PRDX5 - peroxiredoxin 5 Gene

Also Known as PLP; ACR1; B166; PRXV; PMP20; PRDX6; prx-V; SBBI10; AOEB166; HEL-S-55

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25824

About PRDX5

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,318,121-64,321,811 (from NCBI)

This gene has 3 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in colon (RPKM 157.0), kidney (RPKM 130.3) and 25 other tissues.

Summary

This gene encodes a member of the peroxiredoxin family of antioxidant Enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]

PRDX5 Products (5)

mRNA	Protein	Name
NM_001358511.2	NP_001345440.2	peroxiredoxin-5, mitochondrial isoform d precursor
NM_001358516.2	NP_001345445.1	peroxiredoxin-5, mitochondrial isoform S
NM_012094.5	NP_036226.2	peroxiredoxin-5, mitochondrial isoform L precursor
NM_181651.3	NP_857634.2	peroxiredoxin-5, mitochondrial isoform b precursor
NM_181652.3	NP_857635.2	peroxiredoxin-5, mitochondrial isoform c precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase III transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10095767	GOA
enables antioxidant activity	IDA IDA: Inferred from direct assay	10514471	GOA
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	18262354	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15046979	GOA
enables peroxidase activity	IDA IDA: Inferred from direct assay	10521424	GOA
enables peroxynitrite reductase activity	IDA IDA: Inferred from direct assay	15280035	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10514471	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	10514471	GOA
enables thioredoxin peroxidase activity	EXP EXP: Inferred from Experiment	15280035	GOA
enables thioredoxin peroxidase activity	IDA IDA: Inferred from direct assay	10751410	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in NADPH oxidation	IDA IDA: Inferred from direct assay	10751410	GOA
involved in cellular response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	18262354	GOA
involved in hydrogen peroxide catabolic process	IDA IDA: Inferred from direct assay	10514471	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18262354	GOA
involved in negative regulation of oxidoreductase activity	IDA IDA: Inferred from direct assay	15280035	GOA
involved in negative regulation of transcription by RNA polymerase III	IDA IDA: Inferred from direct assay	10095767	GOA
involved in positive regulation of collagen biosynthetic process	IDA IDA: Inferred from direct assay	15276323	GOA
involved in reactive nitrogen species metabolic process	IDA IDA: Inferred from direct assay	15280035	GOA
involved in regulation of apoptosis involved in tissue homeostasis	IDA IDA: Inferred from direct assay	15276323	GOA
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	10514471	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10514471	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	10095767	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18262354	GOA
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	15785239	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	10521424	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10095767	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10095767	GOA
located in peroxisomal matrix	IDA IDA: Inferred from direct assay	10514471	GOA
located in peroxisome	IDA IDA: Inferred from direct assay	10521424	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDX5 Protein Structure

Redoxin

0
100
200
214 a.a.

Protein Preferred Names	Protein Names
peroxiredoxin-5, mitochondrial	Alu co-repressor 1

PRDX5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRDX5	P30044	NUFIP2	Homo sapiens	Q7Z417	Validated Y2H	32296183
Intra	PRDX5	P30044	NUFIP2	Homo sapiens	Q7Z417	Y2H Array	32296183
Intra	PRDX5	P30044	NUFIP2	Homo sapiens	Q7Z417	Y2H Prey Pooling	32296183
Intra	PRDX5	P30044	CDKN2D	Homo sapiens	P55273	Validated Y2H	32296183
Intra	PRDX5	P30044	SMCP	Homo sapiens	P49901	Validated Y2H	32296183
Intra	PRDX5	P30044	SMCP	Homo sapiens	P49901	Y2H Prey Pooling	32296183
Intra	PRDX5	P30044	SMCP	Homo sapiens	P49901	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRDX5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71146	PRDX5/Peroxiredoxin-5 Protein, Human (HEK293, His)	P30044-1 (M53-L214)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73711	PRDX5/Peroxiredoxin-5 Protein, Human (His)	P30044-1 (M53-L214)	≥ 95%, as determined by reducing SDS-PAGE.

PRDX5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81846	Peroxiredoxin 5 Antibody (YA1591)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P81846A	Peroxiredoxin 5 Antibody (YA1591)(PBS only)	WB, IHC-P, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Fuchs' Endothelial Dystrophy	Fuchs Endothelial Corneal Dystrophy Fuchs Endothelial Dystrophy Fuchs Dystrophy Fced Fuchs' Corneal Dystrophy Fuchs' Endothelial Corneal Dystrophy Fuchs Atrophy Fuchs Corneal Dystrophy Endoepithelial Corneal Dystrophy Fecd Late Hereditary Endothelial Dystrophy Corneal Dystrophy, Fuchs Endothelial Dystrophy, Corneal, Fuchs Endothelial Corneal Dystrophy, Fuchs' Endothelial, 1
Parkinson Disease 7, Autosomal Recessive Early-Onset	Autosomal Recessive Early-Onset Parkinson Disease 7 PARK7 Parkinson'S Disease 7 Autosomal Recessive Early-Onset Parkinson'S Disease 7 Parkinson Disease 7 Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Type 2 Autosomal Recessive Early-Onset Parkinson Disease Type 7 Parkinson Disease, Type 7
Acatalasemia	Acatalasia Catalase Deficiency Deficiency Of Catalase ACATLAS Takahara'S Disease Takahara Disease
Alopecia Areata	Aa Alopecia Celsi Alopecia Circumscripta Cazenave'S Vitiligo Celsus' Vitiligo Diffuse Alopecia Jonston'S Alopecia Marginal Alopecia Pseudopelade Circumscribed Alopecia Alopecia Cicatrisata Patchy Alopecia Alopecia Aa - [Alopecia Areata] Pelade
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1	Vitiligo VAMAS1 Slev1 Vtlg Systemic Lupus Erythematosus, Vitiligo-Related Vitiligo-Associated Multiple Autoimmune Disease 1 Systemic Lupus Erythematosus Vitiligo-Related
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N3225	Myricanol		98.93%	Unkown
HY-RS11078	PRDX5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17470	Prdx6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17919	Prdx5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24388	Prdx5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRDX5	MGD	MGI:1859821
Bos taurus	PRDX5	VGNC	VGNC:33303
Rattus norvegicus	PRDX5	RGD	RGD:71007
Macaca mulatta	PRDX5	VGNC	VGNC:101384
Others	PRDX5	NCBI