Smad1 - SMAD family member 1 Gene

Also Known as Madh1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25671

Summary

Predicted to enable several functions, including SMAD binding activity; enzyme binding activity; and nucleic acid binding activity. Involved in several processes, including BMP signaling pathway; negative regulation of muscle cell apoptotic process; and positive regulation of dendrite morphogenesis. Located in cytoplasm and nucleus. Used to study pulmonary hypertension. Biomarker of glomerulonephritis; male infertility; nephrotic syndrome; and pulmonary hypertension. Orthologous to human SMAD1 (Smad Family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Smad1 Products (2)

mRNA Protein Name
NM_013130.3 NP_037262.3 mothers against decapentaplegic homolog 1
NM_013130.3 NP_037262.3 mothers against decapentaplegic homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12552124 RGD
Biological Process GO Annotation Evidence References Source
involved in BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
16020542 RGD
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
16427075 RGD
involved in cardiac muscle hypertrophy in response to stress IMP
IMP: Inferred from mutant phenotype
26873969 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
11850197 RGD
involved in negative regulation of muscle cell apoptotic process IEP
IEP: Inferred from expression pattern
11408477 RGD
involved in positive regulation of cell differentiation IDA
IDA: Inferred from direct assay
17525996 RGD
involved in positive regulation of dendrite morphogenesis IEP
IEP: Inferred from expression pattern
15056710 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
18079356 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mothers against decapentaplegic homolog 1

  • MAD (mothers against decapentaplegic, Drosophila) homolog 1

  • MAD homolog 1

  • MAD homolog1 (mothers against decapentaplegic, Drosophila)

  • SMAD 1

  • SMAD, mothers against DPP homolog 1

  • mothers against DPP homolog 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112499 Menaquinone-7 Activator 98.51% Phase 2

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5542 Vicatertide Inhibitor 99.24% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smad1 NCBI NCBI:4086