QPCT - glutaminyl-peptide cyclotransferase Gene

Also Known as QC; GCT; sQC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25797

About QPCT

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:37,344,630-37,373,322 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 1 paralogue. Biased expression in adrenal (RPKM 75.9), bone marrow (RPKM 17.6) and 13 other tissues.

Summary

This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]

QPCT Products (1)

mRNA Protein Name
NM_012413.4 NP_036545.1 glutaminyl-peptide cyclotransferase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables glutaminyl-peptide cyclotransferase activity IDA
IDA: Inferred from direct assay
21288892 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
21288892 GOA
Biological Process GO Annotation Evidence References Source
involved in peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IDA
IDA: Inferred from direct assay
21288892 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

QPCT Protein Structure

Peptidase_M28

Peptidase_M28: Peptidase family M28 (134 - 344)

  • 0
  • 100
  • 200
  • 300
  • 361 a.a.
Protein Preferred Names Protein Names

glutaminyl-peptide cyclotransferase

  • EC

QPCT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
QPCT Q16769 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
QPCT Q16769 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
QPCT Q16769 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant QPCT Proteins

Cat. No. Product Name Accession Purity
HY-P76560 QPCT Protein, Human (sf9, His) Q16769-1 (A33-L361) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cerebral Amyloid Angiopathy, Itm2b-Related, 1

  • Dementia, Familial British

  • Fbd

  • Presenile Dementia With Spastic Ataxia

  • Familial British Dementia

  • Abri Amyloidosis

  • Cerebral Amyloid Angiopathy, British Type

  • Itm2b-Related Cerebral Amyloid Angiopathy 1

  • Familial Dementia, British Type

  • Cerebral Amyloid Angiopathy, Itm2b-Related 1

  • CAA-ITM2B1

  • Cerebral Amyloid Angiopathy British Type

  • Dementia, Familial, British
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11501 QPCT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17334 Qpct Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23790 Qpct Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus QPCT VGNC VGNC:33598
Mus musculus QPCT MGD MGI:1917786
Macaca mulatta QPCT VGNC VGNC:76636
Felis catus QPCT VGNC VGNC:69199
Rattus norvegicus QPCT RGD RGD:1562284
Canis familiaris QPCT VGNC VGNC:45233
Others QPCT NCBI