Grm4 - glutamate receptor, metabotropic 4 Gene

Also Known as Gprc1d; mGluR4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 268934

About Grm4

Chromosome 17: 27,641,361-27,740,377 reverse strand.GRCm39:CM001010.3

This gene has 8 transcripts (splice variants), 271 orthologues, 7 paralogues and is associated with 4 phenotypes. Biased expression in cerebellum adult (RPKM 6.6), frontal lobe adult (RPKM 7.3) and 3 other tissues.

Summary

Predicted to enable Adenylate Cyclase inhibiting G protein-coupled glutamate receptor activity; calcium-dependent protein binding activity; and Calmodulin binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within chemical synaptic transmission and learning. Located in neuron projection and parallel fiber to Purkinje cell synapse. Is integral component of presynaptic active zone membrane. Is active in glutamatergic synapse. Is expressed in central nervous system; dorsal root ganglion; foot; sensory organ; and skeleton. Orthologous to human GRM4 (glutamate metabotropic receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Grm4 Products (4)

mRNA Protein Name
NM_001013385.2 NP_001013403.1 metabotropic glutamate receptor 4 isoform 2 precursor
NM_001379317.1 NP_001366246.1 metabotropic glutamate receptor 4 isoform 3
NM_001291045.2 NP_001277974.1 metabotropic glutamate receptor 4 isoform 1 precursor
NM_001360192.1 NP_001347121.1 metabotropic glutamate receptor 4 isoform 3

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
8815915 MGI
acts upstream of or within learning IMP
IMP: Inferred from mutant phenotype
8815915 MGI
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
8815915 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
8815915 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
8815915 MGI
Cellular Component GO Annotation Evidence References Source
is active in cerebellar granule cell to Purkinje cell synapse IDA
IDA: Inferred from direct assay
32494600 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
8815915 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
8815915 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
8815915 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
21795692 MGI
is active in parallel fiber to Purkinje cell synapse EXP
EXP: Inferred from Experiment
8815915 MGI
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
8815915 MGI
is active in parallel fiber to Purkinje cell synapse IMP
IMP: Inferred from mutant phenotype
8815915 MGI
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
11906782 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm4 Protein Structure

PBP1_mGluR_groupIII

PBP1_mGluR_groupIII: cd06376 (42 - 507)

NCD3G

NCD3G: pfam07562 (515 - 565)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (585 - 610)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (585 - 911)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (622 - 643)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (652 - 676)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (698 - 718)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (748 - 774)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (782 - 805)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (815 - 840)

  • 0
  • 200
  • 400
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  • 800
  • 912 a.a.
Protein Preferred Names Protein Names

metabotropic glutamate receptor 4

  • G protein-coupled receptor GRM4

  • G protein-coupled receptor, family C, group 1, member D

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15476 VU 0364439 99.42% Unkown
HY-RS05828 GRM4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05829 Grm4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05830 Grm4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grm4 NCBI NCBI:2914