S100B - S100 calcium binding protein B Gene
Also Known as NEF; S100; S100-B; S100beta
Species: Homo sapiens
About S100B
This gene has 3 transcripts (splice variants), 161 orthologues and 21 paralogues. Biased expression in brain (RPKM 150.1), fat (RPKM 102.5) and 2 other tissues.
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and Other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]
S100B Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_006272.3 | NP_006263.1 | protein S100-B |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables RAGE receptor binding |
IPI
IPI: Inferred from physical interaction
|
15033494 | GOA |
| enables S100 protein binding |
IPI
IPI: Inferred from physical interaction
|
9519411 | GOA |
| enables calcium ion binding |
IDA
IDA: Inferred from direct assay
|
20950652 | GOA |
| enables calcium-dependent protein binding |
IDA
IDA: Inferred from direct assay
|
10913138 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
9519411 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
3111527 | GOA |
| enables protein homodimerization activity |
IDA
IDA: Inferred from direct assay
|
10913138 | GOA |
| enables protein homodimerization activity |
IPI
IPI: Inferred from physical interaction
|
9519411 | GOA |
| enables zinc ion binding |
IDA
IDA: Inferred from direct assay
|
20950652 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in positive regulation of canonical NF-kappaB signal transduction |
IDA
IDA: Inferred from direct assay
|
15033494 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
10913138 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
10913138 | GOA |
| located in perinuclear region of cytoplasm |
IDA
IDA: Inferred from direct assay
|
12118070 | GOA |
| located in ruffle |
IDA
IDA: Inferred from direct assay
|
10913138 | GOA |
S100B Protein Structure
S_100: S-100/ICaBP type calcium binding domain (4 - 46)
- 0
- 92 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
protein S100-B |
|
S100B Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
S100B | P04271 | S100A9 | Homo sapiens | P06702 | 32296183 | |
|
Intra
|
S100B | P04271 | HSPA1A | Homo sapiens | P0DMV8 | 32814053 | |
|
Intra
|
S100B | P04271 | HSPA1A | Homo sapiens | P0DMV8 | 32814053 | |
|
Intra
|
S100B | P04271 | HSPA1A | Homo sapiens | P0DMV8 | 32814053 | |
|
Intra
|
S100B | P04271 | S100A1 | Homo sapiens | Q5T7Y6 | 27107012 | |
|
Intra
|
S100B | P04271 | S100Z | Homo sapiens | Q8WXG8 | 32296183 | |
|
Intra
|
S100B | P04271 | CAMK2A | Homo sapiens | Q9UQM7 | 32814053 | |
|
Intra
|
S100B | P04271 | CAMK2A | Homo sapiens | Q9UQM7 | 32814053 | |
|
Intra
|
S100B | P04271 | CAMK2A | Homo sapiens | Q9UQM7 | 32814053 | |
|
Intra
|
S100B | P04271 | AGER | Homo sapiens | Q15109 | 17660747 | |
|
Intra
|
