Cul3 - cullin 3 Gene

Also Known as KIAA0617

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26554

Summary

Enables cyclin binding activity and identical protein binding activity. Involved in embryonic cleavage; integrin-mediated signaling pathway; and stem cell division. Acts upstream of or within with a positive effect on protein polyubiquitination. Acts upstream of or within several processes, including embryonic morphogenesis; fibroblast apoptotic process; and liver morphogenesis. Located in Golgi apparatus and nucleus. Is expressed in several structures, including extraembryonic component; gonad; heart; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3). [provided by Alliance of Genome Resources, Apr 2022]

Cul3 Products (2)

mRNA Protein Name
NM_001313728.1 NP_001300657.1 cullin-3 isoform 2 precursor
NM_016716.5 NP_057925.1 cullin-3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cyclin binding IPI
IPI: Inferred from physical interaction
10500095 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
22709582 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22709582 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Wnt signaling pathway IDA
IDA: Inferred from direct assay
19056892 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
10500095 MGI
involved in embryonic cleavage IMP
IMP: Inferred from mutant phenotype
22358839 MGI
acts upstream of or within fibroblast apoptotic process IMP
IMP: Inferred from mutant phenotype
17339333 MGI
acts upstream of or within gastrulation IMP
IMP: Inferred from mutant phenotype
10500095 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
25250572 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
10500095 MGI
involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
25250572 MGI
involved in integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
22358839 MGI
acts upstream of or within liver morphogenesis IMP
IMP: Inferred from mutant phenotype
17339333 MGI
acts upstream of or within mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
17339333 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17339333 MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IGI
IGI: Inferred from genetic interaction
20811152 MGI
involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
25250572 MGI
acts upstream of or within positive effect protein polyubiquitination IDA
IDA: Inferred from direct assay
27708159 MGI
involved in protein ubiquitination IMP
IMP: Inferred from mutant phenotype
25250572 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
24863065 MGI
involved in regulation protein catabolic process at postsynapse IDA
IDA: Inferred from direct assay
17062563 MGI
involved in regulation protein catabolic process at postsynapse IEP
IEP: Inferred from expression pattern
17062563 MGI
involved in regulation protein catabolic process at postsynapse IMP
IMP: Inferred from mutant phenotype
17062563 MGI
involved in stem cell division IMP
IMP: Inferred from mutant phenotype
22358839 MGI
acts upstream of or within trophectodermal cellular morphogenesis IMP
IMP: Inferred from mutant phenotype
10500095 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
10500095 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
24863065 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17062563 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
17062563 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17062563 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10500095 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cullin-3

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-159641 VVD-130037 Activator 99.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126075A WS-383 Inhibitor 99.43% Unkown
HY-169766 VVD 065 Degrader 99.71% Unkown
HY-124834 Nrf2 activator-10 98.65% Unkown
HY-RS03361 CUL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-126075 WS-383 free base Inhibitor / Unkown
HY-RS18472 Cul3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24953 Cul3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cul3 NCBI NCBI:8452