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Cat. No.: HY-107723A

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CGP71683

CGP 71683 Free base serves as a powerful and highly selective non-peptide antagonist targeting the NPY Y(5) receptor, making it a valuable tool in obesity research.

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CAS No.: 192321-23-6
화학식: C₂₆H₂₉N₅O₂S
분자량:475.61

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (241 KB)

CGP71683 Chemical Structure

CAS No.: 192321-23-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- Cellular Effect
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Biological Activity

제품 설명

CGP 71683 Free base serves as a powerful and highly selective non-peptide antagonist targeting the NPY Y(5) receptor, making it a valuable tool in obesity research.

All Neuropeptide Y Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
COS-1	IC₅₀	1.3 nM Compound: CGP-71683A (Trans)	Inhibitory activity against constitutively activated human Neuropeptide Y receptor Y5 transiently expressed in COS-1 cells using [125I]PYY Inhibitory activity against constitutively activated human Neuropeptide Y receptor Y5 transiently expressed in COS-1 cells using [125I]PYY	[PMID: 15863317]
COS-1	IC₅₀	97 nM Compound: CGP-71683A (Trans)	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912 Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	[PMID: 15863317]
HEK293	IC₅₀	3500 nM Compound: CGP-71683A (Trans)	Inhibitory activity against mutated constitutively activated human Melanin concentrating hormone receptor 1 (CA-MCH-R1) stably expressed in HEK293 cells using [125I](Phe13, Tyr19) MCH Inhibitory activity against mutated constitutively activated human Melanin concentrating hormone receptor 1 (CA-MCH-R1) stably expressed in HEK293 cells using [125I](Phe13, Tyr19) MCH	[PMID: 15863317]

Chemical Information

CAS No. 192321-23-6
분자량 475.61
화학식 C₂₆H₂₉N₅O₂S
SMILES

NC1=NC(NC[C@@H](CC2)CC[C@H]2CNS(=O)(C3=CC=CC4=CC=CC=C34)=O)=NC5=CC=CC=C51
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.