NPY - neuropeptide Y Gene

Also Known as PYY4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4852

About NPY

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:24,284,190-24,291,862 (from NCBI)

This gene has 3 transcripts (splice variants), 258 orthologues and 2 paralogues. Biased expression in prostate (RPKM 182.5), brain (RPKM 56.2) and 1 other tissue.

Summary

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated Cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

NPY Products (1)

mRNA	Protein	Name
NM_000905.4	NP_000896.1	pro-neuropeptide Y preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	18603306	GOA
involved in antifungal humoral response	IDA IDA: Inferred from direct assay	18603306	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	18603306	GOA
involved in central nervous system neuron development	IEP IEP: Inferred from expression pattern	20846339	GOA
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	9067840	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	18603306	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	18603306	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	18603306	GOA
involved in neuron projection development	IEP IEP: Inferred from expression pattern	20846339	GOA
involved in response to yeast	IDA IDA: Inferred from direct assay	18603306	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPY Protein Structure

Hormone_3

0
97 a.a.

Protein Preferred Names	Protein Names
pro-neuropeptide Y	prepro-neuropeptide Y

NPY Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NPY	P01303	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NPY Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71063	NPY Protein, Human (HEK293, His)	P01303 (Y29-W97)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Eating Disorder	Eating Disorders Feeding And Eating Disorders
Anorexia Nervosa	Anorexia Nervosa, Susceptibility To ANON Anorexia Nervosa, Susceptibility To, 1 An Anorexia Nervosa 1 An - [Anorexia Nervosa]
Normal Pressure Hydrocephalus	Low Pressure Hydrocephalus Hydrocephalus Normal Pressure Hydrocephalus, Normal Pressure Normal Pressure Hydrocephalus Nos Nph - [Normal Pressure Hydrocephalus] Normal Pressure Hydrocephaly
Bulimia Nervosa	Bulimia Bulimia Nervosa, Susceptibility To Binge Eating Disorder BULN Bn Hyperorexia Nervosa Bulimia Nervosa 2 BULN2 Susceptibility To Bulimia Nervosa Bulimia Nervosa, Susceptibility To, Type 2 Bn - [Bulimia Nervosa] Bulimia Nos Bulimic Bingeing Binge Overeating Bouts Of Overeating Episodes Of Overeating
Reflex Sympathetic Dystrophy	Algodystrophy Reflex Sympathetic Dystrophy Syndrome Complex Regional Pain Syndrome Type 1 Complex Regional Pain Syndromes Algodystrophic Syndrome
Status Epilepticus	Grand Mal Status Epilepticus Grand Mal Status Gcse Generalized Convulsive Status Epilepticus Se Epilepsy With Status Epilepticus
Temporal Lobe Epilepsy	Epilepsy, Temporal Lobe Epilepsy Temporal Lobe
Fibromyalgia	Diffuse Myofascial Pain Syndrome Fibromyalgia Syndrome Fibromyalgia-Fibromyositis Syndrome Fibromyositis Fibrositis Fms Myofascial Pain Syndrome Myofascial Pain Syndromes
Mood Disorder	Mood Disorders Episodic Mood Disorder
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Autonomic Neuropathy	Diabetic Autonomic Neuropathy
Carcinoid Syndrome	Carcinoid Tumor Malignant Carcinoid Syndrome Carcinoid Tumor Syndrome Carcinoid Tumors Carcinoid Tumor No Icd-O Subtype Argentaffinoma Syndrome
Hyperinsulinism	Hyperinsulinemia
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Empty Sella Syndrome	Empty Sella Turcica Empty Sella
Subependymal Giant Cell Astrocytoma	Sega Astrocytoma Subependymal Giant Cell Subependymal Giant-Cell Astrocytoma
Leptin Deficiency Or Dysfunction	Morbid Obesity Obesity Due To Congenital Leptin Deficiency LEPD Congenital Leptin Deficiency Obesity, Morbid Obesity, Morbid, Due To Leptin Deficiency Severe Obesity Obesity, Morbid, Nonsyndromic 1 Leptin Deficiency Obesity, Severe, Due To Leptin Deficiency Leptin Morbid Obesity Due To Leptin Deficiency Obesity Morbid Leptin Dysfunction
