country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

GCLC - glutamate-cysteine ligase catalytic subunit Gene

Also Known as GCL; GCS; GLCL; GLCLC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2729

About GCLC

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:53,497,341-53,545,101 (from NCBI)

This gene has 14 transcripts (splice variants), 219 orthologues and is associated with 4 phenotypes. Ubiquitous expression in liver (RPKM 39.8), urinary bladder (RPKM 19.1) and 24 other tissues.

Summary

Glutamate-cysteine Ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]

GCLC Products (2)

mRNA	Protein	Name
NM_001197115.2	NP_001184044.1	glutamate--cysteine ligase catalytic subunit isoform b
NM_001498.4	NP_001489.1	glutamate--cysteine ligase catalytic subunit isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ADP binding	IDA IDA: Inferred from direct assay	24639	GOA
enables glutamate binding	IDA IDA: Inferred from direct assay	9841880	GOA
enables glutamate-cysteine ligase activity	IDA IDA: Inferred from direct assay	8104187	GOA
enables glutamate-cysteine ligase activity	IMP IMP: Inferred from mutant phenotype	9841880	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	24639	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9675072	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in blood vessel diameter maintenance	IMP IMP: Inferred from mutant phenotype	12598062	GOA
involved in cell redox homeostasis	IDA IDA: Inferred from direct assay	10439045	GOA
involved in cysteine metabolic process	IDA IDA: Inferred from direct assay	2294991	GOA
involved in glutamate metabolic process	IDA IDA: Inferred from direct assay	2294991	GOA
involved in glutathione biosynthetic process	IDA IDA: Inferred from direct assay	8104187	GOA
involved in glutathione biosynthetic process	IMP IMP: Inferred from mutant phenotype	12663448	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10439045	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	10439045	GOA
involved in response to heat	IDA IDA: Inferred from direct assay	8104187	GOA
involved in response to hormone	IDA IDA: Inferred from direct assay	8104187	GOA
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	10395918	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of glutamate-cysteine ligase complex	IDA IDA: Inferred from direct assay	9675072	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GCLC Protein Structure

GCS

0
100
200
300
400
500
600
637 a.a.

Protein Preferred Names	Protein Names
glutamate--cysteine ligase catalytic subunit	GCS heavy chain

GCLC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GCLC	P48506	GCLM	Homo sapiens	P48507	Anti Tag CoIP	28514442
Intra	GCLC	P48506	GCLM	Homo sapiens	P48507	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

GCLC Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83153	GCLC Antibody (YA2898)	WB	Human, Mouse, Rat
HY-P83153A	GCLC Antibody (YA2898)(PBS only)	WB	Human, Mouse, Rat
HY-P86305	GCLC Antibody (YA5997)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Gamma-Glutamylcysteine Synthetase Deficiency, Hemolytic Anemia Due To	Hemolytic Anemia Due To Gamma-Glutamylcysteine Synthetase Deficiency HAGGSD Anemia, Hemolytic, Due To Gamma-Glutamylcysteine Synthetase Deficiency Glutamate-Cysteine Ligase Deficiency
Glutamate-Cysteine Ligase Deficiency	Gamma-Glutamylcysteine Synthetase Deficiency Hemolytic Anemia Due To Gamma-Glutamylcysteine Synthetase Deficiency Gamma-Glutamylcysteine Synthetase Deficiency, Hemolytic Anemia Due To
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Autosomal Dominant Adult-Onset Proximal Spinal Muscular Atrophy	Autosomal Dominant Adult-Onset Proximal Sma Autosomal Dominant Late-Onset Spinal Muscular Atrophy, Finkel Type Finkel Disease Smafk Adult-Onset Proximal Spinal Muscular Atrophy, Autosomal Dominant Autosomal Dominant Adult Proximal Spinal Muscular Atrophy Finkel Late-Adult Type Sma
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Co-Trimoxazole Allergy	Bactrim Allergy Cotrimoxazol Allergy Tmp/Smx Allergy Trimethoprim/Sulfamethoxazole Allergy
Intravascular Fasciitis	Intravascular Pseudosarcomatous Fasciitis
Myopathy	Muscular Diseases Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W015600	2-Acetamidophenol		99.73%	Unkown
HY-171705	KMS99220		99.48%	Unkown
HY-N1970	5,7-Dihydroxychromone		99.94%	Unkown
HY-147517	Keap1-Nrf2-IN-9	Inhibitor	98.52%	Unkown
HY-W015600S	2-Acetamidophenol-d3		99.48%	Unkown
HY-RS05333	GCLC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-184266	GCLCi0	Inducer	/	Unkown
HY-184267	GCLCi1		/	Unkown
HY-N17732	7-Hydroxy-5,3'4'-trimethoxyflavanone		/	Unkown
HY-N17855	Guavinoside B	Inhibitor	/	Unkown
HY-N1970R	5,7-Dihydroxychromone (Standard)		/	Unkown
HY-RS17688	Gclc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24150	Gclc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GCLC	VGNC	VGNC:72923
Canis familiaris	GCLC	VGNC	VGNC:41147
Mus musculus	GCLC	MGD	MGI:104990
Rattus norvegicus	GCLC	RGD	RGD:619868
Bos taurus	GCLC	VGNC	VGNC:29289
Felis catus	GCLC	VGNC	VGNC:62494
Others	GCLC	NCBI