S100B | P04271 | APLP2 | Homo sapiens | Q06481-5 | 32814053 | |
|
Intra
|
S100B | P04271 | APLP2 | Homo sapiens | Q06481-5 | 32814053 | |
|
Intra
|
S100B | P04271 | APLP2 | Homo sapiens | Q06481-5 | 32814053 | |
|
Intra
|
S100B | P04271 | UNG | Homo sapiens | P13051-2 | 32814053 | |
|
Intra
|
S100B | P04271 | UNG | Homo sapiens | P13051-2 | 32814053 | |
|
Intra
|
S100B | P04271 | UNG | Homo sapiens | P13051-2 | 32814053 | |
|
Intra
|
S100B | P04271 | CANX | Homo sapiens | P27824-2 | 32814053 | |
|
Intra
|
S100B | P04271 | CANX | Homo sapiens | P27824-2 | 32814053 | |
|
Intra
|
S100B | P04271 | CANX | Homo sapiens | P27824-2 | 32814053 | |
|
Intra
|
S100B | P04271 | SEPTIN8 | Homo sapiens | Q92599-3 | 32814053 | |
|
Intra
|
S100B | P04271 | SEPTIN8 | Homo sapiens | Q92599-3 | 32814053 | |
|
Intra
|
S100B | P04271 | SEPTIN8 | Homo sapiens | Q92599-3 | 32814053 | |
|
Intra
|
S100B | P04271 | MYH9 | Homo sapiens | P35579 | 31837246 | |
|
Intra
|
S100B | P04271 | S100A6 | Homo sapiens | P06703 | 10913138 | |
|
Intra
|
S100B | P04271 | S100A6 | Homo sapiens | P06703 | 10913138 | |
|
Intra
|
S100B | P04271 | S100A6 | Homo sapiens | P06703 | 10913138 | |
|
Intra
|
S100B | P04271 | CAPZA1 | Homo sapiens | P52907 | 31837246 | |
|
Intra
|
S100B | P04271 | CAPZA1 | Homo sapiens | P52907 | 31837246 | |
|
Intra
|
S100B | P04271 | PPP1CA | Homo sapiens | P62136 | 32814053 | |
|
Intra
|
S100B | P04271 | PPP1CA | Homo sapiens | P62136 | 32814053 | |
|
Intra
|
S100B | P04271 | PPP1CA | Homo sapiens | P62136 | 32814053 | |
|
Intra
|
S100B | P04271 | TP53 | Homo sapiens | P04637 | 20591429 | |
|
Intra
|
S100B | P04271 | TP53 | Homo sapiens | P04637 | 31837246 | |
|
Intra
|
S100B | P04271 | MDM2 | Homo sapiens | Q00987 | 20591429 | |
|
Intra
|
S100B | P04271 | MDM2 | Homo sapiens | Q00987 | 20591429 | |
|
Intra
|
S100B | P04271 | MDM4 | Homo sapiens | O15151 | 31837246 | |
|
Intra
|
S100B | P04271 | MDM4 | Homo sapiens | O15151 | 31837246 | |
|
Intra
|
S100B | P04271 | S100A1 | Homo sapiens | P23297 | 25416956 | |
|
Intra
|
S100B | P04271 | S100A1 | Homo sapiens | P23297 | 32296183 | |
|
Intra
|
S100B | P04271 | S100A1 | Homo sapiens | P23297 | 10913138 | |
|
Intra
|
S100B | P04271 | S100A1 | Homo sapiens | P23297 | 21516116 | |
|
Intra
|
S100B | P04271 | S100A1 | Homo sapiens | P23297 | 25416956 | |
|
Intra
|
S100B | P04271 | S100A1 | Homo sapiens | P23297 | 26871637 | |
|
Intra
|
S100B | P04271 | S100A1 | Homo sapiens | P23297 | 32296183 | |
|
Intra
|
S100B | P04271 | S100A1 | Homo sapiens | P23297 | 25416956 | |
|
Intra
|
S100B | P04271 | S100A1 | Homo sapiens | P23297 | 26871637 | |
|
Intra
|
S100B | P04271 | S100A1 | Homo sapiens | P23297 | 32296183 | |
|
Intra
|
S100B | P04271 | S100A1 | Homo sapiens | P23297 | 26871637 | |
|
Intra