Von Hippel-Lindau Syndrome	Von Hippel-Lindau Disease Vhl Vhl Syndrome VHLS Von Hippel-Lindau Syndrome, Modifier Of Hippel Lindau Syndrome Angiomatosis Retinae Cerebelloretinal Angiomatosis, Familial Hippel-Lindau Disease Familial Cerebelloretinal Angiomatosis Lindau Disease VHLD
Rhinitis	Runny Nose
Prader-Willi Syndrome	Prader-Labhart-Willi Syndrome PWS Willi-Prader Syndrome Prader-Willi Syndrome Due To Translocation Prader-Willi Syndrome Due To Imprinting Mutation Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15 Prader Willi Syndrome Upd(15)Mat
Drug Dependence
Post-Traumatic Stress Disorder	PTSD Traumatic Neurosis Post Traumatic Stress Disorder Stress Disorders, Post-Traumatic Posttraumatic Stress Disorder Ptsd - [Post Traumatic Stress Disorder] Trauma-Related Disorders
Pertussis	Whooping Cough Bordetella Infections Bordetella Infection Bordetella Pertussis Infection Wc - Whooping Cough Whooping Cough Due To Unspecified Organism Bordetellosis Tussis Convulsiva Whooping Cough, Unspecified Organism Wc - [Whooping Cough] Whooping Cough Due To B. Parapertussis Infection Due To Bordetella Parapertussis
Congestive Heart Failure	Congestive Heart Disease Heart Failure Cardiac Failure Congestive Chf Weak Heart Heart Failure Congestive Ccf - [Congestive Cardiac Failure] Chf - [Congestive Heart Failure] Congestive Cardiac Diseases Congested Heart Failure Congestive Cardiac Failure Cardiac Anasarca Cardiac Oedema Cardiac Stasis Cardiovascular Oedema Cardiac Hydrops Congestive Failure Heart Congestion Heart Fluid Oedematous Heart
Ganglioneuroblastoma
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Constipation
Rabies	Lyssa Hydrophobia St Hubert Disease
Amenorrhea	Absence Of Menstruation Amenia
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Impotence	Erectile Dysfunction Sexual Impotence Erectile Dysfunction Adverse Event
Achalasia	Cardiospasm Achalasia Of Cardia Esophageal Achalasia Hypertensive Lower Esophageal Sphincter Idiopathic Achalasia Achalasia Cardia Idiopathic Achalasia Of Esophagus Primary Achalasia Achalasia Of Esophagus Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter Aperistalsis Of The Oesophagus Achalasia Of Oesophagus Oesophageal Achalasia Achalasia Nos Cardia Spasm Cardia Achalasia Oesophageal Cardiospasm Oesophagus Achalasia Reflex Cardiospasm
Liver Cirrhosis	Cirrhosis Cirrhosis Of Liver CIRRH Cryptogenic Cirrhosis Cirrhosis, Cryptogenic Cirrhosis Nos
Erythroleukemia
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Macular Degeneration, Age-Related, 14	Age Related Macular Degeneration 14 ARMD14 Macular Degeneration, Age-Related, 14, Reduced Risk Of Macular Degeneration, Age-Related, Type 14
Hypoglycemia	Hypoglycaemia Low Blood Sugar Hypoglycaemia Nos Spontaneous Hypoglycaemia Nondiabetic Hypoglycaemia Hypoglycaemic Disorder Nos Hypoglycaemic Syndrome
Sleep Apnea	Sleep Apnea Syndromes
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Hepatorenal Syndrome	Hepato-Renal Syndrome Hepatorenal Failure Hrf - [Hepatorenal Failure] Hepatorenal Degeneration Hepatic Renal Syndrome Hepatic Renal Failure Renal Hepatic Failure Urohepatic Syndrome
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Headache	Headache Disorder
Pelvic Organ Prolapse	Rectal Prolapse Pelvic Organ Prolapse, Susceptibility To, 1 Pelvic Organ Prolapse, Susceptibility To Prolapse Of Vagina And Rectum Vaginal Prolapse Pelvic Organ Prolapse 1 Procidentia, Rectum Prolapse Of Rectal Mucosa Procidentia Of Rectum Rectal Mucosa Prolapse Rectum Prolapse Procidentia Rectum Rp - [Rectal Prolapse] Male Proctocele Male Rectocele Proctoptosis Female Genital Prolapse Female Prolapse Incompetence Of Pelvic Fundus Relaxation Of Perineum Deficiency Of Perineum
Diabetes Mellitus	Diabetes
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Acute Endometritis
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1	Vitiligo VAMAS1 Slev1 Vtlg Systemic Lupus Erythematosus, Vitiligo-Related Vitiligo-Associated Multiple Autoimmune Disease 1 Systemic Lupus Erythematosus Vitiligo-Related
