Hk1 - hexokinase 1 Gene

Also Known as HKI; HEXOKIN

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25058

Summary

Enables several functions, including ATP binding activity; glucose binding activity; and Hexokinase activity. Involved in several processes, including phosphorylation; response to ischemia; and response to ketamine. Located in caveola; cytosol; and mitochondrion. Part of protein-containing complex. Used to study obesity and urinary bladder Cancer. Biomarker of colorectal Cancer and pulmonary hypertension. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic Cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (Hexokinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hk1 Products (2)

mRNA Protein Name
NM_001393711.1 NP_001380640.1 hexokinase-1 isoform 1
NM_012734.2 NP_036866.2 hexokinase-1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
15562563 RGD
enables D-glucose binding IDA
IDA: Inferred from direct assay
9665168 RGD
enables fructokinase activity IDA
IDA: Inferred from direct assay
5871820 RGD
enables glucokinase activity IDA
IDA: Inferred from direct assay
5871820 RGD
enables hexokinase activity IDA
IDA: Inferred from direct assay
2457393 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
9665168 RGD
enables mannokinase activity IDA
IDA: Inferred from direct assay
13211595 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16419038 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
7531990 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
14561215 RGD
Biological Process GO Annotation Evidence References Source
involved in carbohydrate phosphorylation IDA
IDA: Inferred from direct assay
14561215 RGD
involved in fructose 6-phosphate metabolic process IDA
IDA: Inferred from direct assay
5871820 RGD
involved in glucose 6-phosphate metabolic process IDA
IDA: Inferred from direct assay
5871820 RGD
involved in glycolytic process IDA
IDA: Inferred from direct assay
4353083 RGD
involved in mannose metabolic process IDA
IDA: Inferred from direct assay
13211595 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15574336 RGD
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
7531990 RGD
involved in peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
7531990 RGD
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
7531990 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
2059200 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
2059200 RGD
involved in regulation of anion channel activity IDA
IDA: Inferred from direct assay
14561215 RGD
involved in response to brassinosteroid IEP
IEP: Inferred from expression pattern
20570616 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
29676955 RGD
involved in response to ischemia IDA
IDA: Inferred from direct assay
21410437 RGD
involved in response to ketamine IEP
IEP: Inferred from expression pattern
22605548 RGD
Cellular Component GO Annotation Evidence References Source
located in caveola IDA
IDA: Inferred from direct assay
16419038 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
2457393 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
9459579 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hexokinase-1

  • brain form hexokinase

  • hexokinase type I

  • hexokinase-A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18768 NCT-501 99.59% Unkown
HY-N6954 Garcinone C 99.51% Unkown
HY-P10412 A11 Inhibitor 98.49% Unkown
HY-N20662 (+)-Neoalbaconol / Unkown
HY-RS06192 HK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06287 HOOK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07100 KCNA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07373 KLK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14138 TAC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N10133 Licoflavanone / Unkown
HY-RS17121 Hk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23566 Hk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991810 Anti-Mouse Ly-6C Antibody (HK1.4) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hk1 NCBI NCBI:3098