|
S100B | P04271 | S100A1 | Homo sapiens | P23297 | 25416956 | |
|
Intra
|
S100B | P04271 | S100A1 | Homo sapiens | P23297 | 26871637 | |
|
Intra
|
S100B | P04271 | PRKACA | Homo sapiens | P17612 | 32814053 | |
|
Intra
|
S100B | P04271 | PRKACA | Homo sapiens | P17612 | 32814053 | |
|
Intra
|
S100B | P04271 | PRKACA | Homo sapiens | P17612 | 32814053 | |
|
Intra
|
S100B | P04271 | A2M | Homo sapiens | P01023 | 32814053 | |
|
Intra
|
S100B | P04271 | A2M | Homo sapiens | P01023 | 32814053 | |
|
Intra
|
S100B | P04271 | A2M | Homo sapiens | P01023 | 32814053 | |
|
Intra
|
S100B | P04271 | S100A11 | Homo sapiens | P31949 | 10913138 | |
|
Intra
|
S100B | P04271 | S100A11 | Homo sapiens | P31949 | 10913138 | |
|
Intra
|
S100B | P04271 | S100A11 | Homo sapiens | P31949 | 10913138 | |
|
Intra
|
S100B | P04271 | ZNF24 | Homo sapiens | P17028 | 32814053 | |
|
Intra
|
S100B | P04271 | ZNF24 | Homo sapiens | P17028 | 32814053 | |
|
Intra
|
S100B | P04271 | ZNF24 | Homo sapiens | P17028 | 32814053 | |
|
Intra
|
S100B | P04271 | CRCT1 | Homo sapiens | Q9UGL9 | 32814053 | |
|
Intra
|
S100B | P04271 | CRCT1 | Homo sapiens | Q9UGL9 | 32814053 | |
|
Intra
|
S100B | P04271 | CRCT1 | Homo sapiens | Q9UGL9 | 32814053 | |
|
Intra
|
S100B | P04271 | NEDD8 | Homo sapiens | Q15843 | 32814053 | |
|
Intra
|
S100B | P04271 | NEDD8 | Homo sapiens | Q15843 | 32814053 | |
|
Intra
|
S100B | P04271 | NEDD8 | Homo sapiens | Q15843 | 32814053 | |
|
Intra
|
S100B | P04271 | S100A4 | Homo sapiens | P26447 | 25416956 | |
|
Intra
|
S100B | P04271 | S100A4 | Homo sapiens | P26447 | 25416956 | |
|
Intra
|
S100B | P04271 | S100A4 | Homo sapiens | P26447 | 32296183 | |
|
Intra
|
S100B | P04271 | S100A4 | Homo sapiens | P26447 | 25416956 | |
|
Intra
|
S100B | P04271 | S100A4 | Homo sapiens | P26447 | 26496610 | |
|
Intra
|
S100B | P04271 | BLMH | Homo sapiens | Q13867 | 32814053 | |
|
Intra
|
S100B | P04271 | BLMH | Homo sapiens | Q13867 | 32814053 | |
|
Intra
|
S100B | P04271 | BLMH | Homo sapiens | Q13867 | 32814053 | |
|
Intra
|
S100B | P04271 | ERBB3 | Homo sapiens | P21860 | 32814053 | |
|
Intra
|
S100B | P04271 | ERBB3 | Homo sapiens | P21860 | 32814053 | |
|
Intra
|
S100B | P04271 | ERBB3 | Homo sapiens | P21860 | 32814053 | |
|
Intra
|
S100B | P04271 | LNX1 | Homo sapiens | Q8TBB1 | 32296183 | |
|
Intra
|
S100B | P04271 | SPG21 | Homo sapiens | Q9NZD8 | 32296183 | |
|
Intra
|
S100B | P04271 | SPG21 | Homo sapiens | Q9NZD8 | 25416956 | |
|
Intra
|
S100B | P04271 | SPG21 | Homo sapiens | Q9NZD8 | 31515488 | |
|
Intra
|
S100B | P04271 | S100P | Homo sapiens | P25815 | 25416956 | |
|
Intra
|
S100B | P04271 | S100P | Homo sapiens | P25815 | 26496610 | |
|
Intra
|
S100B | P04271 | S100P | Homo sapiens | P25815 | 32296183 | |
|
Intra
|