Prediabetes Syndrome	Prediabetes Impaired Glucose Tolerance Prediabetic State IGT Igt - [Impaired Glucose Tolerance] Impaired Glucose Tolerance With Unspecified Complication Impaired Glucose Tolerance Without Complication Abnormal Glucose Tolerance
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Nutritional Deficiency Disease	Malnutrition Nutritional Disorder Nutritional Deficiency Nutrition Deficiency Diseases Carbamoyl-Phosphate Synthase I Deficiency Disease Nutrition Disorders
Perianal Hematoma	External Thrombosed Haemorrhoids Thrombosed External Hemorrhoids
Sex Cord-Gonadal Stromal Tumor	Sex Cord-Gonadal Stromal Tumour Sex Cord Stromal Tumour Sex Cord-Stromal Neoplasm Specialized Gonadal Neoplasm Specialized Gonadal Tumor Specialized Gonadal Tumour Sex Cord-Gonadal Stromal Tumors Sex Cord-Stromal Tumor Malignant Testicular Sex Cord-Stromal Tumor Sex Cord Stromal Tumor Of Testis
Overnutrition
Acquired Metabolic Disease
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Substance Dependence
Specific Developmental Disorder
Focal Epilepsy	Partial Epilepsy Epilepsies, Partial Localisation-Related Epilepsy
Articulation Disorder	Phonological Disorder Articulation Disorders Articulation Impairment Speech Sound Disorders
Autonomic Nervous System Disease	Autonomic Nervous System Dysfunction Autonomic Nervous System Disorders Autonomic Nervous System Disorder Autonomic Nervous System Diseases Abnormality Of The Autonomic Nervous System
Esophageal Atresia	Tracheoesophageal Fistula Congenital Atresia Of Esophagus Congenital Imperforate Esophagus Imperforate Esophagus Oesophageal Atresia Te Fistula Tef Tracheoesophageal Fistula With Or Without Esophageal Atresia
Orthostatic Intolerance	Mitral Valve Prolapse Neurocirculatory Asthenia Mitral Valve Prolapse Syndrome Irritable Heart Systolic Click-Murmur Syndrome Soldiers Heart Cardiovascular Malfunction Arising From Mental Factors Cardiovascular Neurosis Da Costa'S Syndrome Krishaber'S Disease Barlow'S Syndrome Floppy Mitral Valve Mitral Leaflet Syndrome Myxomatous Mitral Valve Prolapse Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency Orthostatic Intolerance Due To Net Deficiency Pots Due To Net Deficiency OI Intolerance, Orthostatic Mitral Valve Prolapse, Familial, X-Linked Ballooning Mitral Valve Barlow Syndrome Flail Mitral Leaflet Myxomatous Mitral Valve Mitral Valve Prolapse-Click Syndrome Prolapsing Mitral Valve Leaflet Syndrome Billowing Mitral Valve Leaflet Posterior Mitral Leaflet Deformity Ballooning Posterior Leaflet Syndrome Blue Valve Syndrome Floppy Mitral Valve Syndrome Mitral Valvular Prolapse Systolic Click Syndrome
Substance Abuse	Substance-Related Disorders Substance Abuse Problem
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Sleep Disorder	Sleep Disorders Non-Organic Sleep Disorder
Alcohol Use Disorder	Alcohol Abuse Alcoholism Ethanol Abuse Alcohol Addiction Alcohol Dependence Alcoholic Intoxication, Chronic Alcohol-Related Disorders
Stuttering	Stammering Familial Persistent Stuttering Stuttering, Familial Persistent 1
Mental Depression	Depression Depressive Disorder
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Glucocorticoid Deficiency 1	Acth Resistance Glucocorticoid Deficiency, Due To Acth Unresponsiveness GCCD1 Familial Glucocorticoid Deficiency 1 Fgd1 Adrenal Unresponsiveness To Acth Hereditary Unresponsiveness To Adrenocorticotropic Hormone Isolated Glucocorticoid Deficiency
Disease Of Mental Health	Mental Health Mental Disorders
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
West Syndrome	Infantile Spasms Infantile Spasms Syndrome Infantile Spasm X-Linked Infantile Spasm Syndrome X-Linked Infantile Spasms Epileptic Encephalopathy, Early Infantile, 1 Is Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg West'S Syndrome Spasms, Infantile Is -[Infantile Spasm] Salaam Spasm Salaam Tic
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14423	Velneperit	Antagonist	98.25%	Phase 2
HY-P10026	Nisotirostide	Agonist	99.45%	Phase 2

