Gene

Also Known as NPY02; RATNPY; RATNPY02

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24604

Summary

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. Studies in the rat model of depression (Flinders Sensitive Line) show that this gene is downregulated in the hippocampus and the prefrontal cortex compared to the control ((Flinders Resistant Line). Alternatively spliced transcript variants of this gene have been described, but the function of all the variants is not known. [provided by RefSeq, Jul 2012]

NPY Products (1)

mRNA Protein Name
NM_012614.2 NP_036746.1 pro-neuropeptide Y preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables neuropeptide Y receptor binding IMP
IMP: Inferred from mutant phenotype
12446577 RGD
Biological Process GO Annotation Evidence References Source
involved in adult feeding behavior IDA
IDA: Inferred from direct assay
9590691 RGD
involved in chemical synaptic transmission IDA
IDA: Inferred from direct assay
12482942 RGD
involved in monocyte activation IDA
IDA: Inferred from direct assay
15342191 RGD
involved in negative regulation of acute inflammatory response to antigenic stimulus IDA
IDA: Inferred from direct assay
18805447 RGD
involved in negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
15699473 RGD
involved in neuropeptide signaling pathway IMP
IMP: Inferred from mutant phenotype
15703301 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
21595512 RGD
involved in positive regulation of appetite IDA
IDA: Inferred from direct assay
9590691 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
21595512 RGD
involved in positive regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
15342191 RGD
involved in positive regulation of dopamine metabolic process IDA
IDA: Inferred from direct assay
19579268 RGD
involved in positive regulation of eating behavior IDA
IDA: Inferred from direct assay
21303672 RGD
involved in positive regulation of nitric oxide metabolic process IDA
IDA: Inferred from direct assay
18805447 RGD
involved in regulation of nerve growth factor production IDA
IDA: Inferred from direct assay
22860197 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration EXP
EXP: Inferred from Experiment
16026936 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
16026936 RGD
involved in regulation of synaptic vesicle exocytosis EXP
EXP: Inferred from Experiment
16026936 RGD
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
16026936 RGD
involved in short-day photoperiodism IEP
IEP: Inferred from expression pattern
19490367 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
9590691 RGD
is active in neuronal dense core vesicle IDA
IDA: Inferred from direct assay
29775703 RGD
located in neuronal dense core vesicle IDA
IDA: Inferred from direct assay
29166604 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
21344400 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17353067 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
21344400 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pro-neuropeptide Y

  • pro-neuropeptide Y-like

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-14423 Velneperit Antagonist 98.25% Phase 2
HY-P10026 Nisotirostide Agonist 99.45% Phase 2