S100B | P04271 | S100A2 | Homo sapiens | P29034 | 26871637 | |
|
Intra
|
S100B | P04271 | S100A2 | Homo sapiens | P29034 | 32296183 | |
|
Intra
|
S100B | P04271 | S100A2 | Homo sapiens | P29034 | 32296183 | |
|
Intra
|
S100B | P04271 | S100A2 | Homo sapiens | P29034 | 25416956 | |
|
Intra
|
S100B | P04271 | S100A2 | Homo sapiens | P29034 | 32296183 | |
|
Intra
|
S100B | P04271 | S100A2 | Homo sapiens | P29034 | 26871637 | |
|
Intra
|
S100B | P04271 | S100A2 | Homo sapiens | P29034 | 26871637 | |
|
Intra
|
S100B | P04271 | S100A2 | Homo sapiens | P29034 | 25416956 | |
|
Intra
|
S100B | P04271 | APP | Homo sapiens | P05067 | 32814053 | |
|
Intra
|
S100B | P04271 | APP | Homo sapiens | P05067 | 32814053 | |
|
Intra
|
S100B | P04271 | APP | Homo sapiens | P05067 | 32814053 | |
|
Intra
|
S100B | P04271 | CSNK1D | Homo sapiens | P48730-2 | 32814053 | |
|
Intra
|
S100B | P04271 | CSNK1D | Homo sapiens | P48730-2 | 32814053 | |
|
Intra
|
S100B | P04271 | CSNK1D | Homo sapiens | P48730-2 | 32814053 | |
|
Intra
|
S100B | P04271 | RPS6KA1 | Homo sapiens | Q15418 | 31837246 |
Recombinant S100B Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70659 | S100B Protein, Human (His) | P04271 (M1-E92) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P73391 | S100B Protein, Human (HEK293, Fc) | NP_006263.1 (S2-E92) | ≥ 95%, as determined by reducing SDS-PAGE. |
S100B Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80891 | S100B Antibody | WB, IHC-P, ICC/IF, IP | Human, Mouse, Rat, Goat |
| HY-P83943 | S100B Antibody (YA3640) | IHC-P, ELISA | Human |
| HY-P83943A | S100B Antibody (YA3640)(PBS only) | IHC-P, ELISA | Human |
| HY-P86372 | S100B Antibody (YA6064) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Neurofibroma |
|
|
| Syringoma |
|
|
| Myxopapillary Ependymoma |
|
|
| Subependymal Giant Cell Astrocytoma |
|
|
| Granular Cell Tumor |
|
|
| Clear Cell Sarcoma |
|
|
| Myoepithelioma |
|
|
| Perineurioma |
|
|
| Histiocytosis |
|
|
| Pleomorphic Adenoma |
|
|
| Creutzfeldt-Jakob Disease |
|
|
| Malignant Peripheral Nerve Sheath Tumor |
|
|
| Fibrous Meningioma |
|
|
| Chordoma |
|
|
| Langerhans Cell Histiocytosis |
|
|
| Dermatofibrosarcoma Protuberans |
|
|
| Secondary Progressive Multiple Sclerosis |
|
|
| Olfactory Neuroblastoma |
|
|
| Amelanotic Melanoma |
|
|
| Neurilemmoma |
|
|
| Ganglioglioma |
|
|
| Tuberous Sclerosis |
|
|
| Primary Progressive Multiple Sclerosis |
|
|
| Gastrointestinal Stromal Tumor |
|
|
| Cardiac Arrest |
|
|
| Fibrous Histiocytoma |
|
|
| Post-Cardiac Arrest Syndrome |
|
|
| Melanoma In Congenital Melanocytic Nevus |
|
|
| Gemistocytic Astrocytoma |
|
|
| Papilloma Of Choroid Plexus |
|
|
| Neuroma |
|
|
| Choroid Plexus Cancer |
|
|
| Chondrosarcoma |
|
|
| Neuroendocrine Carcinoma |
|
|
| Pineocytoma |
|
