2. Gene
  3. Grm4 - glutamate receptor, metabotropic 4 Gene

Grm4 - glutamate receptor, metabotropic 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Gprc1d; mGluR4

Gene ID: 268934 | Gene type: protein coding

About Grm4

Chromosome 17: 27,641,361-27,740,377 reverse strand.GRCm39:CM001010.3

This gene has 8 transcripts (splice variants), 271 orthologues, 7 paralogues and is associated with 4 phenotypes. Biased expression in cerebellum adult (RPKM 6.6), frontal lobe adult (RPKM 7.3) and 3 other tissues.

Summary

Predicted to enable Adenylate Cyclase inhibiting G protein-coupled glutamate receptor activity; calcium-dependent protein binding activity; and Calmodulin binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within chemical synaptic transmission and learning. Located in neuron projection and parallel fiber to Purkinje cell synapse. Is integral component of presynaptic active zone membrane. Is active in glutamatergic synapse. Is expressed in central nervous system; dorsal root ganglion; foot; sensory organ; and skeleton. Orthologous to human GRM4 (glutamate metabotropic receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Grm4 Products(4)

mRNA Protein Name
NM_001013385.2 NP_001013403.1 metabotropic glutamate receptor 4 isoform 2 precursor
NM_001379317.1 NP_001366246.1 metabotropic glutamate receptor 4 isoform 3
NM_001291045.2 NP_001277974.1 metabotropic glutamate receptor 4 isoform 1 precursor
NM_001360192.1 NP_001347121.1 metabotropic glutamate receptor 4 isoform 3

Grm4 Protein Structure

PBP1_mGluR_groupIII

PBP1_mGluR_groupIII: cd06376 (42 - 507)

NCD3G

NCD3G: pfam07562 (515 - 565)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (585 - 610)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (585 - 911)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (622 - 643)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (652 - 676)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (698 - 718)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (748 - 774)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (782 - 805)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (815 - 840)

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  • 912 a.a.
Protein Preferred Names Protein Names

metabotropic glutamate receptor 4

G protein-coupled receptor GRM4

G protein-coupled receptor, family C, group 1, member D

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05828 GRM4 Human Pre-designed siRNA Set A / Unkown
HY-RS05829 Grm4 Mouse Pre-designed siRNA Set A / Unkown
HY-RS05830 Grm4 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grm4 NCBI NCBI:2914