Casp1 - caspase 1 Gene

Also Known as Ice; p45; Il1bc

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25166

About Casp1

Primary_assembly 8: 2,587,831-2,597,383 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 456 orthologues, 12 paralogues and is associated with 40 phenotypes. Biased expression in Spleen (RPKM 365.4), Lung (RPKM 223.6) and 8 other tissues.

Summary

Enables scaffold protein binding activity. Involved in several processes, including myoblast fusion; positive regulation of circadian sleep/wake cycle, non-REM sleep; and positive regulation of interleukin-1 beta production. Located in cytoplasm; neuron projection; and nucleus. Part of protein-containing complex. Used to study acute kidney failure and visual epilepsy. Orthologous to human CASP1 (Caspase 1). [provided by Alliance of Genome Resources, Apr 2022]

Casp1 Products (1)

mRNA Protein Name
NM_012762.3 NP_036894.3 caspase-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18367607 RGD
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
19416975 RGD
Biological Process GO Annotation Evidence References Source
involved in lung development IEP
IEP: Inferred from expression pattern
12396474 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
16197515 RGD
involved in microglial cell activation IMP
IMP: Inferred from mutant phenotype
15149850 RGD
involved in midgut development IEP
IEP: Inferred from expression pattern
12396474 RGD
involved in myoblast fusion IMP
IMP: Inferred from mutant phenotype
12832042 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15663890 RGD
involved in positive regulation of circadian sleep/wake cycle, non-REM sleep IMP
IMP: Inferred from mutant phenotype
16455762 RGD
involved in positive regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
17384935 RGD
involved in positive regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
16942597 RGD
involved in response to hypoxia IDA
IDA: Inferred from direct assay
12829320 RGD
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
17384935 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
17561093 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
20638366 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
16165281 RGD
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
19416975 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp1 Protein Structure

CARD_CASP1-like

CARD_CASP1-like: cd08325 (5 - 86)

CASc

CASc: smart00115 (151 - 399)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
Protein Preferred Names Protein Names

caspase-1

  • IL-1 beta-converting enzyme

  • Interleukin 1beta converting enzyme

  • interleukin 1, beta, convertase

  • interleukin-1 beta-converting enzyme

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp1 NCBI NCBI:834