ALPG - alkaline phosphatase, germ cell Gene

Also Known as GCAP; ALPPL; ALPPL2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 251

About ALPG

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:232,406,844-232,410,714 (from NCBI)

This gene has 1 transcript (splice variant), 361 orthologues and 3 paralogues. Biased expression in placenta (RPKM 6.1), lung (RPKM 0.8) and 1 other tissue.

Summary

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of Alkaline Phosphatase. [provided by RefSeq, Jul 2008]

ALPG Products (1)

mRNA Protein Name
NM_031313.3 NP_112603.2 alkaline phosphatase, germ cell type preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables alkaline phosphatase activity IDA
IDA: Inferred from direct assay
1939159 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALPG Protein Structure

Alk_phosphatase

Alk_phosphatase: Alkaline phosphatase (52 - 487)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 532 a.a.
Protein Preferred Names Protein Names

alkaline phosphatase, germ cell type

  • ALP-1

Recombinant ALPG Proteins

Cat. No. Product Name Accession Purity
HY-P700951 Alkaline Phosphatase/ALPG Protein, Human (Biotinylated, HEK293, His-Avi) P10696 (I20-D503) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700952 Alkaline Phosphatase/ALPG Protein, Human (HEK293, His) P10696 (I20-D503) ≥ 95%, as determined by reducing SDS-PAGE.

ALPG Antibodies

Cat. No. Product Name Application Reactivity
HY-P84049 ALPG Antibody (YA3746) WB, IHC-P, ICC/IF, FC, ELISA Human
HY-P84049A ALPG Antibody (YA3746)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Seminoma

  • Seminoma, Pure
Gonadoblastoma

  • GBY
Germ Cell Cancer

  • Malignant Germ Cell Tumor

  • Neoplasms, Germ Cell And Embryonal

  • Germ Cell Neoplasm

  • Germ Cell Tumour

  • Malignant Tumor Of The Germ Cell

  • Neoplasms Germ Cell

  • Malignant Germ Cell Neoplasm
Mixed Type Thymoma

  • Thymoma, Mixed Type

  • Thymoma, Type Ab
Endodermal Sinus Tumor

  • Yolk Sac Tumor

  • Endodermal Sinus Tumour

  • Hepatoid Yolk Sac Tumour

  • Infantile Embryonal Carcinoma

  • Yolk Sac Neoplasm

  • Yolk Sac Tumour
Dysgerminoma
Embryonal Carcinoma

  • Embryonal Neoplasm

  • Embryonal Cancer

  • Primary Extragonadal Embryonal Carcinoma

  • Embryo Neoplasm

  • Carcinoma Embryonal

  • Cancer Embryonal

  • Carcinoma, Embryonal

  • Extragonadal Embryonal Carcinoma

  • Cancer, Embryonal
Choriocarcinoma

  • Chorioepithelioma
Complete Androgen Insensitivity Syndrome

  • Cais

  • Complete Androgen Resistance Syndrome

  • Androgen Insensitivity Syndrome Complete

  • Androgen Insensitivity, Complete

  • Androgen-Insensitivity Syndrome

  • Testicular Feminization
Androgen Insensitivity Syndrome

  • Androgen Resistance Syndrome

  • AIS

  • Testicular Feminization Syndrome

  • Androgen Receptor Deficiency

  • Dhtr Deficiency

  • Dihydrotestosterone Receptor Deficiency

  • Ar Deficiency

  • Testicular Feminization

  • Tfm

  • Androgen Insensitivity

  • Androgen-Insensitivity Syndrome

  • Goldberg-Maxwell Syndrome

  • Complete Androgen Insensitivity Syndrome

  • Cais

  • Feminisation - Testicular

  • Goldberg - Maxwell Syndrome

  • Androgen Insensitivity Syndrome, Complete

  • Morris Syndrome

  • Ary

  • AR

  • Insensitivity Syndrome, Androgen

  • Androgen Insensitivity Nos
Testis Seminoma

  • Seminoma Of Testis

  • Seminoma Testis

  • Testicular Seminoma Pure

  • Seminoma
Hypophosphatasia

  • Phosphoethanolaminuria

  • Childhood Hypophosphatasia

  • Deficiency Of Alkaline Phosphatase

  • Hypophospatasia, Childhood

  • Hypophosphatasia Mild

  • Phosphoethanol-Aminuria

  • Rathburn Disease

  • Hpp

  • Rathbun Disease

  • Hypophosphatasia, Childhood

  • Infantile Hypophosphatasia
Cryptorchidism, Unilateral Or Bilateral

  • Cryptorchidism

  • Undescended Testicle

  • Undescended Testis

  • Cryptorchism

  • Undescended Testicles

  • CRYPTO

  • Impaired Testicular Descent

  • Cryptosporidiosis

  • Retained Testis

  • Unilateral Cryptorchidism

  • Unilateral Undescended Testis

  • Nondescent Unilateral Testicle

  • Unilateral Cryptorchism

  • Ectopic Testis, Unilateral

  • Bilateral Cryptorchidism

  • Bilateral Cryptorchism

  • Bilateral Nondescent Testicle

  • Bilateral Undescended Testes

  • Bilateral Ectopic Testes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00627 ALPG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28623 Alpg Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ALPG RGD RGD:1565100
Others ALPG NCBI