|
| Carotid Stenosis |
|
|
| Hemangioblastoma |
|
|
| Paraganglioma |
|
|
| Leiomyosarcoma |
|
|
| Salivary Gland Adenoma, Pleomorphic |
|
|
| Histiocytosis-Lymphadenopathy Plus Syndrome |
|
|
| Asphyxia Neonatorum |
|
|
| Papillary Ependymoma |
|
|
| Hemiplegia |
|
|
| Ganglioneuroblastoma |
|
|
| Malignant Fibrous Histiocytoma |
|
|
| Hepatic Encephalopathy |
|
|
| Neuromyelitis Optica |
|
|
| Down Syndrome |
|
|
| Adenoid Cystic Carcinoma |
|
|
| Intestinal Pseudo-Obstruction |
|
|
| Status Epilepticus |
|
|
| Blastoma |
|
|
| Melanoma |
|
|
| Myocardial Infarction |
|
|
| Sarcoma |
|
|
| Hand, Foot And Mouth Disease |
|
|
| Immune Deficiency Disease |
|
|
| Epidermoid Cysts |
|
|
| Microphthalmia |
|
|
| Anaplastic Ependymoma |
|
|
| Pilocytic Astrocytoma |
|
|
| Human Immunodeficiency Virus Type 1 |
|
|
| Glomus Tumor |
|
|
| Oligodendroglioma |
|
|
| Cellular Ependymoma |
|
|
| Neurofibromatosis, Type I |
|
|
| Melanoma, Uveal |
|
|
| Spindle Cell Sarcoma |
|
|
| Epilepsy |
|
|
| Akinetic Mutism |
|
|
| Rhabdomyosarcoma |
|
|
| Ganglioneuroma |
|
|
| Middle Cerebral Artery Infarction |
|
|
| Ewing Sarcoma |
|
|
| Sarcoma, Synovial |
|
|
| Inner Ear Disease |
|
|
| Medulloblastoma |
|
|
| Meningioma, Familial |
|
|
| Achalasia |
|
|
| Hydrocephalus |
|
|
| Dedifferentiated Liposarcoma |
|
|
| Pilomatrixoma |
|
|
| Dyslexia |
|
|
| Meningitis |
|
|
| Cutaneous Fibrous Histiocytoma |
|
|
| Constipation |
|
|
| Intracranial Vasospasm |
|
|
| Mouth Disease |
|
|
| Gliosarcoma |
|
|
| Cerebral Palsy |
|
|
| Machado-Joseph Disease |
|
|
| Hemangiopericytoma, Malignant |
|
|
| Supratentorial Meningioma |
|
|
| Mixed Type Thymoma |
|
|
| Jejunoileitis |
|
|
| Neural Tube Defects |
|
|
| Castleman Disease |
|
|
| Amnestic Disorder |
|
|
| Intracranial Berry Aneurysm |
|
|
| Paranoid Schizophrenia |
|
|
| Benign Giant Cell Tumor |
|
|
| Intracranial Hypertension |
|
|
| Encephalomalacia |
|
|
| Gastroesophageal Reflux |
|
|
| Periventricular Leukomalacia |
|
|
| Plexiform Neurofibroma |
|
|
| Bipolar Disorder |
|
|
| Sex Cord-Gonadal Stromal Tumor |
|
|
| Alexander Disease |
|
|
| Chromosomal Duplication Syndrome |
|
|
| Cerebral Arterial Disease |
|
|
| Phenytoin Allergy |
|
|
| Esophageal Atresia |
|
|
| Cerebral Degeneration |
|
|
| Schizophrenia |
|
|
| Hirschsprung Disease 1 |
|
|
| Migraine With Or Without Aura 1 |
|
|
| Nervous System Disease |
|
|
| Peripheral Nervous System Disease |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | S100B | MGD | MGI:98217 |
| Macaca mulatta | S100B | VGNC | VGNC:81754 |
| Rattus norvegicus | S100B | RGD | RGD:3615 |
| Canis familiaris | S100B | VGNC | VGNC:49642 |
| Bos taurus | S100B | VGNC | VGNC:34248 |
| Felis catus | S100B | VGNC | VGNC:102837 |
| Others | S100B | NCBI |