Gclc - glutamate-cysteine ligase, catalytic subunit Gene

Also Known as Glclc

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25283

Summary

Enables glutamate-cysteine Ligase activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and cellular response to mechanical stimulus. Part of glutamate-cysteine Ligase complex. Used to study liver cirrhosis and pulmonary emphysema. Human ortholog(s) of this gene implicated in cystic fibrosis; glutamate-cysteine Ligase deficiency; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine Ligase catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Gclc Products (1)

mRNA Protein Name
NM_012815.2 NP_036947.1 glutamate--cysteine ligase catalytic subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutamate-cysteine ligase activity IDA
IDA: Inferred from direct assay
12425961 RGD
enables glutamate-cysteine ligase activity IMP
IMP: Inferred from mutant phenotype
16183645 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
16137247 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: Inferred from expression pattern
18042181 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: Inferred from expression pattern
18042181 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
20466058 RGD
involved in cellular response to hepatocyte growth factor stimulus IEP
IEP: Inferred from expression pattern
20466058 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
15169830 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
20054150 RGD
involved in cellular response to thyroxine stimulus IEP
IEP: Inferred from expression pattern
17291985 RGD
involved in glutathione biosynthetic process IMP
IMP: Inferred from mutant phenotype
16183645 RGD
involved in negative regulation of hepatic stellate cell activation IMP
IMP: Inferred from mutant phenotype
22942279 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
16183645 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
20018823 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
10702364 RGD
involved in response to human chorionic gonadotropin IEP
IEP: Inferred from expression pattern
15811874 RGD
involved in response to interleukin-1 IEP
IEP: Inferred from expression pattern
15485876 RGD
involved in response to nitrosative stress IMP
IMP: Inferred from mutant phenotype
16183645 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
22906634 RGD
involved in response to oxidative stress IMP
IMP: Inferred from mutant phenotype
16183645 RGD
Cellular Component GO Annotation Evidence References Source
part of glutamate-cysteine ligase complex IDA
IDA: Inferred from direct assay
16137247 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate--cysteine ligase catalytic subunit

  • GCS heavy chain

  • Glutamylcysteine gamma synthetase light chain

  • gamma-ECS

  • gamma-glutamylcysteine synthetase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W015600 2-Acetamidophenol 99.73% Unkown
HY-171705 KMS99220 99.48% Unkown
HY-N1970 5,7-Dihydroxychromone 99.94% Unkown
HY-147517 Keap1-Nrf2-IN-9 Inhibitor 98.52% Unkown
HY-W015600S 2-Acetamidophenol-d3 99.48% Unkown
HY-RS05333 GCLC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-184266 GCLCi0 Inducer / Unkown
HY-184267 GCLCi1 / Unkown
HY-N17732 7-Hydroxy-5,3'4'-trimethoxyflavanone / Unkown
HY-N17855 Guavinoside B Inhibitor / Unkown
HY-N1970R 5,7-Dihydroxychromone (Standard) / Unkown
HY-RS17688 Gclc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24150 Gclc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gclc NCBI NCBI:2729