S100b - S100 calcium binding protein B Gene

Also Known as S100P

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25742

Summary

Enables RAGE receptor binding activity; identical protein binding activity; and metal ion binding activity. Involved in several processes, including long-term synaptic potentiation; negative regulation of skeletal muscle cell differentiation; and positive regulation of myelination. Located in cytoplasm and extracellular space. Used to study demyelinating disease. Biomarker of several diseases, including bipolar disorder; borna disease; brain disease (multiple); mental depression; and sleep apnea. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; aspergillosis; and schizophrenia. Orthologous to human S100B (S100 calcium binding protein B). [provided by Alliance of Genome Resources, Apr 2022]

S100b Products (1)

mRNA	Protein	Name
NM_013191.2	NP_037323.1	protein S100-B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RAGE receptor binding	IPI IPI: Inferred from physical interaction	19910580	RGD
enables calcium ion binding	IDA IDA: Inferred from direct assay	14621986	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	18949447	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19910580	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	18445708	RGD
enables zinc ion binding	IDA IDA: Inferred from direct assay	14621986	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in astrocyte differentiation	IEP IEP: Inferred from expression pattern	19147496	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	19910580	RGD
involved in long-term synaptic potentiation	IEP IEP: Inferred from expression pattern	21546003	RGD
involved in negative regulation of skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	20069545	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17639288	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	2229184	RGD
involved in positive regulation of myelination	IMP IMP: Inferred from mutant phenotype	25536222	RGD
involved in positive regulation of synaptic transmission	IMP IMP: Inferred from mutant phenotype	12428274	RGD
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	2229184	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	16112204	RGD
involved in response to methylmercury	IEP IEP: Inferred from expression pattern	21783483	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	21098642	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein S100-B	S-100 protein beta chain S-100 protein subunit beta S100 calcium-binding protein, beta (neural) S100 protein, beta polypeptide, neural

S100b Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	S100b	P04631	Ager	Rattus norvegicus	Q63495	Anti Bait CoIP	19910580

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16918A	Heptamidine dimethanesulfonate	Inhibitor	99.12%	Unkown
HY-16918	Heptamidine		/	Unkown
HY-RS12387	S100B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W237439	SEN205A	Ligand	/	Unkown
HY-RS16975	S100b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23418	S100b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	S100b	NCBI	NCBI:6285