Pre-clinical Phase

Bioactive Molecules (75)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0221	PACAP (1-38), human, ovine, rat	Inducer	99.99%	Unkown
HY-107725	BIBO3304	Antagonist	99.96%	Unkown
HY-101986	BIIE-0246	Antagonist	99.10%	Unkown
HY-107726	BIBP3226 TFA	Antagonist	99.92%	Unkown
HY-P10000	Peptide YY (PYY) (3-36), Human	Agonist	98.00%	Unkown
HY-116797	MS15203		99.40%	Unkown
HY-P0208	[Leu31,Pro34]-Neuropeptide Y (porcine)	Agonist	99.66%	Unkown
HY-P1845	PACAP-38 (31-38), human, mouse, rat		98.93%	Unkown
HY-107565	2-Pyridylethylamine hydrochloride	Agonist	98.61%	Unkown
HY-120619	BMS-193885	Antagonist	99.91%	Unkown
HY-107733	NTNCB hydrochloride	Antagonist	98.36%	Unkown
HY-P0199	Pancreatic Polypeptide, human	Agonist	99.39%	Unkown
HY-P1845A	PACAP-38 (31-38), human, mouse, rat TFA		99.30%	Unkown
HY-107734	L 152804	Antagonist	99.89%	Unkown
HY-107735	CYM 9484	Antagonist	98.68%	Unkown
HY-P1011	Neuropeptide Y (13-36), porcine	Agonist	99.31%	Unkown
HY-107730	NPY5RA-972	Antagonist	98.99%	Unkown
HY-P1322	[D-Trp34]-Neuropeptide Y	Agonist	99.70%	Unkown
HY-P4060A	Pancreatic polypeptide TFA	Agonist	99.47%	Unkown
HY-P1324	[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide	Agonist	99.15%	Unkown
HY-107726A	BIBP3226	Antagonist	98.78%	Unkown
HY-P3678	Neuropeptide Y (18-36) (porcine)	Antagonist	98.76%	Unkown
HY-P4087B	Cys(Npys)-(Arg)9 acetate		95.15%	Unkown
HY-W141779	Boc-Cys(Npys)-OH		98.0%	Unkown
HY-101986A	BIIE-0246 hydrochloride	Antagonist	99.33%	Unkown
HY-107728	S 25585	Antagonist	99.13%	Unkown
HY-148179	Neuropeptide Y5 receptor ligand-1	Antagonist	98.0%	Unkown
HY-P10148	N-Acetyl [Leu28, Leu31] neuropeptide Y (24–36)	Agonist	99.63%	Unkown
HY-P11291A	NNC0165-1273 TFA	Agonist	97.79%	Unkown
HY-RS09510	NPY Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09512	Npy1r Mouse Pre-designed siRNA Set A		/	Unkown
HY-156922	NPY-5 receptor antagonist-1	Antagonist	99.86%	Unkown
HY-RS09511	NPY1R Human Pre-designed siRNA Set A		/	Unkown
HY-101986C	BIIE-0246 dihydrochloride	Antagonist	/	Unkown
HY-103247	EMD 66684	Antagonist	/	Unkown
HY-107723A	CGP71683	Antagonist	/	Unkown
HY-107725A	BIBO3304 diTFA	Inhibitor	/	Unkown
HY-110107	GW438014A	Antagonist	99.98%	Unkown
HY-118198	NPY Y2 antagonist 1	Antagonist	98.60%	Unkown