Pre-clinical Phase

Bioactive Molecules (75)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0221 PACAP (1-38), human, ovine, rat Inducer 99.99% Unkown
HY-107725 BIBO3304 Antagonist 99.96% Unkown
HY-101986 BIIE-0246 Antagonist 99.10% Unkown
HY-107726 BIBP3226 TFA Antagonist 99.92% Unkown
HY-P10000 Peptide YY (PYY) (3-36), Human Agonist 98.00% Unkown
HY-116797 MS15203 99.40% Unkown
HY-P0208 [Leu31,Pro34]-Neuropeptide Y (porcine) Agonist 99.66% Unkown
HY-P1845 PACAP-38 (31-38), human, mouse, rat 98.93% Unkown
HY-107565 2-Pyridylethylamine hydrochloride Agonist 98.61% Unkown
HY-120619 BMS-193885 Antagonist 99.91% Unkown
HY-107733 NTNCB hydrochloride Antagonist 98.36% Unkown
HY-P0199 Pancreatic Polypeptide, human Agonist 99.39% Unkown
HY-P1845A PACAP-38 (31-38), human, mouse, rat TFA 99.30% Unkown
HY-107734 L 152804 Antagonist 99.89% Unkown
HY-107735 CYM 9484 Antagonist 98.68% Unkown
HY-P1011 Neuropeptide Y (13-36), porcine Agonist 99.31% Unkown
HY-107730 NPY5RA-972 Antagonist 98.99% Unkown
HY-P1322 [D-Trp34]-Neuropeptide Y Agonist 99.70% Unkown
HY-P4060A Pancreatic polypeptide TFA Agonist 99.47% Unkown
HY-P1324 [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide Agonist 99.15% Unkown
HY-107726A BIBP3226 Antagonist 98.78% Unkown
HY-P3678 Neuropeptide Y (18-36) (porcine) Antagonist 98.76% Unkown
HY-P4087B Cys(Npys)-(Arg)9 acetate 95.15% Unkown
HY-W141779 Boc-Cys(Npys)-OH 98.0% Unkown
HY-101986A BIIE-0246 hydrochloride Antagonist 99.33% Unkown
HY-107728 S 25585 Antagonist 99.13% Unkown
HY-148179 Neuropeptide Y5 receptor ligand-1 Antagonist 98.0% Unkown
HY-P10148 N-Acetyl [Leu28, Leu31] neuropeptide Y (24–36) Agonist 99.63% Unkown
HY-P11291A NNC0165-1273 TFA Agonist 97.79% Unkown
HY-RS09510 NPY Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09512 Npy1r Mouse Pre-designed siRNA Set A / Unkown
HY-156922 NPY-5 receptor antagonist-1 Antagonist 99.86% Unkown
HY-RS09511 NPY1R Human Pre-designed siRNA Set A / Unkown
HY-101986C BIIE-0246 dihydrochloride Antagonist / Unkown
HY-103247 EMD 66684 Antagonist / Unkown
HY-107723A CGP71683 Antagonist / Unkown
HY-107725A BIBO3304 diTFA Inhibitor / Unkown
HY-110107 GW438014A Antagonist 99.98% Unkown
HY-118198 NPY Y2 antagonist 1 Antagonist 98.60% Unkown
HY-120096 BIBO3304 free base Antagonist / Unkown
HY-180406 NPY Y2 antagonist 2 Modulator / Unkown
HY-P0198B [D-Arg25]-Neuropeptide Y (human) Agonist / Unkown
HY-P0221A PACAP (1-38), human, ovine, rat TFA Inducer / Unkown
HY-P10291 [Pro34]Neuropeptide Y, porcine Agonist / Unkown
HY-P10545 [D-His26]-Neuropeptide Y, human, rat Agonist / Unkown
HY-P11291 NNC0165-1273 Agonist / Unkown
HY-P11291B NNC0165-1273 acetate Agonist 99.78% Unkown
HY-P11411 [D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat Agonist / Unkown
HY-P1322A [D-Trp34]-Neuropeptide Y TFA Agonist / Unkown
HY-P1324A [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA Agonist / Unkown
HY-P1327 BVD 10 Antagonist / Unkown
HY-P1532 Pancreatic Polypeptide, rat Agonist / Unkown
HY-P1537 Pancreatic Polypeptide, bovine Agonist / Unkown
HY-P3676 Neuropeptide Y (3-36) (porcine) Agonist / Unkown
HY-P3679 Neuropeptide Y (1-24) (human) Activator / Unkown
HY-P4087 Cys(Npys)-(Arg)9 / Unkown
HY-P4101 Cys(Npys)-TAT (47-57) / Unkown
HY-P4103 Cys(Npys)-TAT (47-57), FAM-labeled / Unkown
HY-P4123 TAT (47-57) GGG-Cys(Npys) Inhibitor / Unkown
HY-P5757 (D-Trp32)-Neuropeptide Y (porcine) Agonist / Unkown
HY-RS09513 Npy1r Rat Pre-designed siRNA Set A / Unkown
HY-RS09514 NPY2R Human Pre-designed siRNA Set A / Unkown
HY-RS09515 Npy2r Mouse Pre-designed siRNA Set A / Unkown
HY-RS09516 NPY2R Rat Pre-designed siRNA Set A / Unkown
HY-RS09517 NPY4R Human Pre-designed siRNA Set A / Unkown
HY-RS09518 Npy4r Mouse Pre-designed siRNA Set A / Unkown
HY-RS09519 Npy4r Rat Pre-designed siRNA Set A / Unkown
HY-RS09520 NPY5R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09521 Npy5r Mouse Pre-designed siRNA Set A / Unkown
HY-RS09522 Npy5r Rat Pre-designed siRNA Set A / Unkown
HY-W782997 SCH 430765 Antagonist / Unkown
HY-110107A GW438014A free base Antagonist / Unkown
HY-RS16546 Npy Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22978 Npy Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W336281 Fmoc-Cys(npys)-OH / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens NPY NCBI NCBI:4852