Ghr - growth hormone receptor Gene

Also Known as GHR/BP

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25235

Summary

Enables SH2 domain binding activity; enzyme binding activity; and growth hormone receptor activity. Involved in several processes, including activation of Janus kinase activity; cellular response to hormone stimulus; and receptor signaling pathway via JAK-STAT. Located in several cellular components, including extracellular space; mitochondrion; and neuronal cell body. Biomarker of congenital hypothyroidism; muscular atrophy; osteopetrosis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Orthologous to human GHR (growth hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ghr Products (1)

mRNA Protein Name
NM_017094.2 NP_058790.1 growth hormone receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH2 domain binding IDA
IDA: Inferred from direct assay
12586763 RGD
enables SH2 domain binding IMP
IMP: Inferred from mutant phenotype
10976913 RGD
enables SH2 domain binding IPI
IPI: Inferred from physical interaction
10976913 RGD
enables growth hormone receptor activity IDA
IDA: Inferred from direct assay
11244571 RGD
enables protein kinase binding IDA
IDA: Inferred from direct assay
8063815 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
11244571 RGD
enables protein phosphatase binding IMP
IMP: Inferred from mutant phenotype
10976913 RGD
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
10976913 RGD
Biological Process GO Annotation Evidence References Source
involved in activation of Janus kinase activity IDA
IDA: Inferred from direct assay
11244571 RGD
involved in cartilage development involved in endochondral bone morphogenesis IEP
IEP: Inferred from expression pattern
15749813 RGD
involved in cell surface receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
8063815 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
18040895 RGD
involved in growth hormone receptor signaling pathway IDA
IDA: Inferred from direct assay
8063815 RGD
involved in hormone-mediated signaling pathway IDA
IDA: Inferred from direct assay
11064147 RGD
acts upstream of positive regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
8063815 RGD
involved in positive regulation of cell differentiation IEP
IEP: Inferred from expression pattern
12162495 RGD
involved in positive regulation of receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
11064147 RGD
involved in positive regulation of receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
10976913 RGD
involved in regulation of response to nutrient levels IMP
IMP: Inferred from mutant phenotype
17258692 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
12654216 RGD
involved in response to food IEP
IEP: Inferred from expression pattern
17634149 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
12162495 RGD
involved in response to gravity IEP
IEP: Inferred from expression pattern
14638460 RGD
involved in response to growth hormone IEP
IEP: Inferred from expression pattern
10987684 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
12162495 RGD
involved in response to interleukin-1 IEP
IEP: Inferred from expression pattern
14518239 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
15334695 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
11126270 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
17258692 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth hormone receptor

  • GH receptor

  • growth hormone receptor variant d5-6

  • growth hormone receptor/binding protein

  • somatotropin receptor

Recombinant Ghr Proteins

Cat. No. Product Name Accession Purity
HY-P73088 Growth Hormone Receptor/GHR Protein, Rat (HEK293, Fc) P16310-1 (F19-R265) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73089 Growth Hormone Receptor/GHR Protein, Rat (HEK293, His) P16310-1 (F19-R265) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-164419A Atesidorsen sodium Inhibitor 98.58% Phase 2
HY-153485 Cimdelirsen Inhibitor / Phase 2
HY-153485A Cimdelirsen sodium Inhibitor / Phase 2
HY-164419 Atesidorsen Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10283 S1H Antagonist 99.32% Unkown
HY-156373 MN714 Inhibitor 99.12% Unkown
HY-159697 ISIS 532401 / Unkown
HY-159697A ISIS 532401 sodium / Unkown
HY-RS05412 GHR Human Pre-designed siRNA Set A / Unkown
HY-RS16936 Ghr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20741 Ghrl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23379 Ghr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ghr NCBI NCBI:2690