HY-120096	BIBO3304 free base	Antagonist	/	Unkown
HY-180406	NPY Y2 antagonist 2	Modulator	/	Unkown
HY-P0198B	[D-Arg25]-Neuropeptide Y (human)	Agonist	/	Unkown
HY-P0221A	PACAP (1-38), human, ovine, rat TFA	Inducer	/	Unkown
HY-P10291	[Pro34]Neuropeptide Y, porcine	Agonist	/	Unkown
HY-P10545	[D-His26]-Neuropeptide Y, human, rat	Agonist	/	Unkown
HY-P11291	NNC0165-1273	Agonist	/	Unkown
HY-P11291B	NNC0165-1273 acetate	Agonist	99.78%	Unkown
HY-P11411	[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat	Agonist	/	Unkown
HY-P1322A	[D-Trp34]-Neuropeptide Y TFA	Agonist	/	Unkown
HY-P1324A	[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA	Agonist	/	Unkown
HY-P1327	BVD 10	Antagonist	/	Unkown
HY-P1532	Pancreatic Polypeptide, rat	Agonist	/	Unkown
HY-P1537	Pancreatic Polypeptide, bovine	Agonist	/	Unkown
HY-P3676	Neuropeptide Y (3-36) (porcine)	Agonist	/	Unkown
HY-P3679	Neuropeptide Y (1-24) (human)	Activator	/	Unkown
HY-P4087	Cys(Npys)-(Arg)9		/	Unkown
HY-P4101	Cys(Npys)-TAT (47-57)		/	Unkown
HY-P4103	Cys(Npys)-TAT (47-57), FAM-labeled		/	Unkown
HY-P4123	TAT (47-57) GGG-Cys(Npys)	Inhibitor	/	Unkown
HY-P5757	(D-Trp32)-Neuropeptide Y (porcine)	Agonist	/	Unkown
HY-RS09513	Npy1r Rat Pre-designed siRNA Set A		/	Unkown
HY-RS09514	NPY2R Human Pre-designed siRNA Set A		/	Unkown
HY-RS09515	Npy2r Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS09516	NPY2R Rat Pre-designed siRNA Set A		/	Unkown
HY-RS09517	NPY4R Human Pre-designed siRNA Set A		/	Unkown
HY-RS09518	Npy4r Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS09519	Npy4r Rat Pre-designed siRNA Set A		/	Unkown
HY-RS09520	NPY5R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09521	Npy5r Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS09522	Npy5r Rat Pre-designed siRNA Set A		/	Unkown
HY-W782997	SCH 430765	Antagonist	/	Unkown
HY-110107A	GW438014A free base	Antagonist	/	Unkown
HY-RS16546	Npy Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22978	Npy Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W336281	Fmoc-Cys(npys)-OH		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NPY	MGD	MGI:97374
Bos taurus	NPY	VGNC	VGNC:32222
Macaca mulatta	NPY	VGNC	VGNC:75393
Felis catus	NPY	VGNC	VGNC:68538
Canis familiaris	NPY	VGNC	VGNC:43936
Rattus norvegicus	NPY	RGD	RGD:3197
Others	NPY	NCBI