Adra2a - adrenoceptor alpha 2A Gene

Also Known as RG20; CA2-47; RATRG20

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25083

Summary

Enables alpha2-adrenergic receptor activity. Involved in several processes, including glucose homeostasis; negative regulation of secretion by cell; and negative regulation of uterine smooth muscle contraction. Located in several cellular components, including axon terminus; neuronal cell body; and plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic active zone membrane. Used to study anxiety disorder and mental depression. Biomarker of hypertension and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A). [provided by Alliance of Genome Resources, Apr 2022]

Adra2a Products (1)

mRNA	Protein	Name
NM_012739.3	NP_036871.3	alpha-2A adrenergic receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables alpha2-adrenergic receptor activity	IDA IDA: Inferred from direct assay	1645350	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in DNA replication	IMP IMP: Inferred from mutant phenotype	15351511	RGD
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19965390	RGD
involved in female pregnancy	IMP IMP: Inferred from mutant phenotype	19450576	RGD
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	19965390	RGD
involved in negative regulation of calcium ion-dependent exocytosis	IMP IMP: Inferred from mutant phenotype	19965390	RGD
involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	19965390	RGD
involved in negative regulation of uterine smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	17664026	RGD
involved in response to alcohol	IEP IEP: Inferred from expression pattern	26121187	RGD
involved in response to morphine	IEP IEP: Inferred from expression pattern	9105684	RGD
involved in thermoception	IDA IDA: Inferred from direct assay	20110357	RGD
involved in vasodilation	IDA IDA: Inferred from direct assay	20837990	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	9596526	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	12379250	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	9596526	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	9596526	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12379250	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	9596526	RGD
is active in postsynaptic membrane	EXP EXP: Inferred from Experiment	9596526	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	9596526	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	9596526	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
alpha-2A adrenergic receptor	adrenergic receptor, alpha 2a adrenergic, alpha-2A-, receptor alpha-2A adrenoceptor alpha-2A adrenoreceptor alpha-2AAR alpha-2D adrenergic receptor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N8728	Aposcopolamine		98.23%	Unkown
HY-163694	ADRA2A antagonist 1	Antagonist	98.02%	Unkown
HY-145700	UCSF648		/	Unkown
HY-RS00411	ADRA2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-134125	Yohimbic acid ethyl ester	Antagonist	/	Unkown
HY-RS17718	Adra2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24183	Adra2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adra2a	NCBI	NCBI:150