Reg1a - regenerating family member 1 alpha Gene

Also Known as Reg; RGPI; Reg1; Rgp1; LITHOST; RATRGPI; RATLITHOST

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24714

Summary

Enables growth factor activity; identical protein binding activity; and protein Phosphatase binding activity. Involved in several processes, including animal organ regeneration; cellular response to gastrin; and positive regulation of epithelial cell proliferation. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and zymogen granule. Part of protein-containing complex. Biomarker of colon Cancer and myocardial infarction. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to several human genes including REG1A (regenerating family member 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Reg1a Products (1)

mRNA Protein Name
NM_012641.2 NP_036773.1 lithostathine precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables growth factor activity IDA
IDA: Inferred from direct assay
10526060 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
11278730 RGD
enables phosphatase binding IPI
IPI: Inferred from physical interaction
18929742 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10662590 RGD
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
18929742 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
10753861 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to chemokine IEP
IEP: Inferred from expression pattern
11113082 RGD
involved in cellular response to gastrin IEP
IEP: Inferred from expression pattern
10348814 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
19284990 RGD
involved in midgut development IEP
IEP: Inferred from expression pattern
7720628 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18929742 RGD
involved in pancreas regeneration IEP
IEP: Inferred from expression pattern
1985964 RGD
involved in positive regulation of acinar cell proliferation IDA
IDA: Inferred from direct assay
9788538 RGD
involved in positive regulation of dendrite extension IMP
IMP: Inferred from mutant phenotype
22158612 RGD
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
18929742 RGD
involved in positive regulation of type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
24055447 RGD
involved in response to gastrin IEP
IEP: Inferred from expression pattern
9834276 RGD
involved in response to growth hormone-releasing hormone IEP
IEP: Inferred from expression pattern
7720628 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
24055447 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
1985964 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16874863 RGD
involved in response to water-immersion restraint stress IEP
IEP: Inferred from expression pattern
8698224 RGD
Cellular Component GO Annotation Evidence References Source
located in basal part of cell IDA
IDA: Inferred from direct assay
12764608 RGD
located in dendrite membrane IDA
IDA: Inferred from direct assay
22158612 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
1886885 RGD
located in growth cone IDA
IDA: Inferred from direct assay
22158612 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
22158612 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
22158612 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
11278730 RGD
located in zymogen granule IDA
IDA: Inferred from direct assay
12764608 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lithostathine

  • ICRF

  • PSP

  • PTP

  • islet cells regeneration factor

  • islet of Langerhans regenerating protein

  • pancreatic stone protein

  • pancreatic thread protein

  • regenerating islet-derived 1 alpha

  • regenerating islet-derived mouse homolog 1

  • regeneration protein, lithostat

Recombinant Reg1a Proteins

Cat. No. Product Name Accession Purity
HY-P77173 REG1A Protein, Rat (HEK293, Fc) P10758 (Q22-A165) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11818 REG1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24389 Reg1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Reg1a NCBI NCBI:5967